SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3krz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 THR A  45
ALA A  47
ILE A  74
THR A  59
LEU A  72
 None
 1.37A 1eiiA-3krzA:
undetectable		 1eiiA-3krzA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 PHE A 195
ILE A 141
VAL A  61
ILE A 162
ILE A 213
 None
 0.93A 1epbA-3krzA:
undetectable		 1epbA-3krzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 PHE A 195
ILE A 141
VAL A  61
ILE A 162
ILE A 213
 None
 0.95A 1epbB-3krzA:
undetectable		 1epbB-3krzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 10 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.89A 1hsgA-3krzA:
undetectable		 1hsgA-3krzA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.83A 1hxbB-3krzA:
undetectable		 1hxbB-3krzA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 9 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.90A 1ohrB-3krzA:
undetectable		 1ohrB-3krzA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 LEU A 296
GLY A 284
ALA A 301
ILE A 295
 None
FMN  A 401 ( 3.7A)
None
None
 0.82A 2aohB-3krzA:
undetectable		 2aohB-3krzA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 7 TYR A  27
TYR A 168
HIS A 166
GLY A 252
 None
TXD  A 402 (-4.6A)
TXD  A 402 ( 3.8A)
TXD  A 402 (-4.0A)
 1.27A 2ha4B-3krzA:
2.5		 2ha4B-3krzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.86A 2o4lB-3krzA:
undetectable		 2o4lB-3krzA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 7 ILE A 278
ILE A 162
LEU A 196
ILE A 200
 None
 0.89A 2q83A-3krzA:
undetectable		 2q83A-3krzA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.92A 2r5pA-3krzA:
undetectable		 2r5pA-3krzA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.92A 2r5pC-3krzA:
undetectable		 2r5pC-3krzA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 6 HIS A 103
GLN A  79
ALA A 144
ALA A 148
 None
 1.05A 2xfhA-3krzA:
undetectable		 2xfhA-3krzA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.87A 3bvbA-3krzA:
undetectable		 3bvbA-3krzA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 10 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.82A 3em3B-3krzA:
undetectable		 3em3B-3krzA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.86A 3em6B-3krzA:
undetectable		 3em6B-3krzA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.88A 3jvyB-3krzA:
undetectable		 3jvyB-3krzA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.85A 3k4vB-3krzA:
undetectable		 3k4vB-3krzA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.90A 3k4vC-3krzA:
undetectable		 3k4vC-3krzA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.90A 3nduC-3krzA:
undetectable		 3nduC-3krzA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.89A 3pwrB-3krzA:
undetectable		 3pwrB-3krzA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 LEU A 169
GLY A 117
PHE A 173
PHE A 195
 None
 1.15A 3smtA-3krzA:
undetectable		 3smtA-3krzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.86A 3tkwB-3krzA:
undetectable		 3tkwB-3krzA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 9 ALA A 102
HIS A 163
HIS A 166
TYR A 168
TYR A  27
 None
FMN  A 401 ( 3.9A)
TXD  A 402 ( 3.8A)
TXD  A 402 (-4.6A)
None
 1.21A 3upwA-3krzA:
36.4		 3upwA-3krzA:
28.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 6 HIS A 163
HIS A 166
TYR A 168
TYR A  27
 FMN  A 401 ( 3.9A)
TXD  A 402 ( 3.8A)
TXD  A 402 (-4.6A)
None
 0.85A 4df2A-3krzA:
36.4		 4df2A-3krzA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.72A 4dqbA-3krzA:
undetectable		 4dqbA-3krzA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.91A 4dqfA-3krzA:
undetectable		 4dqfA-3krzA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 ARG A  64
ILE A 141
HIS A 103
GLY A 105
 None
 1.38A 4e7cC-3krzA:
undetectable		 4e7cC-3krzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 GLU A 113
GLU A  62
GLY A  33
ARG A  66
 None
 1.06A 4fgzA-3krzA:
undetectable
4fgzB-3krzA:
undetectable		 4fgzA-3krzA:
21.81
4fgzB-3krzA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 7 ASP A 221
SER A 178
HIS A 171
SER A 175
 None
 1.02A 4k7gB-3krzA:
undetectable		 4k7gB-3krzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 7 TYR A 235
VAL A 217
ILE A 272
ARG A 275
 None
 0.87A 4lv9A-3krzA:
2.1		 4lv9A-3krzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 SER A  63
GLY A  65
ALA A  60
GLU A 113
TYR A 112
 None
 1.30A 4xt8A-3krzA:
1.7		 4xt8A-3krzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 6 TYR A 112
ARG A  66
GLY A  33
SER A  30
 None
 1.24A 5bphA-3krzA:
undetectable		 5bphA-3krzA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 7 ALA A 123
ASP A 114
ARG A  64
GLY A  65
GLU A  62
 None
 1.10A 5bs8A-3krzA:
undetectable
5bs8C-3krzA:
undetectable
5bs8D-3krzA:
undetectable		 5bs8A-3krzA:
22.49
5bs8C-3krzA:
22.49
5bs8D-3krzA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 6 ALA A 123
ARG A  64
GLY A  65
GLU A  62
 None
 0.86A 5btgA-3krzA:
undetectable
5btgB-3krzA:
undetectable
5btgC-3krzA:
undetectable		 5btgA-3krzA:
22.49
5btgB-3krzA:
21.87
5btgC-3krzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 7 ALA A 123
ASP A 114
ARG A  64
GLY A  65
GLU A  62
 None
 1.19A 5btgA-3krzA:
undetectable
5btgC-3krzA:
undetectable
5btgD-3krzA:
undetectable		 5btgA-3krzA:
22.49
5btgC-3krzA:
22.49
5btgD-3krzA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.88A 5kqyA-3krzA:
undetectable		 5kqyA-3krzA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 9 ALA A  60
THR A  59
ALA A  58
ALA A 102
GLY A  33
 None
None
FMN  A 401 (-3.4A)
None
None
 0.98A 5l5zK-3krzA:
undetectable
5l5zL-3krzA:
undetectable		 5l5zK-3krzA:
22.16
5l5zL-3krzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 9 ALA A  60
THR A  59
ALA A  58
ALA A 102
GLY A  33
 None
None
FMN  A 401 (-3.4A)
None
None
 0.99A 5l5zY-3krzA:
undetectable
5l5zZ-3krzA:
undetectable		 5l5zY-3krzA:
22.16
5l5zZ-3krzA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 5 CYH A  25
ILE A  67
HIS A 163
HIS A 166
TYR A 168
 FMN  A 401 (-3.2A)
None
FMN  A 401 ( 3.9A)
TXD  A 402 ( 3.8A)
TXD  A 402 (-4.6A)
 0.20A 5ocsA-3krzA:
49.6		 5ocsA-3krzA:
39.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 5 CYH A  25
ILE A  67
HIS A 163
HIS A 166
TYR A 168
 FMN  A 401 (-3.2A)
None
FMN  A 401 ( 3.9A)
TXD  A 402 ( 3.8A)
TXD  A 402 (-4.6A)
 0.19A 5ocsC-3krzA:
49.6		 5ocsC-3krzA:
39.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 253
GLY A 105
ALA A 123
GLU A  62
PHE A 145
 None
 1.28A 5x6yA-3krzA:
undetectable		 5x6yA-3krzA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 LEU A 101
VAL A 215
ILE A 239
VAL A 160
ILE A 162
 None
 0.92A 6difB-3krzA:
undetectable		 6difB-3krzA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 ASN A  76
ASP A  71
GLY A  33
ASP A  32
ILE A 110
 None
 1.26A 6dwnA-3krzA:
undetectable		 6dwnA-3krzA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE
(Thermoanaerobact
er
pseudethanolicus) 		3 / 3 TRP A  75
GLU A  62
GLU A 113
 None
 0.96A 6fhwA-3krzA:
undetectable		 6fhwA-3krzA:
14.02