SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 3kv0 HET-C2
(Podospora
anserina) 		5 / 12 GLU A  46
LEU A  42
ARG A  75
ILE A  36
LEU A 190
 None
 1.13A 1g50B-3kv0A:
undetectable		 1g50B-3kv0A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 3kv0 HET-C2
(Podospora
anserina) 		5 / 11 GLU A  46
LEU A  42
ARG A  75
ILE A  36
LEU A 190
 None
 1.12A 1g50C-3kv0A:
undetectable		 1g50C-3kv0A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 3kv0 HET-C2
(Podospora
anserina) 		4 / 6 HIS A 147
LEU A 143
PHE A 155
VAL A 151
 None
MLY  A 144 ( 4.3A)
None
MLY  A 152 ( 3.2A)
 1.00A 1ibgH-3kv0A:
undetectable		 1ibgH-3kv0A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3kv0 HET-C2
(Podospora
anserina) 		4 / 7 LEU A  79
ILE A  36
THR A  38
GLN A  89
 MLY  A  76 ( 4.6A)
None
None
None
 1.22A 1kglA-3kv0A:
undetectable		 1kglA-3kv0A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3kv0 HET-C2
(Podospora
anserina) 		5 / 10 GLU A  46
LEU A  42
ARG A  75
ILE A  36
LEU A 190
 None
 1.08A 1qkuA-3kv0A:
undetectable		 1qkuA-3kv0A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3kv0 HET-C2
(Podospora
anserina) 		5 / 10 GLU A  46
LEU A  42
ARG A  75
ILE A  36
LEU A 190
 None
 1.08A 1qkuB-3kv0A:
undetectable		 1qkuB-3kv0A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3kv0 HET-C2
(Podospora
anserina) 		5 / 10 GLU A  46
LEU A  42
ARG A  75
ILE A  36
LEU A 190
 None
 1.07A 1qkuC-3kv0A:
undetectable		 1qkuC-3kv0A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3kv0 HET-C2
(Podospora
anserina) 		3 / 3 MET A  51
ASN A 124
GLN A 180
 None
 1.06A 1xoqB-3kv0A:
undetectable		 1xoqB-3kv0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 3kv0 HET-C2
(Podospora
anserina) 		5 / 11 MET A  67
LEU A 197
ILE A  88
THR A  49
VAL A  26
 None
MLY  A 198 ( 4.3A)
None
MLY  A  64 ( 4.3A)
None
 1.19A 2qd3A-3kv0A:
undetectable		 2qd3A-3kv0A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 3kv0 HET-C2
(Podospora
anserina) 		4 / 6 PHE A 135
MET A 159
PHE A  60
PHE A  52
 None
None
None
MLY  A  64 ( 4.5A)
 1.32A 3af3A-3kv0A:
undetectable		 3af3A-3kv0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 3kv0 HET-C2
(Podospora
anserina) 		5 / 12 LEU A 190
LEU A 121
GLY A 113
SER A 138
PHE A  60
 None
 1.32A 3tbgA-3kv0A:
1.7		 3tbgA-3kv0A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3kv0 HET-C2
(Podospora
anserina) 		4 / 7 LEU A 172
TYR A 186
LEU A 121
TYR A 169
 MLY  A 171 ( 4.1A)
None
None
None
 0.98A 4b3qA-3kv0A:
undetectable		 4b3qA-3kv0A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kv0 HET-C2
(Podospora
anserina) 		5 / 12 MET A  67
LEU A 197
ILE A  88
THR A  49
VAL A  26
 None
MLY  A 198 ( 4.3A)
None
MLY  A  64 ( 4.3A)
None
 1.18A 4f4dA-3kv0A:
undetectable		 4f4dA-3kv0A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kv0 HET-C2
(Podospora
anserina) 		5 / 12 MET A  67
LEU A 197
ILE A  88
THR A  49
VAL A  26
 None
MLY  A 198 ( 4.3A)
None
MLY  A  64 ( 4.3A)
None
 1.19A 4f4dB-3kv0A:
undetectable		 4f4dB-3kv0A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3kv0 HET-C2
(Podospora
anserina) 		4 / 4 LEU A  68
VAL A  71
GLU A  72
ARG A  75
 MLY  A  64 ( 3.5A)
None
MLY  A  76 ( 4.7A)
None
 1.32A 4ww7A-3kv0A:
undetectable		 4ww7A-3kv0A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3kv0 HET-C2
(Podospora
anserina) 		5 / 12 LEU A 121
PHE A 168
LEU A  16
THR A  49
MET A  51
 None
None
None
MLY  A  64 ( 4.3A)
None
 1.22A 4ze1A-3kv0A:
undetectable		 4ze1A-3kv0A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 3kv0 HET-C2
(Podospora
anserina) 		4 / 4 VAL A 179
GLU A 182
GLY A 173
LEU A 172
 MLY  A 178 ( 3.4A)
None
MLY  A 171 ( 4.6A)
MLY  A 171 ( 4.1A)
 1.31A 5g5gC-3kv0A:
undetectable		 5g5gC-3kv0A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3kv0 HET-C2
(Podospora
anserina) 		3 / 3 ASP A  90
ASN A  87
ASP A  29
 None
None
MLY  A  32 ( 3.8A)
 0.67A 5vopA-3kv0A:
undetectable		 5vopA-3kv0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3kv0 HET-C2
(Podospora
anserina) 		3 / 3 ASP A  90
ASN A  87
ASP A  29
 None
None
MLY  A  32 ( 3.8A)
 0.70A 5vopB-3kv0A:
undetectable		 5vopB-3kv0A:
23.59