SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kuq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		5 / 10 LEU A1125
ASN A1129
GLN A1093
LEU A1102
PHE A1076
 None
 1.36A 1zucA-3kuqA:
undetectable		 1zucA-3kuqA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 8 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.84A 2eijN-3kuqA:
undetectable
2eijW-3kuqA:
undetectable		 2eijN-3kuqA:
17.51
2eijW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 8 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.87A 2einA-3kuqA:
undetectable
2einJ-3kuqA:
undetectable		 2einA-3kuqA:
17.51
2einJ-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 6 ARG A1114
ASN A1266
PRO A1231
ALA A1230
 None
 1.02A 2ejfB-3kuqA:
undetectable		 2ejfB-3kuqA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 7 ARG A1114
ASN A1266
PRO A1231
ALA A1230
 None
 1.01A 2ejgA-3kuqA:
undetectable		 2ejgA-3kuqA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 8 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.84A 3abkA-3kuqA:
undetectable
3abkJ-3kuqA:
undetectable		 3abkA-3kuqA:
17.51
3abkJ-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 8 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.91A 3ablN-3kuqA:
undetectable
3ablW-3kuqA:
undetectable		 3ablN-3kuqA:
17.51
3ablW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 8 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.79A 3abmN-3kuqA:
undetectable
3abmW-3kuqA:
undetectable		 3abmN-3kuqA:
17.51
3abmW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 8 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.84A 3asnN-3kuqA:
undetectable
3asnW-3kuqA:
undetectable		 3asnN-3kuqA:
17.51
3asnW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 8 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.84A 3asoN-3kuqA:
undetectable
3asoW-3kuqA:
undetectable		 3asoN-3kuqA:
17.51
3asoW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		5 / 11 VAL A1078
ILE A1095
SER A1094
PRO A1092
THR A1087
 None
 1.29A 3bjwB-3kuqA:
undetectable		 3bjwB-3kuqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		5 / 11 VAL A1078
ILE A1095
SER A1094
PRO A1092
THR A1087
 None
 1.30A 3bjwE-3kuqA:
undetectable		 3bjwE-3kuqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		5 / 12 VAL A1078
ILE A1095
SER A1094
PRO A1092
THR A1087
 None
 1.25A 3bjwF-3kuqA:
undetectable		 3bjwF-3kuqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		5 / 11 VAL A1078
ILE A1095
SER A1094
PRO A1092
THR A1087
 None
 1.28A 3bjwH-3kuqA:
undetectable		 3bjwH-3kuqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 6 PHE A1170
PHE A1234
ALA A1274
LEU A1205
 None
 1.04A 4ejgD-3kuqA:
undetectable		 4ejgD-3kuqA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		3 / 3 MET A1099
MET A1128
TYR A1153
 None
 1.17A 4p6xI-3kuqA:
undetectable		 4p6xI-3kuqA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 7 PHE A1154
SER A1232
ALA A1147
LEU A1150
 None
 1.06A 4xk8A-3kuqA:
undetectable		 4xk8A-3kuqA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 7 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.75A 5b1bN-3kuqA:
undetectable
5b1bW-3kuqA:
undetectable		 5b1bN-3kuqA:
17.51
5b1bW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 7 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.86A 5b3sN-3kuqA:
undetectable
5b3sW-3kuqA:
undetectable		 5b3sN-3kuqA:
17.51
5b3sW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 6 PHE A1207
MET A1099
LEU A1205
LEU A1208
 None
 1.33A 5dzke-3kuqA:
undetectable
5dzks-3kuqA:
undetectable		 5dzke-3kuqA:
24.90
5dzks-3kuqA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 7 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.91A 5iy5N-3kuqA:
undetectable
5iy5W-3kuqA:
undetectable		 5iy5N-3kuqA:
17.51
5iy5W-3kuqA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 8 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.91A 5xdxN-3kuqA:
undetectable
5xdxW-3kuqA:
undetectable		 5xdxN-3kuqA:
17.51
5xdxW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 8 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.87A 5zcpN-3kuqA:
undetectable
5zcpW-3kuqA:
undetectable		 5zcpN-3kuqA:
17.51
5zcpW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		4 / 8 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.77A 5zcqN-3kuqA:
undetectable
5zcqW-3kuqA:
undetectable		 5zcqN-3kuqA:
17.51
5zcqW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens) 		3 / 3 TYR A1174
HIS A1275
MET A1276
 None
 1.21A 6af6A-3kuqA:
undetectable		 6af6A-3kuqA:
19.79