SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 6 TYR A  45
GLY A  44
ASP A 108
GLY A 351
 None
 0.96A 1eswA-3kumA:
undetectable		 1eswA-3kumA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 12 LEU A 118
LEU A 344
ILE A 301
GLY A 300
LEU A 265
 None
 1.13A 1g50B-3kumA:
undetectable		 1g50B-3kumA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 11 LEU A 118
LEU A 344
ILE A 301
GLY A 300
LEU A 265
 None
 1.12A 1g50C-3kumA:
undetectable		 1g50C-3kumA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 6 THR A 322
GLY A 333
THR A 302
ILE A 352
 None
 0.82A 1gtnD-3kumA:
undetectable
1gtnE-3kumA:
undetectable		 1gtnD-3kumA:
11.40
1gtnE-3kumA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 9 VAL A 330
GLY A 333
THR A 302
ILE A 352
THR A 322
 None
 1.16A 1gtnL-3kumA:
undetectable
1gtnM-3kumA:
undetectable		 1gtnL-3kumA:
11.40
1gtnM-3kumA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 8 GLY A 333
THR A 302
ILE A 352
THR A 322
 None
 0.82A 1gtnP-3kumA:
undetectable
1gtnQ-3kumA:
undetectable		 1gtnP-3kumA:
11.40
1gtnQ-3kumA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 12 ILE A  33
ILE A 299
TYR A  45
ALA A 328
GLU A  35
 None
 1.47A 1ki7A-3kumA:
undetectable		 1ki7A-3kumA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 7 ASP A 108
GLY A 300
ALA A 274
ILE A 271
 None
 0.66A 1n49A-3kumA:
undetectable		 1n49A-3kumA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 6 ASP A 108
GLY A 300
ILE A 301
ILE A 271
 None
 0.88A 1n49D-3kumA:
undetectable		 1n49D-3kumA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 5 LEU A 206
ILE A 160
ILE A 176
ALA A 175
 None
 0.68A 2i2zA-3kumA:
undetectable		 2i2zA-3kumA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 4 LEU A 206
ILE A 160
ILE A 176
ALA A 175
 None
 0.80A 2i30A-3kumA:
undetectable		 2i30A-3kumA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 12 LEU A 118
LEU A 344
ILE A 301
GLY A 300
LEU A 265
 None
 1.09A 2j7xA-3kumA:
undetectable		 2j7xA-3kumA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 12 ILE A 211
ARG A 187
VAL A 151
LEU A 186
GLN A 145
 None
 1.29A 2rctA-3kumA:
undetectable		 2rctA-3kumA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 7 PHE A  69
ILE A  73
THR A  62
GLY A 269
 None
 0.90A 2v0mB-3kumA:
undetectable		 2v0mB-3kumA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 12 LEU A 118
LEU A 344
ILE A 301
GLY A 300
LEU A 265
 None
 1.08A 2yjaB-3kumA:
undetectable		 2yjaB-3kumA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 7 ILE A  54
ILE A 301
LEU A  23
LEU A  15
 TYR  A 356 (-4.5A)
None
None
None
 0.97A 3adxA-3kumA:
undetectable		 3adxA-3kumA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 12 ASP A 248
ILE A 261
ILE A 104
ILE A 263
ALA A 246
 None
 1.22A 3ohtA-3kumA:
undetectable
3ohtB-3kumA:
undetectable		 3ohtA-3kumA:
21.38
3ohtB-3kumA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 12 LEU A  63
GLY A  48
ALA A 101
ILE A  36
ILE A  66
 None
 1.04A 3oxxC-3kumA:
undetectable		 3oxxC-3kumA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 10 ILE A  66
ALA A 101
ILE A  54
ILE A 290
ILE A 277
 None
None
TYR  A 356 (-4.5A)
None
None
 1.11A 3prsA-3kumA:
undetectable		 3prsA-3kumA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 12 LEU A 118
LEU A 344
ILE A 301
GLY A 300
LEU A 265
 None
 1.15A 3q95A-3kumA:
undetectable		 3q95A-3kumA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 7 ILE A 301
LEU A 342
ALA A 308
ALA A 309
 None
 0.85A 3r9tB-3kumA:
3.9		 3r9tB-3kumA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 7 LEU A 213
VAL A 260
LEU A 252
ASP A 240
 None
None
None
MG  A 357 ( 3.3A)
 0.63A 3rgfA-3kumA:
undetectable		 3rgfA-3kumA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 7 LEU A 252
VAL A 258
LEU A 213
ASP A 240
 None
None
None
MG  A 357 ( 3.3A)
 0.80A 3rgfA-3kumA:
undetectable		 3rgfA-3kumA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 8 LEU A 325
ALA A  29
SER A  31
SER A  11
 None
 1.02A 3rodA-3kumA:
undetectable		 3rodA-3kumA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 8 ILE A 203
LEU A 206
VAL A 162
GLY A 163
 None
 0.88A 3w1wA-3kumA:
3.2		 3w1wA-3kumA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 12 LEU A 118
LEU A 344
ILE A 301
GLY A 300
LEU A 265
 None
 1.05A 4j26A-3kumA:
undetectable		 4j26A-3kumA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 9 MET A 266
ALA A 321
LEU A 319
GLY A 291
ALA A 347
 None
 1.39A 4l6va-3kumA:
undetectable
4l6vf-3kumA:
undetectable		 4l6va-3kumA:
18.25
4l6vf-3kumA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 6 ASP A 318
ASP A 320
ALA A 338
ASP A 132
 ARG  A 355 (-2.8A)
ARG  A 355 (-3.3A)
None
None
 1.05A 4mdaA-3kumA:
undetectable		 4mdaA-3kumA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 6 ASP A 318
ASP A 320
ALA A 338
ASP A 132
 ARG  A 355 (-2.8A)
ARG  A 355 (-3.3A)
None
None
 1.02A 4mdbA-3kumA:
undetectable		 4mdbA-3kumA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		3 / 3 PRO A  78
VAL A   6
HIS A   7
 None
 0.71A 4pevC-3kumA:
2.7		 4pevC-3kumA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 10 LEU A 350
LEU A 319
ALA A 321
ALA A 305
GLY A 300
 None
 1.47A 4rn6A-3kumA:
undetectable		 4rn6A-3kumA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 11 LEU A 118
LEU A 344
ILE A 301
GLY A 300
LEU A 265
 None
 1.10A 5dxbB-3kumA:
undetectable		 5dxbB-3kumA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 9 ILE A 314
ALA A 310
ILE A 271
ALA A 274
LEU A 275
 None
 1.04A 5mvmA-3kumA:
undetectable
5mvmE-3kumA:
undetectable		 5mvmA-3kumA:
16.79
5mvmE-3kumA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		4 / 6 ILE A 263
ALA A 304
LEU A 307
ILE A 271
 None
 0.74A 5mvmB-3kumA:
undetectable
5mvmC-3kumA:
undetectable		 5mvmB-3kumA:
16.79
5mvmC-3kumA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		3 / 3 SER A  28
ALA A  29
THR A 297
 None
 0.62A 5n0xB-3kumA:
undetectable		 5n0xB-3kumA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		3 / 3 ASP A 240
ASN A 262
ASP A 318
 MG  A 357 ( 3.3A)
None
ARG  A 355 (-2.8A)
 0.84A 5vopB-3kumA:
3.4		 5vopB-3kumA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3kum DIPEPTIDE EPIMERASE
(Enterococcus
faecalis) 		5 / 12 LEU A  63
GLU A  35
VAL A   8
ARG A   9
THR A 327
 None
 1.48A 5xiqB-3kumA:
undetectable		 5xiqB-3kumA:
20.82