SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3kts GLYCEROL UPTAKE
OPERON
ANTITERMINATOR
REGULATORY PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 152
GLY A 154
SER A 177
HIS A  15
LEU A  61
 None
UNL  A 191 ( 3.7A)
UNL  A 191 ( 2.8A)
None
None
 1.42A 1fm6X-3ktsA:
undetectable		 1fm6X-3ktsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3kts GLYCEROL UPTAKE
OPERON
ANTITERMINATOR
REGULATORY PROTEIN
(Listeria
monocytogenes) 		5 / 10 GLU A 130
GLY A 134
GLY A 155
ILE A 129
LEU A 106
 UNL  A 191 ( 4.9A)
None
UNL  A 191 ( 3.4A)
None
None
 1.16A 1x7pA-3ktsA:
undetectable
1x7pB-3ktsA:
undetectable		 1x7pA-3ktsA:
20.34
1x7pB-3ktsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 3kts GLYCEROL UPTAKE
OPERON
ANTITERMINATOR
REGULATORY PROTEIN
(Listeria
monocytogenes) 		4 / 5 LEU A  75
ILE A  84
SER A  86
ARG A 105
 None
None
None
UNL  A 191 ( 4.3A)
 0.93A 2byoA-3ktsA:
undetectable		 2byoA-3ktsA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUG_A_HLTA149_1
(CALMODULIN)		 3kts GLYCEROL UPTAKE
OPERON
ANTITERMINATOR
REGULATORY PROTEIN
(Listeria
monocytogenes) 		4 / 5 MET A  33
LEU A  57
MET A  20
LYS A  46
 None
 1.44A 2kugA-3ktsA:
undetectable		 2kugA-3ktsA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 3kts GLYCEROL UPTAKE
OPERON
ANTITERMINATOR
REGULATORY PROTEIN
(Listeria
monocytogenes) 		5 / 10 LEU A  28
ALA A 173
GLY A 154
ILE A 157
ILE A  11
 None
None
UNL  A 191 ( 3.7A)
UNL  A 191 ( 4.8A)
None
 1.08A 4njuB-3ktsA:
undetectable		 4njuB-3ktsA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 3kts GLYCEROL UPTAKE
OPERON
ANTITERMINATOR
REGULATORY PROTEIN
(Listeria
monocytogenes) 		5 / 10 LEU A  28
ALA A 173
GLY A 154
ILE A 157
ILE A  11
 None
None
UNL  A 191 ( 3.7A)
UNL  A 191 ( 4.8A)
None
 1.08A 4njuD-3ktsA:
undetectable		 4njuD-3ktsA:
18.68