SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ksw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 385
PRO A 354
PRO A 355
GLY A 414
GLY A 416
 None
None
None
None
HEM  A 488 ( 4.3A)
 1.15A 2uvnA-3kswA:
21.5		 2uvnA-3kswA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		4 / 8 SER A 296
THR A 295
PRO A 355
THR A 178
 HEM  A 488 ( 4.9A)
VNF  A 490 ( 4.0A)
None
None
 1.10A 2v0zO-3kswA:
undetectable		 2v0zO-3kswA:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 10 MET A 106
PHE A 110
ALA A 287
ALA A 291
THR A 295
VAL A 461
 VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 0.98A 2wuzA-3kswA:
44.9		 2wuzA-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 10 PHE A 110
ALA A 287
ALA A 291
THR A 295
MET A 460
VAL A 461
 None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 0.84A 2wuzA-3kswA:
44.9		 2wuzA-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 10 TYR A 116
ALA A 287
ALA A 291
THR A 295
MET A 460
VAL A 461
 VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 0.85A 2wuzA-3kswA:
44.9		 2wuzA-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 10 MET A 106
PHE A 110
ALA A 287
ALA A 291
THR A 295
VAL A 461
 VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 0.98A 2wuzB-3kswA:
44.7		 2wuzB-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 10 PHE A 110
ALA A 287
ALA A 291
THR A 295
MET A 460
VAL A 461
 None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 0.83A 2wuzB-3kswA:
44.7		 2wuzB-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 10 TYR A 116
ALA A 287
ALA A 291
THR A 295
MET A 460
VAL A 461
 VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 0.83A 2wuzB-3kswA:
44.7		 2wuzB-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 9 MET A 106
PHE A 110
ALA A 287
ALA A 291
THR A 295
LEU A 356
 VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 1.10A 2wv2A-3kswA:
45.9		 2wv2A-3kswA:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 9 PHE A 110
ALA A 291
THR A 295
LEU A 356
MET A 460
 None
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 0.93A 2wv2A-3kswA:
45.9		 2wv2A-3kswA:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 9 PHE A 110
TYR A 116
ALA A 287
ALA A 291
THR A 295
 None
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.57A 2wv2A-3kswA:
45.9		 2wv2A-3kswA:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 9 PHE A 110
TYR A 116
ALA A 291
THR A 295
MET A 460
 None
VNF  A 490 (-4.6A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 0.88A 2wv2A-3kswA:
45.9		 2wv2A-3kswA:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 7 MET A 106
PHE A 110
ALA A 287
ALA A 291
THR A 295
 VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.52A 2wx2A-3kswA:
43.3		 2wx2A-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		4 / 7 MET A 106
PHE A 110
TYR A 116
ALA A 287
 VNF  A 490 ( 3.8A)
None
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
 0.71A 2wx2A-3kswA:
43.3		 2wx2A-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 8 TYR A 103
MET A 106
ALA A 287
ALA A 291
THR A 295
 None
VNF  A 490 ( 3.8A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.72A 2wx2B-3kswA:
41.6		 2wx2B-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 8 TYR A 103
MET A 106
PHE A 110
ALA A 287
ALA A 291
 None
VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
 0.79A 2wx2B-3kswA:
41.6		 2wx2B-3kswA:
97.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 103
MET A 106
ALA A 287
ALA A 291
THR A 295
MET A 360
 None
VNF  A 490 ( 3.8A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 0.75A 2x2nA-3kswA:
39.2		 2x2nA-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 103
MET A 106
PHE A 110
ALA A 212
ALA A 291
THR A 295
 None
VNF  A 490 ( 3.8A)
None
None
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 1.15A 2x2nA-3kswA:
39.2		 2x2nA-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 103
MET A 106
PHE A 110
ALA A 287
ALA A 291
THR A 295
 None
VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 1.06A 2x2nA-3kswA:
39.2		 2x2nA-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 103
MET A 106
TYR A 116
ALA A 212
ALA A 291
 None
VNF  A 490 ( 3.8A)
VNF  A 490 (-4.6A)
None
VNF  A 490 ( 4.0A)
 0.98A 2x2nA-3kswA:
39.2		 2x2nA-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 103
MET A 106
TYR A 116
ALA A 287
ALA A 291
MET A 360
 None
VNF  A 490 ( 3.8A)
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
None
 0.93A 2x2nA-3kswA:
39.2		 2x2nA-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 MET A 106
ALA A 287
ALA A 291
THR A 295
MET A 360
 VNF  A 490 ( 3.8A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 0.76A 2x2nB-3kswA:
45.3		 2x2nB-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 MET A 106
ALA A 291
THR A 295
LEU A 356
MET A 360
 VNF  A 490 ( 3.8A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 0.89A 2x2nB-3kswA:
45.3		 2x2nB-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 MET A 106
PHE A 110
ALA A 287
ALA A 291
THR A 295
 VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 1.14A 2x2nB-3kswA:
45.3		 2x2nB-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 MET A 106
PHE A 110
ALA A 291
THR A 295
LEU A 356
 VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 1.18A 2x2nB-3kswA:
45.3		 2x2nB-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 MET A 106
TYR A 116
ALA A 287
ALA A 291
MET A 360
 VNF  A 490 ( 3.8A)
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
None
 0.94A 2x2nB-3kswA:
45.3		 2x2nB-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 MET A 106
ALA A 287
ALA A 291
THR A 295
MET A 360
 VNF  A 490 ( 3.8A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 0.71A 2x2nC-3kswA:
39.1		 2x2nC-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 MET A 106
ALA A 291
THR A 295
LEU A 356
MET A 360
 VNF  A 490 ( 3.8A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 0.85A 2x2nC-3kswA:
39.1		 2x2nC-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 MET A 106
PHE A 110
VAL A 102
ALA A 287
ALA A 291
THR A 295
 VNF  A 490 ( 3.8A)
None
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 1.40A 2x2nC-3kswA:
39.1		 2x2nC-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 MET A 106
PHE A 110
VAL A 102
ALA A 291
THR A 295
LEU A 356
 VNF  A 490 ( 3.8A)
None
None
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 1.42A 2x2nC-3kswA:
39.1		 2x2nC-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 MET A 106
TYR A 116
ALA A 287
ALA A 291
MET A 360
 VNF  A 490 ( 3.8A)
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
None
 0.94A 2x2nC-3kswA:
39.1		 2x2nC-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 103
MET A 106
ALA A 291
THR A 295
LEU A 356
MET A 360
 None
VNF  A 490 ( 3.8A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 0.77A 2x2nD-3kswA:
39.3		 2x2nD-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 103
MET A 106
PHE A 110
ALA A 287
ALA A 291
THR A 295
 None
VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 1.02A 2x2nD-3kswA:
39.3		 2x2nD-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 103
MET A 106
PHE A 110
ALA A 291
THR A 295
LEU A 356
 None
VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 1.08A 2x2nD-3kswA:
39.3		 2x2nD-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		7 / 12 TYR A 103
MET A 106
TYR A 116
ALA A 287
ALA A 291
THR A 295
MET A 360
 None
VNF  A 490 ( 3.8A)
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 0.88A 2x2nD-3kswA:
39.3		 2x2nD-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 103
PHE A 110
THR A 295
LEU A 356
MET A 460
 None
None
VNF  A 490 ( 4.0A)
None
None
 1.10A 2x2nD-3kswA:
39.3		 2x2nD-3kswA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 103
THR A 295
LEU A 356
MET A 360
MET A 460
 None
VNF  A 490 ( 4.0A)
None
None
None
 0.82A 2x2nD-3kswA:
39.3		 2x2nD-3kswA:
81.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		3 / 3 LEU A 188
VAL A 245
ARG A 247
 None
 0.78A 3b0wB-3kswA:
undetectable		 3b0wB-3kswA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		3 / 3 ALA A 291
THR A 295
CYH A 422
 VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
HEM  A 488 (-2.2A)
 0.74A 3e4eB-3kswA:
26.0		 3e4eB-3kswA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		4 / 4 LEU A  53
PRO A  52
LEU A 385
ARG A 352
 None
 1.44A 3hcoA-3kswA:
undetectable		 3hcoA-3kswA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 8 MET A 106
PHE A 110
ALA A 287
ALA A 291
THR A 295
 VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.61A 3khmA-3kswA:
45.6		 3khmA-3kswA:
98.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 8 MET A 106
PHE A 110
TYR A 116
ALA A 287
ALA A 291
 VNF  A 490 ( 3.8A)
None
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
 0.66A 3khmA-3kswA:
45.6		 3khmA-3kswA:
98.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 8 TYR A 103
MET A 106
ALA A 287
ALA A 291
THR A 295
 None
VNF  A 490 ( 3.8A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.59A 3khmA-3kswA:
45.6		 3khmA-3kswA:
98.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 8 TYR A 103
MET A 106
TYR A 116
ALA A 287
ALA A 291
 None
VNF  A 490 ( 3.8A)
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
 0.77A 3khmA-3kswA:
45.6		 3khmA-3kswA:
98.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		4 / 8 PHE A 110
ALA A 287
ALA A 291
THR A 295
 None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.37A 3l4dA-3kswA:
44.7		 3l4dA-3kswA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		4 / 8 TYR A 103
THR A 295
LEU A 356
MET A 460
 None
VNF  A 490 ( 4.0A)
None
None
 0.74A 3l4dA-3kswA:
44.7		 3l4dA-3kswA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 8 TYR A 103
TYR A 116
ALA A 287
ALA A 291
THR A 295
 None
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.92A 3l4dA-3kswA:
44.7		 3l4dA-3kswA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 9 MET A 106
PHE A 110
TYR A 116
ALA A 287
ALA A 291
THR A 295
 VNF  A 490 ( 3.8A)
None
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.88A 3l4dB-3kswA:
44.7		 3l4dB-3kswA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 9 TYR A 103
MET A 106
TYR A 116
ALA A 291
THR A 295
 None
VNF  A 490 ( 3.8A)
VNF  A 490 (-4.6A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.86A 3l4dB-3kswA:
44.7		 3l4dB-3kswA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 9 TYR A 116
MET A 106
PHE A 110
ALA A 287
ALA A 291
 VNF  A 490 (-4.6A)
VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
 1.30A 3l4dB-3kswA:
44.7		 3l4dB-3kswA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 9 TYR A 103
MET A 106
PHE A 110
THR A 295
LEU A 356
 None
VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 4.0A)
None
 1.00A 3l4dC-3kswA:
44.6		 3l4dC-3kswA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		7 / 9 TYR A 103
MET A 106
PHE A 110
TYR A 116
ALA A 287
ALA A 291
THR A 295
 None
VNF  A 490 ( 3.8A)
None
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.92A 3l4dC-3kswA:
44.6		 3l4dC-3kswA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 8 MET A 106
PHE A 110
ALA A 287
ALA A 291
THR A 295
 VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.63A 3l4dD-3kswA:
44.7		 3l4dD-3kswA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 103
PHE A 110
ALA A 291
THR A 295
MET A 360
 None
None
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 0.81A 3ld6A-3kswA:
27.5		 3ld6A-3kswA:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 103
PHE A 110
ALA A 291
THR A 295
MET A 460
 None
None
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 1.07A 3ld6A-3kswA:
27.5		 3ld6A-3kswA:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 103
PHE A 110
TYR A 116
ALA A 291
MET A 360
 None
None
VNF  A 490 (-4.6A)
VNF  A 490 ( 4.0A)
None
 0.90A 3ld6A-3kswA:
27.5		 3ld6A-3kswA:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 103
PHE A 110
ALA A 291
THR A 295
MET A 360
MET A 460
 None
None
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 1.00A 3ld6B-3kswA:
38.7		 3ld6B-3kswA:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 103
PHE A 110
TYR A 116
ALA A 291
MET A 360
MET A 460
 None
None
VNF  A 490 (-4.6A)
VNF  A 490 ( 4.0A)
None
None
 1.05A 3ld6B-3kswA:
38.7		 3ld6B-3kswA:
36.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		4 / 6 PHE A 184
LEU A 236
ALA A 288
LEU A 262
 None
None
HEM  A 488 ( 4.9A)
None
 0.92A 3t3zA-3kswA:
25.7		 3t3zA-3kswA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		4 / 6 PHE A 184
LEU A 236
ALA A 288
LEU A 262
 None
None
HEM  A 488 ( 4.9A)
None
 0.92A 3t3zB-3kswA:
25.9		 3t3zB-3kswA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		4 / 6 PHE A 184
LEU A 236
ALA A 288
LEU A 262
 None
None
HEM  A 488 ( 4.9A)
None
 0.85A 3t3zD-3kswA:
25.7		 3t3zD-3kswA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		3 / 3 TYR A 103
PHE A  89
ARG A 361
 None
None
HEM  A 488 (-3.3A)
 1.17A 4g19D-3kswA:
undetectable		 4g19D-3kswA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 262
ARG A 247
ILE A 239
ASN A 193
 None
 1.41A 4i00A-3kswA:
undetectable		 4i00A-3kswA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		4 / 9 HIS A 294
PHE A 290
ILE A 105
MET A 106
 None
None
None
VNF  A 490 ( 3.8A)
 1.29A 4jvlA-3kswA:
undetectable		 4jvlA-3kswA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 149
ALA A 179
ALA A 198
ALA A 173
GLY A 172
 None
 1.07A 4oaeA-3kswA:
undetectable		 4oaeA-3kswA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 ASP A 187
LEU A 261
GLY A 263
VAL A 281
LEU A 240
 None
 0.94A 4y8wB-3kswA:
30.2		 4y8wB-3kswA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		3 / 3 VAL A 102
ARG A  88
PRO A  92
 None
 0.85A 5koxA-3kswA:
undetectable		 5koxA-3kswA:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 ALA A 287
ALA A 291
THR A 295
MET A 358
MET A 360
 VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 1.18A 5tl8A-3kswA:
38.1		 5tl8A-3kswA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 PHE A  48
ALA A 291
LEU A 356
MET A 358
MET A 360
 None
VNF  A 490 ( 4.0A)
None
None
None
 1.11A 5tl8A-3kswA:
38.1		 5tl8A-3kswA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 PHE A  48
ALA A 291
THR A 295
MET A 358
MET A 360
 None
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
None
 1.08A 5tl8A-3kswA:
38.1		 5tl8A-3kswA:
36.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		4 / 7 ILE A 285
LEU A 134
PHE A 427
THR A 178
 None
 1.02A 5vc0A-3kswA:
30.7		 5vc0A-3kswA:
26.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 10 TYR A 103
MET A 106
ALA A 287
ALA A 291
LEU A 356
CYH A 422
 None
VNF  A 490 ( 3.8A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
None
HEM  A 488 (-2.2A)
 0.91A 6ay4A-3kswA:
38.5		 6ay4A-3kswA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		8 / 10 TYR A 103
MET A 106
PHE A 110
ALA A 287
PHE A 290
ALA A 291
THR A 295
CYH A 422
 None
VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
None
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
HEM  A 488 (-2.2A)
 0.95A 6ay4A-3kswA:
38.5		 6ay4A-3kswA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 10 TYR A 103
MET A 106
PHE A 110
TYR A 116
CYH A 422
 None
VNF  A 490 ( 3.8A)
None
VNF  A 490 (-4.6A)
HEM  A 488 (-2.2A)
 1.01A 6ay4A-3kswA:
38.5		 6ay4A-3kswA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 9 TYR A 103
ALA A 287
ALA A 291
LEU A 356
CYH A 422
 None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
None
HEM  A 488 (-2.2A)
 0.96A 6ay6A-3kswA:
32.5		 6ay6A-3kswA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 9 TYR A 103
PHE A 110
ALA A 287
ALA A 291
THR A 295
CYH A 422
 None
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
HEM  A 488 (-2.2A)
 0.82A 6ay6A-3kswA:
32.5		 6ay6A-3kswA:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 103
PHE A 110
ALA A 287
ALA A 291
THR A 295
 None
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.84A 6aybA-3kswA:
32.2		 6aybA-3kswA:
36.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 103
MET A 106
ALA A 291
LEU A 356
MET A 360
 None
VNF  A 490 ( 3.8A)
VNF  A 490 ( 4.0A)
None
None
 1.15A 6aycA-3kswA:
38.2		 6aycA-3kswA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 103
MET A 106
ALA A 291
THR A 295
MET A 360
 None
VNF  A 490 ( 3.8A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
None
 1.06A 6aycA-3kswA:
38.2		 6aycA-3kswA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		6 / 12 TYR A 103
MET A 106
PHE A 110
ALA A 287
ALA A 291
THR A 295
 None
VNF  A 490 ( 3.8A)
None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 1.02A 6aycA-3kswA:
38.2		 6aycA-3kswA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		3 / 3 GLU A 348
ASP A 353
PRO A 354
 None
 0.65A 6berA-3kswA:
undetectable		 6berA-3kswA:
1.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		3 / 3 TYR A  35
HIS A  44
PHE A  55
 None
 0.98A 6esmA-3kswA:
undetectable		 6esmA-3kswA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3ksw STEROL 14-ALPHA
DEMETHYLASE
(Trypanosoma
cruzi) 		3 / 3 ILE A 298
THR A 297
PRO A 464
 None
 0.55A 6ncsA-3kswA:
undetectable		 6ncsA-3kswA:
21.83