SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 5 LEU A 429
LEU A 433
LEU A 393
GLY A 372
 None
 1.02A 1a4lC-3kv4A:
undetectable		 1a4lC-3kv4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 4 SER A 192
VAL A 231
PHE A 359
VAL A  16
 None
 1.18A 1o86A-3kv4A:
4.1		 1o86A-3kv4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 12 GLY A 308
LEU A 137
LEU A 328
CYH A 327
THR A 323
 None
 1.46A 1p93C-3kv4A:
undetectable		 1p93C-3kv4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		3 / 3 TRP A 282
THR A  82
TYR A 243
 None
 1.21A 2a3aA-3kv4A:
undetectable		 2a3aA-3kv4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		3 / 3 TRP A 282
THR A  82
TYR A 243
 None
 1.16A 2a3aB-3kv4A:
undetectable		 2a3aB-3kv4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		3 / 3 TRP A 282
THR A  82
TYR A 243
 None
 1.22A 2a3bA-3kv4A:
undetectable		 2a3bA-3kv4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 12 SER A 337
GLY A 372
GLY A 397
VAL A 424
THR A 423
 EDO  A 459 (-2.8A)
None
None
None
None
 1.01A 2nyuB-3kv4A:
undetectable		 2nyuB-3kv4A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 6 ASP A 249
HIS A 319
TYR A 257
ASN A 189
 FE2  A 450 ( 2.5A)
FE2  A 450 ( 3.4A)
OGA  A5798 (-4.2A)
OGA  A5798 (-3.7A)
 1.14A 2zs9A-3kv4A:
undetectable		 2zs9A-3kv4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 8 LEU A 276
ILE A 318
PHE A 246
GLY A 294
 None
 0.91A 3b9lA-3kv4A:
3.1		 3b9lA-3kv4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 12 GLY A 251
ALA A 346
THR A 315
GLU A 350
ASP A 357
 None
None
None
None
EDO  A 463 ( 4.5A)
 1.01A 3id6C-3kv4A:
undetectable		 3id6C-3kv4A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		7 / 10 LEU A 236
THR A 244
HIS A 247
ASP A 249
LYS A 264
ILE A 313
HIS A 319
 OGA  A5798 ( 4.8A)
OGA  A5798 (-3.4A)
FE2  A 450 ( 3.4A)
FE2  A 450 ( 2.5A)
OGA  A5798 (-2.8A)
None
FE2  A 450 ( 3.4A)
 0.98A 3kcxA-3kv4A:
16.7		 3kcxA-3kv4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 5 ILE A 103
PHE A 293
SER A 304
ASP A  97
 None
 1.44A 4rzvB-3kv4A:
undetectable		 4rzvB-3kv4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 6 PHE A 361
ARG A 360
PHE A 364
TYR A 347
 None
 1.48A 4uciA-3kv4A:
undetectable		 4uciA-3kv4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 7 PHE A 361
ARG A 360
PHE A 364
TYR A 347
 None
 1.48A 4uciB-3kv4A:
undetectable		 4uciB-3kv4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 7 GLY A 396
GLY A 397
ALA A 399
ILE A 437
 None
 0.65A 4yjiA-3kv4A:
undetectable		 4yjiA-3kv4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 5 PHE A 361
ASP A 249
PHE A 250
VAL A 231
 None
FE2  A 450 ( 2.5A)
None
None
 1.13A 5a1rA-3kv4A:
undetectable		 5a1rA-3kv4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 6 HIS A  49
LEU A  47
CYH A  26
CYH A  53
 None
None
ZN  A 449 (-1.9A)
ZN  A 449 (-2.4A)
 1.45A 5hrqD-3kv4A:
undetectable
5hrqG-3kv4A:
undetectable
5hrqH-3kv4A:
undetectable		 5hrqD-3kv4A:
5.29
5hrqG-3kv4A:
4.33
5hrqH-3kv4A:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		3 / 3 ARG A 380
ILE A 375
PHE A 379
 None
 0.74A 5kirA-3kv4A:
undetectable		 5kirA-3kv4A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 12 GLY A 108
GLY A 132
ILE A 209
VAL A 127
ILE A 125
 None
EDO  A 458 (-3.5A)
None
None
None
 0.88A 6ecxA-3kv4A:
undetectable		 6ecxA-3kv4A:
22.56