SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ktn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 12 VAL A 195
LEU A 189
TYR A 185
GLY A 197
PHE A 236
 None
 1.39A 1fdsA-3ktnA:
8.2		 1fdsA-3ktnA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 12 VAL A 320
GLY A 287
ILE A 284
THR A 318
VAL A 323
 None
 0.99A 1k6cB-3ktnA:
undetectable		 1k6cB-3ktnA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		3 / 3 ASN A  37
ALA A 282
ASN A 304
 None
 0.81A 1n4fA-3ktnA:
undetectable		 1n4fA-3ktnA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 12 PHE A 236
LEU A 189
PHE A 166
VAL A 195
VAL A 203
 None
 1.10A 1q23H-3ktnA:
undetectable
1q23I-3ktnA:
undetectable		 1q23H-3ktnA:
20.22
1q23I-3ktnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 12 LEU A 140
ILE A 136
CYH A 134
GLY A  35
SER A 109
 None
SO4  A 401 ( 4.4A)
None
None
None
 1.21A 2bxeB-3ktnA:
undetectable		 2bxeB-3ktnA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		4 / 7 LEU A  27
PRO A  15
GLY A 313
ASP A 314
 None
 0.84A 2ddwB-3ktnA:
19.1		 2ddwB-3ktnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 9 ALA A 301
LEU A 254
ILE A 194
PHE A 196
THR A 302
 None
 1.30A 3fl9H-3ktnA:
undetectable		 3fl9H-3ktnA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 9 ALA A 301
LEU A 254
ILE A 194
PHE A 196
THR A 302
 None
 1.29A 3freX-3ktnA:
undetectable		 3freX-3ktnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 11 ALA A 301
LEU A 254
ILE A 194
PHE A 196
THR A 302
 None
 1.23A 3jw5A-3ktnA:
undetectable		 3jw5A-3ktnA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		4 / 7 SER A 137
LEU A 205
ARG A 145
ILE A 188
 None
 1.07A 3ln1C-3ktnA:
undetectable		 3ln1C-3ktnA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 9 HIS A 132
LEU A  38
LEU A  42
LEU A  -1
SER A 289
 None
 1.49A 3q1eB-3ktnA:
undetectable
3q1eD-3ktnA:
undetectable		 3q1eB-3ktnA:
16.42
3q1eD-3ktnA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		6 / 12 LEU A 307
VAL A 320
GLY A 287
ILE A 284
THR A 318
VAL A 323
 None
 1.34A 3so9B-3ktnA:
undetectable		 3so9B-3ktnA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 12 TYR A 185
GLY A 197
LEU A 205
ALA A 281
PHE A 164
 None
 1.09A 3vywA-3ktnA:
undetectable		 3vywA-3ktnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 12 TYR A 185
GLY A 197
LEU A 205
ALA A 281
PHE A 164
 None
 1.10A 3vywB-3ktnA:
2.6		 3vywB-3ktnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 12 TYR A 185
GLY A 197
LEU A 205
ALA A 281
PHE A 164
 None
 1.05A 3vywC-3ktnA:
undetectable		 3vywC-3ktnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 12 TYR A 185
GLY A 197
LEU A 205
ALA A 281
PHE A 164
 None
 1.04A 3vywD-3ktnA:
undetectable		 3vywD-3ktnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		4 / 8 VAL A  32
ASN A  30
GLN A 312
ILE A 274
 None
 1.03A 4iilA-3ktnA:
3.8		 4iilA-3ktnA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		4 / 4 PHE A 164
HIS A 132
GLY A 135
ILE A 133
 None
 1.23A 4k50E-3ktnA:
undetectable		 4k50E-3ktnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		4 / 4 PHE A 164
HIS A 132
GLY A 135
ILE A 133
 None
 1.22A 4k50M-3ktnA:
undetectable		 4k50M-3ktnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 12 HIS A 309
LEU A 307
GLY A  33
THR A 318
THR A  34
 None
 1.44A 4mubA-3ktnA:
1.1		 4mubA-3ktnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3ktn CARBOHYDRATE KINASE,
PFKB FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A  33
GLY A  35
ILE A 315
ILE A 136
LEU A  55
 None
None
None
SO4  A 401 ( 4.4A)
None
 1.08A 5fa8A-3ktnA:
3.5		 5fa8A-3ktnA:
17.66