SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kuu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		5 / 9 THR A  27
GLY A 127
GLY A  76
SER A 108
GLY A  74
 SO4  A 175 ( 4.2A)
SO4  A 175 (-3.5A)
None
None
None
 1.33A 1jhoA-3kuuA:
5.0		 1jhoA-3kuuA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		4 / 4 THR A  27
GLY A 105
ASP A 107
ALA A 101
 SO4  A 175 ( 4.2A)
None
None
SO4  A 176 (-3.5A)
 0.79A 1sg9A-3kuuA:
4.1		 1sg9A-3kuuA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		5 / 12 GLY A 130
ALA A 131
ILE A  17
GLY A  74
ALA A  26
 None
 0.91A 2nmzB-3kuuA:
undetectable		 2nmzB-3kuuA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		5 / 12 LEU A  94
ALA A  31
LEU A  38
VAL A  70
ILE A  72
 None
 0.95A 3em6B-3kuuA:
undetectable		 3em6B-3kuuA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		4 / 8 SER A 108
ASP A  24
VAL A  18
LEU A  85
 None
 1.14A 3jq7C-3kuuA:
2.9		 3jq7C-3kuuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		4 / 5 VAL A  34
LEU A  35
ILE A  72
ALA A 134
 None
 0.92A 3n8yB-3kuuA:
undetectable		 3n8yB-3kuuA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		5 / 12 GLY A 122
GLY A  95
LYS A  14
HIS A  69
VAL A  40
 None
 0.96A 5njvC-3kuuA:
undetectable		 5njvC-3kuuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		5 / 12 GLY A 122
GLY A  95
LYS A  14
HIS A  69
VAL A  40
 None
 0.96A 5wz1A-3kuuA:
undetectable		 5wz1A-3kuuA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		5 / 12 GLY A 122
GLY A  95
LYS A  14
HIS A  69
VAL A  40
 None
 0.94A 5wz1C-3kuuA:
undetectable		 5wz1C-3kuuA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		5 / 12 GLY A 122
GLY A  95
LYS A  14
HIS A  69
VAL A  40
 None
 0.95A 5wz1D-3kuuA:
undetectable		 5wz1D-3kuuA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		5 / 12 GLY A 122
GLY A  95
LYS A  14
HIS A  69
VAL A  40
 None
 0.93A 5wz1E-3kuuA:
undetectable		 5wz1E-3kuuA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		5 / 12 GLY A 122
GLY A  95
LYS A  14
HIS A  69
VAL A  40
 None
 0.95A 5wz1F-3kuuA:
undetectable		 5wz1F-3kuuA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		5 / 12 GLY A 122
GLY A  95
LYS A  14
HIS A  69
VAL A  40
 None
 0.92A 5wz1G-3kuuA:
undetectable		 5wz1G-3kuuA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE
(Yersinia
pestis) 		5 / 12 GLY A 122
GLY A  95
LYS A  14
HIS A  69
VAL A  40
 None
 0.95A 5wz1H-3kuuA:
undetectable		 5wz1H-3kuuA:
21.30