SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3krv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  48
PRO A 195
THR A  46
 None
 0.91A 1dscC-3krvA:
undetectable		 1dscC-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  46
THR A  48
PRO A 195
 None
 0.77A 1fjaC-3krvA:
undetectable		 1fjaC-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  46
THR A  48
PRO A 195
 None
 0.77A 1fjaD-3krvA:
undetectable		 1fjaD-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  48
PRO A 195
THR A  46
 None
 0.85A 1i3wE-3krvA:
undetectable		 1i3wE-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  46
THR A  48
PRO A 195
 None
 0.84A 1i3wE-3krvA:
undetectable		 1i3wE-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  48
PRO A 195
THR A  46
 None
 0.85A 1i3wG-3krvA:
undetectable		 1i3wG-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  48
PRO A 195
THR A  46
 None
 0.85A 1ovfB-3krvA:
undetectable		 1ovfB-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 166
ILE A  50
ILE A  66
VAL A  72
LEU A  68
 None
None
None
None
CL  A 208 (-4.3A)
 1.01A 1qhyA-3krvA:
undetectable		 1qhyA-3krvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  48
PRO A 195
THR A  46
 None
 0.86A 1unjL-3krvA:
undetectable		 1unjL-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  46
THR A  48
PRO A 195
 None
 0.86A 1unjW-3krvA:
undetectable		 1unjW-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  48
PRO A 195
THR A  46
 None
 0.84A 1unmE-3krvA:
undetectable		 1unmE-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  46
THR A  48
PRO A 195
 None
 0.85A 209dC-3krvA:
undetectable		 209dC-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 130
VAL A 182
MET A 181
ILE A 166
 None
 1.16A 2hyyC-3krvA:
undetectable		 2hyyC-3krvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 158
VAL A 182
MET A 181
ILE A 166
 None
 1.09A 2hyyC-3krvA:
undetectable		 2hyyC-3krvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 196
ALA A 194
THR A 191
MET A  56
VAL A  57
 None
 1.26A 2wuzA-3krvA:
undetectable		 2wuzA-3krvA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 196
ALA A 194
THR A 191
MET A  56
VAL A  57
 None
 1.22A 2wuzB-3krvA:
undetectable		 2wuzB-3krvA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		4 / 7 MET A  42
ALA A 194
ALA A 196
THR A   7
 None
 0.95A 2wx2A-3krvA:
undetectable		 2wx2A-3krvA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		4 / 8 MET A  42
ALA A 194
ALA A 196
THR A   7
 None
 0.98A 2wx2B-3krvA:
undetectable		 2wx2B-3krvA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  48
PRO A 195
THR A  46
 None
 0.85A 316dC-3krvA:
undetectable		 316dC-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 103
PHE A 105
ILE A 135
ALA A 127
THR A 157
 None
 1.16A 3me6C-3krvA:
undetectable		 3me6C-3krvA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 103
PHE A 105
ILE A 135
ALA A 126
VAL A 163
 None
 1.16A 3me6D-3krvA:
undetectable		 3me6D-3krvA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A  91
ILE A 166
ILE A  97
ALA A 126
TYR A 129
 None
 1.05A 3ohtA-3krvA:
undetectable
3ohtB-3krvA:
undetectable		 3ohtA-3krvA:
21.17
3ohtB-3krvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A  48
PRO A 195
THR A  46
 None
 0.88A 4hivD-3krvA:
undetectable		 4hivD-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		6 / 12 ILE A  87
LEU A 104
PHE A 105
ILE A  97
LEU A 130
ILE A  92
 None
 1.24A 4x5iA-3krvA:
undetectable		 4x5iA-3krvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A 135
LEU A 158
PHE A 159
HIS A 155
 None
 1.04A 5vkqB-3krvA:
undetectable
5vkqC-3krvA:
undetectable		 5vkqB-3krvA:
8.35
5vkqC-3krvA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3krv HYDROLASE
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A 135
LEU A 158
PHE A 159
HIS A 155
 None
 1.03A 5vkqC-3krvA:
undetectable
5vkqD-3krvA:
undetectable		 5vkqC-3krvA:
8.35
5vkqD-3krvA:
8.35