SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ksk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		5 / 11 LEU A  10
TYR A 179
LEU A 204
GLN A 201
HIS A  15
 None
 1.50A 1qabE-3kskA:
undetectable		 1qabE-3kskA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		5 / 11 LEU A 170
TYR A  19
LEU A  44
GLN A  41
HIS A 175
 None
 1.49A 1qabE-3kskA:
undetectable		 1qabE-3kskA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		3 / 3 TYR A 124
ARG A 114
GLN A  65
 None
SO4  A 326 (-4.4A)
None
 0.92A 1tw4A-3kskA:
undetectable		 1tw4A-3kskA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		3 / 3 TYR A 284
ARG A 274
GLN A 225
 None
 0.87A 1tw4A-3kskA:
undetectable		 1tw4A-3kskA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		5 / 11 ILE A  16
TYR A  19
GLY A 197
PHE A 192
ILE A 191
 None
 1.41A 2y7kA-3kskA:
undetectable		 2y7kA-3kskA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		4 / 6 LEU A 169
LEU A 166
SER A 162
THR A  46
 None
None
None
SO4  A 326 (-4.7A)
 1.04A 3cfqA-3kskA:
undetectable		 3cfqA-3kskA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		4 / 8 ASP A 218
GLY A 213
GLN A 256
GLU A 228
 None
 1.03A 3s3mA-3kskA:
undetectable		 3s3mA-3kskA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		4 / 4 PHE A  32
TYR A 264
LEU A  39
LYS A  38
 None
 1.46A 3sudC-3kskA:
0.0		 3sudC-3kskA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		4 / 7 ASN A 233
GLY A 266
GLN A  20
ILE A  31
 None
 0.80A 4fglC-3kskA:
undetectable		 4fglC-3kskA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		3 / 3 ARG A 289
LYS A 290
LYS A 286
 None
 1.11A 4k50A-3kskA:
undetectable		 4k50A-3kskA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		3 / 3 ARG A 129
LYS A 130
LYS A 126
 None
 1.20A 4k50E-3kskA:
undetectable		 4k50E-3kskA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		3 / 3 ARG A 289
LYS A 290
LYS A 286
 None
 1.09A 4k50E-3kskA:
undetectable		 4k50E-3kskA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		3 / 3 ARG A 289
LYS A 290
LYS A 286
 None
 1.04A 4k50I-3kskA:
undetectable		 4k50I-3kskA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3ksk TYPE-2 RESTRICTION
ENZYME PVUII
(Proteus
hauseri) 		3 / 3 GLY A 266
GLN A  17
LYS A 198
 None
 0.91A 5imsB-3kskA:
undetectable		 5imsB-3kskA:
19.12