SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A  73
SER A 122
ASP A 154
ASP A  50
 None
 0.78A 1m4iA-3kstA:
undetectable		 1m4iA-3kstA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A  64
GLY A 276
PHE A 117
PHE A 139
 None
 0.86A 3ko0M-3kstA:
undetectable
3ko0P-3kstA:
undetectable		 3ko0M-3kstA:
15.03
3ko0P-3kstA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A  87
THR A  69
ALA A  91
ALA A  75
 None
 1.23A 3ns1C-3kstA:
undetectable		 3ns1C-3kstA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 233
SER A 230
GLU A 214
 None
 0.53A 3s8pA-3kstA:
undetectable		 3s8pA-3kstA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 288
GLY A 215
ILE A 228
VAL A 241
ALA A 105
 None
CA  A 400 ( 4.8A)
None
None
CA  A 400 ( 4.6A)
 1.14A 4a6dA-3kstA:
undetectable		 4a6dA-3kstA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 PRO A 106
GLY A  67
ALA A  62
GLN A 300
 None
 0.84A 4g0uA-3kstA:
undetectable		 4g0uA-3kstA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 7 HIS A 275
GLY A 215
TYR A 234
SER A 230
 CA  A 400 (-3.7A)
CA  A 400 ( 4.8A)
None
None
 0.93A 4hyfA-3kstA:
undetectable		 4hyfA-3kstA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 121
GLN A  90
TRP A 104
 None
 1.09A 4kn2C-3kstA:
undetectable		 4kn2C-3kstA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 244
TRP A 253
VAL A 254
 None
 0.42A 4w9nC-3kstA:
undetectable		 4w9nC-3kstA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		3 / 5 GLY A  66
GLY A  73
GLU A  72
 None
 0.51A 4z2eA-3kstA:
undetectable
4z2eD-3kstA:
undetectable		 4z2eA-3kstA:
21.46
4z2eD-3kstA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 4 CYH A  76
PHE A  77
ILE A 289
GLY A  64
 None
 1.26A 5hesB-3kstA:
undetectable		 5hesB-3kstA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3kst ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 214
ASP A 154
LEU A  46
ALA A 277
SER A 217
 None
 1.29A 5syeB-3kstA:
undetectable		 5syeB-3kstA:
19.25