SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ksy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		4 / 8 SER A1013
ILE A1016
LEU A 886
LEU A1024
 None
 0.63A 1eupA-3ksyA:
undetectable		 1eupA-3ksyA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		5 / 10 VAL A  30
TYR A  47
VAL A  48
ILE A 137
LEU A 142
 None
 1.05A 1fe2A-3ksyA:
undetectable		 1fe2A-3ksyA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		4 / 8 SER A 548
ILE A 137
LYS A 143
VAL A 556
 None
 1.16A 1kb9A-3ksyA:
undetectable
1kb9C-3ksyA:
2.0
1kb9D-3ksyA:
undetectable
1kb9E-3ksyA:
undetectable		 1kb9A-3ksyA:
18.34
1kb9C-3ksyA:
15.71
1kb9D-3ksyA:
13.06
1kb9E-3ksyA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		4 / 7 VAL A 347
TYR A 337
CYH A 391
ARG A 300
 None
 0.98A 1t46A-3ksyA:
undetectable		 1t46A-3ksyA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 LYS A 728
ASP A 293
ASP A 285
 None
 0.98A 2br4D-3ksyA:
undetectable		 2br4D-3ksyA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		5 / 6 LEU A 343
TYR A 298
ILE A 245
ILE A 222
ARG A 227
 None
 1.40A 2q8hA-3ksyA:
4.7		 2q8hA-3ksyA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		4 / 7 LEU A1009
LEU A 833
SER A 876
THR A 828
 None
 0.99A 3lm8A-3ksyA:
undetectable
3lm8C-3ksyA:
undetectable		 3lm8A-3ksyA:
11.73
3lm8C-3ksyA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 PHE A 462
CYH A 471
HIS A 460
 None
 0.90A 3u9fF-3ksyA:
undetectable		 3u9fF-3ksyA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 PHE A 462
CYH A 471
HIS A 460
 None
 0.90A 3u9fG-3ksyA:
undetectable		 3u9fG-3ksyA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 PHE A 462
CYH A 471
HIS A 460
 None
 0.86A 3u9fL-3ksyA:
undetectable		 3u9fL-3ksyA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 PHE A 462
CYH A 471
HIS A 460
 None
 0.96A 3u9fS-3ksyA:
undetectable		 3u9fS-3ksyA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 LEU A  38
GLU A 156
SER A  40
 None
 0.83A 4ccqA-3ksyA:
undetectable		 4ccqA-3ksyA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		4 / 8 ASP A 369
VAL A 205
HIS A 276
TYR A 201
 None
 1.09A 4f5zA-3ksyA:
undetectable		 4f5zA-3ksyA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		4 / 8 SER A 256
LEU A 259
PHE A 208
TYR A 215
 None
 1.22A 4j7uD-3ksyA:
undetectable		 4j7uD-3ksyA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		4 / 7 PRO A 768
SER A 766
VAL A 761
TRP A 763
 None
 1.49A 4kmmA-3ksyA:
undetectable		 4kmmA-3ksyA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 ASP A 241
ASN A 233
SER A 313
 None
 0.86A 4obwA-3ksyA:
undetectable		 4obwA-3ksyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		4 / 8 GLU A 272
ASP A 271
ARG A 694
PRO A 621
 None
 1.15A 4uhxA-3ksyA:
undetectable		 4uhxA-3ksyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		4 / 8 GLU A 272
ASP A 271
ARG A 694
PRO A 621
 None
 1.15A 4uhxA-3ksyA:
undetectable		 4uhxA-3ksyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		4 / 8 GLN A 975
LEU A 821
LEU A 804
THR A 629
 None
 1.05A 5hs6A-3ksyA:
undetectable		 5hs6A-3ksyA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 ARG A 706
HIS A 700
ARG A 632
 None
 0.94A 5iaoC-3ksyA:
undetectable		 5iaoC-3ksyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 ARG A 706
HIS A 700
ARG A 632
 None
 0.94A 5iaoF-3ksyA:
undetectable		 5iaoF-3ksyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		5 / 12 PHE A 588
LEU A 640
ARG A 688
ILE A 610
TYR A 618
 None
 1.26A 5ifuA-3ksyA:
undetectable		 5ifuA-3ksyA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		5 / 9 LEU A 788
HIS A 827
ILE A 855
GLU A 857
VAL A 861
 None
 0.88A 5igzA-3ksyA:
2.1		 5igzA-3ksyA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 GLY A 438
CYH A 441
CYH A 440
 None
 0.94A 5inzB-3ksyA:
undetectable		 5inzB-3ksyA:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 ARG A 706
PRO A 819
ASN A 820
 None
 1.00A 5jwaA-3ksyA:
undetectable
5jwaH-3ksyA:
undetectable		 5jwaA-3ksyA:
19.26
5jwaH-3ksyA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		3 / 3 LYS A 534
GLN A 500
ASN A 502
 None
 0.96A 5l2tA-3ksyA:
undetectable		 5l2tA-3ksyA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		5 / 12 PHE A 331
THR A 549
PHE A 230
ALA A 321
GLU A 333
 None
 1.15A 5vcgA-3ksyA:
undetectable		 5vcgA-3ksyA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens) 		4 / 7 HIS A 780
PRO A 781
ILE A 782
SER A 853
 None
 0.80A 5vkqA-3ksyA:
2.9
5vkqD-3ksyA:
2.9		 5vkqA-3ksyA:
19.39
5vkqD-3ksyA:
19.39