SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kul'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 685
GLU A 629
ILE A 630
ARG A 634
LEU A 654
 None
 1.26A 1d1gA-3kulA:
undetectable		 1d1gA-3kulA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		3 / 3 MET A 748
LEU A 751
SER A 752
 None
 0.42A 1ee2A-3kulA:
undetectable		 1ee2A-3kulA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.65A 1iepA-3kulA:
31.9		 1iepA-3kulA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
 None
None
None
None
None
GOL  A 403 (-3.4A)
 0.68A 1iepB-3kulA:
31.8		 1iepB-3kulA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
LYS A 667
GLU A 684
THR A 713
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.67A 1m17A-3kulA:
30.5		 1m17A-3kulA:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
 None
None
None
None
None
GOL  A 403 (-3.4A)
 0.71A 1opjB-3kulA:
31.5		 1opjB-3kulA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
GLU A 684
THR A 713
LEU A 751
HIS A 758
 None
 0.55A 1uwhA-3kulA:
19.6		 1uwhA-3kulA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 ALA A 665
LYS A 667
GLU A 684
THR A 713
LEU A 751
HIS A 758
 None
 0.60A 1uwhB-3kulA:
19.4		 1uwhB-3kulA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
GLU A 684
THR A 713
LEU A 751
HIS A 758
 None
 0.58A 1uwjA-3kulA:
7.9		 1uwjA-3kulA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
GLU A 684
THR A 713
LEU A 751
HIS A 758
 None
 0.58A 1uwjB-3kulA:
7.9		 1uwjB-3kulA:
29.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 ALA A 665
THR A 713
GLY A 719
ARG A 726
LEU A 767
ASP A 778
 None
None
GOL  A 403 (-3.4A)
None
None
None
 0.81A 1xkkA-3kulA:
31.1		 1xkkA-3kulA:
34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
MET A 688
ILE A 711
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.62A 2gqgB-3kulA:
35.6		 2gqgB-3kulA:
34.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		4 / 6 SER A 752
ASP A 753
SER A 817
VAL A 821
 None
SO4  A 910 ( 4.1A)
None
None
 1.26A 2hdnI-3kulA:
undetectable
2hdnJ-3kulA:
undetectable
2hdnL-3kulA:
undetectable		 2hdnI-3kulA:
9.00
2hdnJ-3kulA:
23.51
2hdnL-3kulA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		4 / 6 SER A 817
VAL A 821
SER A 752
ASP A 753
 None
None
None
SO4  A 910 ( 4.1A)
 1.25A 2hdnJ-3kulA:
undetectable
2hdnK-3kulA:
undetectable
2hdnL-3kulA:
undetectable		 2hdnJ-3kulA:
23.51
2hdnK-3kulA:
9.00
2hdnL-3kulA:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.66A 2hyyA-3kulA:
32.0		 2hyyA-3kulA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.64A 2hyyB-3kulA:
32.2		 2hyyB-3kulA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
LEU A 767
 None
 0.65A 2hyyD-3kulA:
26.4		 2hyyD-3kulA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
LYS A 667
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.80A 2itoA-3kulA:
34.1		 2itoA-3kulA:
32.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		9 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.87A 2ityA-3kulA:
34.1		 2ityA-3kulA:
32.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		9 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.81A 2itzA-3kulA:
34.0		 2itzA-3kulA:
32.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		3 / 3 ALA A 665
GLY A 719
SER A 777
 None
GOL  A 403 (-3.4A)
None
 0.53A 2ivuA-3kulA:
35.6		 2ivuA-3kulA:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		9 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.65A 2oiqA-3kulA:
33.2		 2oiqA-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		9 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
 None
None
None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
 0.76A 2oiqA-3kulA:
33.2		 2oiqA-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
LEU A 767
 None
 0.64A 2pl0A-3kulA:
31.8		 2pl0A-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
 None
 0.66A 2pl0A-3kulA:
31.8		 2pl0A-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
LYS A 667
MET A 688
ILE A 711
THR A 713
TYR A 715
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
 0.61A 2pl0A-3kulA:
31.8		 2pl0A-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
MET A 688
ILE A 711
THR A 713
TYR A 715
LEU A 767
 None
None
None
None
None
GOL  A 403 (-4.1A)
None
 0.81A 2pl0A-3kulA:
31.8		 2pl0A-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 9 VAL A 649
ALA A 665
MET A 716
GLY A 719
LEU A 767
ASP A 778
 None
None
None
GOL  A 403 (-3.4A)
None
None
 0.69A 2xp2A-3kulA:
33.1		 2xp2A-3kulA:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		9 / 12 ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.69A 2y6oA-3kulA:
36.5		 2y6oA-3kulA:
68.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		9 / 12 ALA A 665
LYS A 667
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.60A 2y6oA-3kulA:
36.5		 2y6oA-3kulA:
68.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		9 / 12 LYS A 639
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
 1.08A 2y6oA-3kulA:
36.5		 2y6oA-3kulA:
68.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		9 / 12 LYS A 639
ALA A 665
LYS A 667
MET A 688
ILE A 711
THR A 713
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 1.03A 2y6oA-3kulA:
36.5		 2y6oA-3kulA:
68.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
ILE A 697
MET A 716
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.92A 2y7jA-3kulA:
26.9		 2y7jA-3kulA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 10 VAL A 649
ALA A 665
ILE A 697
MET A 716
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.93A 2y7jB-3kulA:
27.4		 2y7jB-3kulA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 10 VAL A 649
ALA A 665
ILE A 697
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-3.4A)
None
 0.76A 2y7jC-3kulA:
26.9		 2y7jC-3kulA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 10 VAL A 649
ALA A 665
ILE A 697
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-3.4A)
None
 0.72A 2y7jD-3kulA:
27.2		 2y7jD-3kulA:
26.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
LYS A 667
MET A 688
ILE A 711
THR A 713
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.61A 2zvaA-3kulA:
34.7		 2zvaA-3kulA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
THR A 713
GLY A 719
LEU A 767
ASP A 778
PHE A 779
 None
None
None
GOL  A 403 (-3.4A)
None
None
None
 0.99A 3bbtB-3kulA:
30.6		 3bbtB-3kulA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
THR A 713
GLY A 719
LEU A 767
ASP A 778
PHE A 779
 None
None
None
GOL  A 403 (-3.4A)
None
None
None
 0.96A 3bbtD-3kulA:
30.8		 3bbtD-3kulA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
HIS A 758
LEU A 767
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.60A 3cs9A-3kulA:
32.1		 3cs9A-3kulA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
HIS A 758
 None
None
None
None
GOL  A 403 (-3.4A)
None
 0.67A 3cs9B-3kulA:
32.4		 3cs9B-3kulA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
GLU A 684
MET A 688
THR A 713
HIS A 758
 None
 0.59A 3cs9C-3kulA:
26.9		 3cs9C-3kulA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
MET A 688
THR A 713
GLY A 719
HIS A 758
 None
None
None
GOL  A 403 (-3.4A)
None
 0.44A 3cs9D-3kulA:
31.1		 3cs9D-3kulA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.53A 3g5dA-3kulA:
34.2		 3g5dA-3kulA:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
LYS A 667
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.81A 3g5dB-3kulA:
34.3		 3g5dB-3kulA:
38.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
GLU A 684
ILE A 697
THR A 713
HIS A 758
 None
 0.74A 3gp0A-3kulA:
22.2		 3gp0A-3kulA:
27.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
LEU A 767
 None
 0.60A 3gvuA-3kulA:
32.6		 3gvuA-3kulA:
38.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 697
THR A 713
 None
 0.75A 3hegA-3kulA:
21.2		 3hegA-3kulA:
25.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
GLU A 684
MET A 688
HIS A 758
LEU A 767
 None
 0.53A 3ik3A-3kulA:
32.0		 3ik3A-3kulA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
GLU A 684
MET A 688
HIS A 758
LEU A 767
 None
 0.54A 3ik3B-3kulA:
25.8		 3ik3B-3kulA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
SER A 777
 None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.66A 3k54A-3kulA:
32.5		 3k54A-3kulA:
36.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
LYS A 667
GLU A 684
ILE A 711
THR A 713
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.87A 3k54A-3kulA:
32.5		 3k54A-3kulA:
36.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
LYS A 667
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.83A 3k54A-3kulA:
32.5		 3k54A-3kulA:
36.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
SER A 777
 None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.53A 3k54A-3kulA:
32.5		 3k54A-3kulA:
36.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.68A 3k5vA-3kulA:
31.5		 3k5vA-3kulA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.66A 3k5vB-3kulA:
31.2		 3k5vB-3kulA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 8 ALA A 665
LYS A 667
GLU A 684
THR A 713
MET A 716
 None
 0.52A 3lfaA-3kulA:
21.1		 3lfaA-3kulA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		4 / 5 LEU A 751
ARG A 884
ILE A 888
PHE A 885
 None
SO4  A 910 (-4.6A)
None
None
 1.21A 3ln1D-3kulA:
undetectable		 3ln1D-3kulA:
17.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 11 ALA A 665
MET A 716
GLY A 719
LEU A 767
SER A 777
ASP A 778
 None
None
GOL  A 403 (-3.4A)
None
None
None
 0.77A 3miyA-3kulA:
33.9		 3miyA-3kulA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 9 ALA A 665
MET A 716
GLY A 719
LEU A 767
SER A 777
 None
None
GOL  A 403 (-3.4A)
None
None
 0.59A 3miyB-3kulA:
28.6		 3miyB-3kulA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
LEU A 767
 None
 0.62A 3ms9A-3kulA:
26.4		 3ms9A-3kulA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.66A 3ms9B-3kulA:
31.7		 3ms9B-3kulA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
LEU A 767
 None
 0.63A 3mssA-3kulA:
31.6		 3mssA-3kulA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.68A 3mssB-3kulA:
31.8		 3mssB-3kulA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
LEU A 767
 None
 0.64A 3mssC-3kulA:
31.6		 3mssC-3kulA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-3.4A)
None
 0.56A 3mssD-3kulA:
31.7		 3mssD-3kulA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
LYS A 667
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.66A 3octA-3kulA:
32.8		 3octA-3kulA:
40.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.48A 3oezA-3kulA:
33.3		 3oezA-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.55A 3oezA-3kulA:
33.3		 3oezA-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
TYR A 715
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
 0.54A 3oezB-3kulA:
33.0		 3oezB-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
ILE A 711
THR A 713
TYR A 715
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
 0.74A 3oezB-3kulA:
33.0		 3oezB-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 VAL A 649
ALA A 665
LYS A 667
THR A 713
PHE A 779
 None
 0.79A 3og7A-3kulA:
28.5		 3og7A-3kulA:
32.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 697
THR A 713
GLY A 719
 None
None
None
None
None
GOL  A 403 (-3.4A)
 0.89A 3ohtB-3kulA:
17.0		 3ohtB-3kulA:
26.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
HIS A 758
 None
None
None
None
GOL  A 403 (-3.4A)
None
 0.61A 3oxzA-3kulA:
31.7		 3oxzA-3kulA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-3.4A)
None
 0.57A 3pyyA-3kulA:
32.2		 3pyyA-3kulA:
37.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-3.4A)
None
 0.69A 3pyyA-3kulA:
32.2		 3pyyA-3kulA:
37.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
LEU A 767
 None
 0.63A 3pyyB-3kulA:
31.6		 3pyyB-3kulA:
37.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
LYS A 667
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.81A 3qlgA-3kulA:
27.5		 3qlgA-3kulA:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		4 / 7 LEU A 761
VAL A 827
VAL A 776
LEU A 832
 None
 0.86A 3rgfA-3kulA:
8.1		 3rgfA-3kulA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.64A 3sxrA-3kulA:
33.8		 3sxrA-3kulA:
35.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.59A 3sxrA-3kulA:
33.8		 3sxrA-3kulA:
35.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.58A 3sxrB-3kulA:
33.7		 3sxrB-3kulA:
35.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
MET A 688
THR A 713
TYR A 715
GLY A 719
SER A 777
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.74A 3sxrB-3kulA:
33.7		 3sxrB-3kulA:
35.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
LYS A 667
GLU A 684
ILE A 711
THR A 713
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.57A 3ue4A-3kulA:
35.5		 3ue4A-3kulA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.58A 3ue4B-3kulA:
35.9		 3ue4B-3kulA:
34.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		4 / 8 VAL A 649
LYS A 667
ILE A 697
ASP A 778
 None
 0.47A 3warA-3kulA:
23.2		 3warA-3kulA:
24.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 ALA A 665
MET A 716
GLY A 719
THR A 723
LEU A 767
ASP A 778
 None
None
GOL  A 403 (-3.4A)
None
None
None
 0.58A 3zbfA-3kulA:
35.0		 3zbfA-3kulA:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
LYS A 667
GLU A 684
THR A 713
LEU A 751
HIS A 758
ARG A 759
LEU A 767
 None
 1.08A 3zosA-3kulA:
24.4		 3zosA-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 9 ILE A 687
MET A 688
ILE A 696
ILE A 697
TYR A 715
MET A 716
 None
None
None
None
GOL  A 403 (-4.1A)
None
 0.83A 3zosA-3kulA:
24.4		 3zosA-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
LYS A 667
GLU A 684
ILE A 697
THR A 713
HIS A 758
ARG A 759
LEU A 767
 None
 1.03A 3zosB-3kulA:
24.5		 3zosB-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
LYS A 667
GLU A 684
ILE A 697
THR A 713
LEU A 751
HIS A 758
LEU A 767
 None
 0.52A 3zosB-3kulA:
24.5		 3zosB-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 9 ILE A 687
MET A 688
ILE A 696
TYR A 715
MET A 716
 None
None
None
GOL  A 403 (-4.1A)
None
 0.89A 3zosB-3kulA:
24.5		 3zosB-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 9 VAL A 649
ALA A 665
MET A 716
GLY A 719
LEU A 767
ASP A 778
 None
None
None
GOL  A 403 (-3.4A)
None
None
 0.71A 4anqA-3kulA:
32.6		 4anqA-3kulA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
GLU A 684
ILE A 687
MET A 688
ILE A 697
THR A 713
TYR A 715
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
 1.06A 4bkjA-3kulA:
27.0		 4bkjA-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 697
THR A 713
TYR A 715
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
 0.99A 4bkjA-3kulA:
27.0		 4bkjA-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
GLU A 684
ILE A 687
MET A 688
ILE A 697
THR A 713
LEU A 767
 None
 0.76A 4bkjB-3kulA:
27.1		 4bkjB-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 697
THR A 713
LEU A 767
 None
 0.81A 4bkjB-3kulA:
27.1		 4bkjB-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
LYS A 667
GLU A 684
ILE A 711
THR A 713
HIS A 758
LEU A 767
 None
 0.49A 4c8bA-3kulA:
27.6		 4c8bA-3kulA:
31.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		4 / 5 VAL A 649
ILE A 696
TYR A 715
MET A 716
 None
None
GOL  A 403 (-4.1A)
None
 0.63A 4c8bA-3kulA:
27.6		 4c8bA-3kulA:
31.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
LYS A 667
GLU A 684
ILE A 696
THR A 713
HIS A 758
LEU A 767
 None
 0.56A 4c8bB-3kulA:
27.2		 4c8bB-3kulA:
31.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		3 / 3 TYR A 715
MET A 716
ILE A 696
 GOL  A 403 (-4.1A)
None
None
 0.67A 4c8bB-3kulA:
27.2		 4c8bB-3kulA:
31.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
GLU A 684
ILE A 687
MET A 688
THR A 713
TYR A 715
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
 0.74A 4csvA-3kulA:
33.5		 4csvA-3kulA:
40.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
LYS A 667
THR A 713
MET A 716
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.96A 4hjoA-3kulA:
31.3		 4hjoA-3kulA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
THR A 713
MET A 716
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.62A 4hjoA-3kulA:
31.3		 4hjoA-3kulA:
33.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 SER A 823
LEU A 761
PHE A 885
ASP A 753
GLY A 755
 None
None
None
SO4  A 910 ( 4.1A)
None
 1.50A 4j7xA-3kulA:
undetectable		 4j7xA-3kulA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_2
(SERUM ALBUMIN)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		4 / 4 VAL A 702
GLU A 684
ASP A 692
LYS A 775
 None
 1.42A 4l9qA-3kulA:
1.6		 4l9qA-3kulA:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
TYR A 715
GLY A 719
ASP A 778
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.84A 4mxoA-3kulA:
35.1		 4mxoA-3kulA:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
ASP A 778
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.74A 4mxoA-3kulA:
35.1		 4mxoA-3kulA:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.77A 4mxoB-3kulA:
29.0		 4mxoB-3kulA:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.75A 4mxoB-3kulA:
29.0		 4mxoB-3kulA:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
GLU A 684
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.80A 4mxxA-3kulA:
28.8		 4mxxA-3kulA:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
LYS A 667
GLU A 684
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.94A 4mxxA-3kulA:
28.8		 4mxxA-3kulA:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
THR A 713
TYR A 715
MET A 716
GLY A 719
LEU A 767
 None
None
None
GOL  A 403 (-4.1A)
None
GOL  A 403 (-3.4A)
None
 0.54A 4mxxB-3kulA:
33.3		 4mxxB-3kulA:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 711
TYR A 715
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.80A 4mxyA-3kulA:
34.9		 4mxyA-3kulA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 711
TYR A 715
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.80A 4mxzA-3kulA:
34.9		 4mxzA-3kulA:
38.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 8 VAL A 649
ALA A 665
ASN A 765
LEU A 767
ASP A 778
 None
 0.54A 4ogrA-3kulA:
25.5		 4ogrA-3kulA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 ALA A 665
GLU A 684
ILE A 711
TYR A 715
LEU A 767
ASP A 778
 None
None
None
GOL  A 403 (-4.1A)
None
None
 0.76A 4qmnA-3kulA:
29.0		 4qmnA-3kulA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 11 ALA A 665
LYS A 667
GLU A 684
ILE A 711
TYR A 715
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-4.1A)
None
None
 0.91A 4qmsA-3kulA:
28.9		 4qmsA-3kulA:
28.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
GLU A 684
MET A 688
LEU A 751
ARG A 759
 None
 0.96A 4qrcA-3kulA:
32.7		 4qrcA-3kulA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
THR A 713
LEU A 767
 None
 0.74A 4r7iA-3kulA:
32.3		 4r7iA-3kulA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
LYS A 667
ILE A 711
THR A 713
PHE A 779
 None
 0.71A 4rzvA-3kulA:
7.8		 4rzvA-3kulA:
33.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
LYS A 667
ILE A 711
THR A 713
SER A 720
 None
 0.49A 4rzvA-3kulA:
7.8		 4rzvA-3kulA:
33.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 VAL A 649
ALA A 665
LYS A 667
THR A 713
PHE A 779
 None
 0.83A 4rzvB-3kulA:
24.2		 4rzvB-3kulA:
33.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 VAL A 649
ALA A 665
LYS A 667
THR A 713
SER A 720
 None
 0.78A 4rzvB-3kulA:
24.2		 4rzvB-3kulA:
33.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
LYS A 667
MET A 716
GLY A 719
ASN A 765
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
None
 0.62A 4twpA-3kulA:
35.4		 4twpA-3kulA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
GLU A 684
MET A 688
HIS A 758
LEU A 767
 None
 0.56A 4tyjA-3kulA:
32.8		 4tyjA-3kulA:
34.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 ALA A 665
LYS A 667
THR A 713
GLY A 719
HIS A 758
LEU A 767
 None
None
None
GOL  A 403 (-3.4A)
None
None
 0.32A 4u0iA-3kulA:
32.6		 4u0iA-3kulA:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 11 VAL A 649
ALA A 665
TYR A 715
MET A 716
GLY A 719
ASN A 765
LEU A 767
ASP A 778
 None
None
GOL  A 403 (-4.1A)
None
GOL  A 403 (-3.4A)
None
None
None
 0.68A 4u5jA-3kulA:
28.9		 4u5jA-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 9 VAL A 649
ALA A 665
TYR A 715
MET A 716
GLY A 719
LEU A 767
 None
None
GOL  A 403 (-4.1A)
None
GOL  A 403 (-3.4A)
None
 0.51A 4u5jB-3kulA:
34.5		 4u5jB-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
GLU A 684
MET A 688
LEU A 751
HIS A 758
 None
 0.62A 4v01A-3kulA:
26.5		 4v01A-3kulA:
34.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
GLU A 684
MET A 688
LEU A 751
HIS A 758
 None
 0.57A 4v01B-3kulA:
10.4		 4v01B-3kulA:
34.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 8 MET A 688
ILE A 697
TYR A 715
ARG A 759
LEU A 767
 None
None
GOL  A 403 (-4.1A)
None
None
 1.48A 4v04A-3kulA:
32.1		 4v04A-3kulA:
34.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 11 ALA A 665
THR A 713
MET A 716
GLY A 719
ASN A 765
LEU A 767
 None
None
None
GOL  A 403 (-3.4A)
None
None
 0.38A 4wa9A-3kulA:
31.0		 4wa9A-3kulA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
LYS A 667
THR A 713
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.69A 4wa9B-3kulA:
34.8		 4wa9B-3kulA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
THR A 713
MET A 716
GLY A 719
ASN A 765
LEU A 767
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.63A 4wa9B-3kulA:
34.8		 4wa9B-3kulA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
LYS A 667
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.64A 4wkqA-3kulA:
34.6		 4wkqA-3kulA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
LYS A 667
MET A 688
ILE A 711
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.68A 4xeyA-3kulA:
35.8		 4xeyA-3kulA:
31.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
MET A 688
ILE A 711
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.56A 4xeyA-3kulA:
35.8		 4xeyA-3kulA:
31.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
MET A 688
ILE A 711
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.55A 4xeyB-3kulA:
35.2		 4xeyB-3kulA:
31.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
MET A 688
THR A 713
TYR A 715
MET A 716
GLY A 719
LEU A 767
 None
None
None
GOL  A 403 (-4.1A)
None
GOL  A 403 (-3.4A)
None
 0.51A 4xliA-3kulA:
36.3		 4xliA-3kulA:
34.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.78A 4xliB-3kulA:
36.0		 4xliB-3kulA:
34.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
LYS A 667
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.59A 4xliB-3kulA:
36.0		 4xliB-3kulA:
34.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
LYS A 667
THR A 713
ASP A 778
PHE A 779
 None
 0.88A 4xv2A-3kulA:
28.3		 4xv2A-3kulA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ALA A 665
LYS A 667
THR A 713
ASP A 778
PHE A 779
 None
 0.72A 4xv2B-3kulA:
23.0		 4xv2B-3kulA:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 9 VAL A 649
ALA A 665
MET A 716
GLY A 719
LEU A 767
ASP A 778
 None
None
None
GOL  A 403 (-3.4A)
None
None
 0.58A 5aaaA-3kulA:
33.1		 5aaaA-3kulA:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		10 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 697
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.85A 5bvwA-3kulA:
26.7		 5bvwA-3kulA:
36.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 VAL A 649
ALA A 665
LYS A 667
THR A 713
PHE A 779
 None
 0.86A 5cswB-3kulA:
28.2		 5cswB-3kulA:
33.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 ILE A 888
GLY A 745
ARG A 742
GLU A 830
LEU A 741
 None
None
SO4  A   1 (-3.3A)
None
None
 1.46A 5fhzD-3kulA:
undetectable		 5fhzD-3kulA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
ILE A 711
THR A 713
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.82A 5h2uB-3kulA:
30.6		 5h2uB-3kulA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
THR A 713
GLY A 719
LEU A 767
ASP A 778
 None
None
None
GOL  A 403 (-3.4A)
None
None
 0.64A 5h2uD-3kulA:
30.5		 5h2uD-3kulA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 ALA A 665
ILE A 697
ILE A 711
THR A 713
TYR A 715
PHE A 779
 None
None
None
None
GOL  A 403 (-4.1A)
None
 0.84A 5hesA-3kulA:
10.6		 5hesA-3kulA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
ILE A 697
ILE A 711
THR A 713
PHE A 779
GLY A 780
 None
 1.09A 5hesA-3kulA:
10.6		 5hesA-3kulA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
GLY A 780
 None
 1.08A 5hesB-3kulA:
26.8		 5hesB-3kulA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
PHE A 779
 None
 0.75A 5hesB-3kulA:
26.8		 5hesB-3kulA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		6 / 12 ALA A 665
LYS A 667
GLU A 684
THR A 713
LEU A 751
HIS A 758
 None
 0.73A 5hi2A-3kulA:
20.1		 5hi2A-3kulA:
32.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
 None
 0.78A 5hieA-3kulA:
27.4		 5hieA-3kulA:
33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
 None
 0.80A 5hieB-3kulA:
27.4		 5hieB-3kulA:
33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		5 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
 None
 0.78A 5hieD-3kulA:
27.4		 5hieD-3kulA:
33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 ALA A 665
ILE A 697
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.51A 5i9xA-3kulA:
35.5		 5i9xA-3kulA:
59.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
LYS A 667
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.65A 5i9xA-3kulA:
35.5		 5i9xA-3kulA:
59.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
LYS A 667
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.65A 5i9yA-3kulA:
35.2		 5i9yA-3kulA:
59.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 ALA A 665
LYS A 667
THR A 713
TYR A 715
GLY A 719
LEU A 767
SER A 777
 None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
None
 0.65A 5i9yA-3kulA:
35.2		 5i9yA-3kulA:
59.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		3 / 3 ILE A 697
ILE A 711
MET A 716
 None
 0.36A 5i9yA-3kulA:
35.2		 5i9yA-3kulA:
59.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		4 / 8 ALA A 665
GLU A 684
LEU A 767
ASP A 778
 None
 0.34A 5owrA-3kulA:
22.7		 5owrA-3kulA:
25.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
ILE A 711
THR A 713
GLY A 719
LEU A 767
PHE A 779
 None
None
None
None
GOL  A 403 (-3.4A)
None
None
 1.20A 5p9iA-3kulA:
31.7		 5p9iA-3kulA:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
THR A 713
GLY A 719
LEU A 767
SER A 777
PHE A 779
 None
None
None
GOL  A 403 (-3.4A)
None
None
None
 1.13A 5p9iA-3kulA:
31.7		 5p9iA-3kulA:
39.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		3 / 3 HIS A 758
SER A 777
ARG A 764
 None
 1.03A 5u63A-3kulA:
undetectable		 5u63A-3kulA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
THR A 713
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.74A 5y80A-3kulA:
24.4		 5y80A-3kulA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		3 / 3 TYR A 715
LEU A 767
ASP A 778
 GOL  A 403 (-4.1A)
None
None
 0.59A 5zv2B-3kulA:
28.3		 5zv2B-3kulA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		11 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 697
THR A 713
TYR A 715
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
GOL  A 403 (-3.4A)
None
 0.84A 6bsdA-3kulA:
26.2		 6bsdA-3kulA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		3 / 3 ARG A 882
HIS A 876
ARG A 856
 None
 1.19A 6dwdD-3kulA:
undetectable		 6dwdD-3kulA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
ILE A 711
THR A 713
MET A 716
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.63A 6fnmA-3kulA:
36.0		 6fnmA-3kulA:
64.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		8 / 12 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
MET A 716
LEU A 767
SER A 777
 None
 0.75A 6fnmA-3kulA:
36.0		 6fnmA-3kulA:
64.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
LEU A 767
 None
 0.65A 6hd4A-3kulA:
31.4		 6hd4A-3kulA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
 None
 0.77A 6hd4A-3kulA:
31.4		 6hd4A-3kulA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
LEU A 767
 None
 0.67A 6hd4B-3kulA:
31.1		 6hd4B-3kulA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
 None
 0.85A 6hd4B-3kulA:
31.1		 6hd4B-3kulA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
LEU A 767
 None
 0.64A 6hd6A-3kulA:
31.3		 6hd6A-3kulA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens) 		7 / 12 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
 None
 0.77A 6hd6A-3kulA:
31.3		 6hd6A-3kulA:
11.81