SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 7 PHE A 250
ARG A 237
TYR A 247
GLY A 277
 None
 0.88A 11gsA-3kuxA:
undetectable		 11gsA-3kuxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 8 ALA A 236
GLY A 277
ILE A 278
ILE A 239
 None
 0.71A 1d4yB-3kuxA:
undetectable		 1d4yB-3kuxA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 8 ALA A 185
LEU A 225
ARG A 237
LEU A 329
 None
 0.86A 1ereE-3kuxA:
undetectable		 1ereE-3kuxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 8 ALA A 185
LEU A 225
ARG A 237
LEU A 329
 None
 0.84A 1ereF-3kuxA:
undetectable		 1ereF-3kuxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 VAL A  35
GLY A  34
LEU A  32
GLY A  11
LEU A  23
 None
 1.09A 1fduA-3kuxA:
3.6		 1fduA-3kuxA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 6 THR A 132
LEU A 136
LYS A 249
TYR A 247
 None
 1.04A 1gtiC-3kuxA:
undetectable		 1gtiC-3kuxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 SER A 119
PHE A 121
LEU A  23
TYR A 302
LEU A   9
 None
 1.44A 1p33C-3kuxA:
8.4		 1p33C-3kuxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 8 PHE A 250
ARG A 237
TYR A 247
GLY A 277
 None
 0.87A 2gssA-3kuxA:
undetectable		 2gssA-3kuxA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 8 PHE A 250
ARG A 237
TYR A 247
GLY A 277
 None
 0.88A 2gssB-3kuxA:
undetectable		 2gssB-3kuxA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 6 LEU A  67
ILE A  24
ARG A 307
ILE A   5
 None
 0.92A 2q8hA-3kuxA:
undetectable		 2q8hA-3kuxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 8 PRO A  79
ALA A  81
ALA A  84
THR A  72
 None
 0.69A 3dtuC-3kuxA:
undetectable
3dtuD-3kuxA:
undetectable		 3dtuC-3kuxA:
20.51
3dtuD-3kuxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 9 ASP A 337
GLY A 172
ILE A 173
PRO A  96
ILE A 330
 None
 1.31A 3ekyB-3kuxA:
undetectable		 3ekyB-3kuxA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 5 THR A 321
ILE A 324
LYS A 325
GLU A 328
 None
 0.86A 4ac9C-3kuxA:
4.5		 4ac9C-3kuxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 5 THR A 321
ILE A 324
LYS A 325
GLU A 328
 None
 0.87A 4acaC-3kuxA:
4.1		 4acaC-3kuxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 5 THR A 321
ILE A 324
LYS A 325
GLU A 328
 None
 0.89A 4acbC-3kuxA:
6.3		 4acbC-3kuxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		3 / 3 TYR A 302
ARG A 125
HIS A 122
 None
 1.26A 4fubA-3kuxA:
undetectable		 4fubA-3kuxA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 ILE A  65
TYR A 303
PHE A 121
LEU A 259
LEU A  32
 None
 1.04A 4j03A-3kuxA:
4.4		 4j03A-3kuxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 LEU A  80
PHE A  60
PRO A  71
ASP A  62
GLY A   8
 None
 1.35A 4j7xA-3kuxA:
7.1		 4j7xA-3kuxA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 LEU A 343
LEU A 195
ASN A 196
LEU A 216
LEU A 199
 None
 1.20A 4ltwA-3kuxA:
undetectable		 4ltwA-3kuxA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 5 LEU A 118
ALA A 104
ASN A 105
ILE A 324
 None
 1.07A 4y03B-3kuxA:
undetectable		 4y03B-3kuxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 10 GLY A 140
SER A 141
LEU A 142
LEU A 292
TYR A 247
 None
 1.30A 5hwkA-3kuxA:
undetectable		 5hwkA-3kuxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 10 GLY A 245
GLY A 242
LEU A 142
LEU A 133
TYR A 247
 None
 1.17A 5hwkA-3kuxA:
undetectable		 5hwkA-3kuxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 10 GLY A 140
SER A 141
LEU A 142
LEU A 292
TYR A 247
 None
 1.30A 5hwkB-3kuxA:
undetectable		 5hwkB-3kuxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 10 GLY A 245
GLY A 242
LEU A 142
LEU A 133
TYR A 247
 None
 1.18A 5hwkB-3kuxA:
undetectable		 5hwkB-3kuxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 PHE A 212
LEU A 195
ALA A 214
LEU A 225
ILE A 330
 None
 1.13A 5ljcA-3kuxA:
undetectable		 5ljcA-3kuxA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_1
(OXAC)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 5 TYR A 238
HIS A 180
ASP A 127
ASP A 273
 None
 1.27A 5w7pA-3kuxA:
4.6		 5w7pA-3kuxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3kux PUTATIVE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 GLY A 143
GLY A 140
VAL A 279
GLY A 245
GLY A 242
 None
 1.04A 5wyqA-3kuxA:
undetectable		 5wyqA-3kuxA:
20.22