SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 8 ASN A 372
LEU A 435
ALA A 438
LEU A 439
 None
 0.66A 1hwiB-3kv6A:
undetectable		 1hwiB-3kv6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 8 ASN A 372
LEU A 435
ALA A 438
LEU A 439
 None
 0.68A 1hwiD-3kv6A:
undetectable		 1hwiD-3kv6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 8 ASN A 372
LEU A 435
ALA A 438
LEU A 439
 None
 0.67A 1hwiC-3kv6A:
undetectable		 1hwiC-3kv6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 7 PRO A 424
LEU A 428
GLY A 431
LEU A 414
 None
 0.80A 1ya4B-3kv6A:
undetectable		 1ya4B-3kv6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		3 / 3 LYS A 221
ASP A  56
ASP A  76
 None
 0.94A 2br4D-3kv6A:
undetectable		 2br4D-3kv6A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 5 ASP A 308
LEU A 311
MET A 384
ARG A 380
 None
 1.20A 2gj5A-3kv6A:
undetectable		 2gj5A-3kv6A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		3 / 3 GLN A 360
LYS A 299
VAL A 339
 None
AKG  A 702 (-3.6A)
None
 0.88A 2jfaB-3kv6A:
undetectable		 2jfaB-3kv6A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 5 ALA A 407
GLY A 431
LYS A 433
HIS A 436
 None
 1.47A 2ylgA-3kv6A:
undetectable		 2ylgA-3kv6A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		5 / 8 LEU A 311
ILE A 353
PHE A 281
ARG A 313
GLY A 329
 None
 0.98A 3b9lA-3kv6A:
undetectable		 3b9lA-3kv6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		5 / 12 HIS A 354
HIS A 282
VAL A 348
VAL A 290
VAL A 340
 FE2  A 491 (-3.4A)
FE2  A 491 ( 3.6A)
None
None
None
 1.01A 3czvA-3kv6A:
undetectable
3czvB-3kv6A:
undetectable		 3czvA-3kv6A:
19.34
3czvB-3kv6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		6 / 10 LEU A 271
THR A 279
HIS A 282
ASP A 284
LYS A 299
HIS A 354
 AKG  A 702 ( 4.7A)
AKG  A 702 (-4.2A)
FE2  A 491 ( 3.6A)
FE2  A 491 ( 2.6A)
AKG  A 702 (-3.6A)
FE2  A 491 (-3.4A)
 0.93A 3kcxA-3kv6A:
15.2		 3kcxA-3kv6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 7 LEU A 223
ASP A 196
GLU A  71
HIS A  73
 None
 1.15A 4aq7A-3kv6A:
undetectable		 4aq7A-3kv6A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 7 HIS A 354
ALA A 355
VAL A 356
ALA A 117
 FE2  A 491 (-3.4A)
None
AKG  A 702 (-4.0A)
None
 0.61A 4g77A-3kv6A:
undetectable		 4g77A-3kv6A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 5 LEU A 271
ASP A 284
GLU A 229
VAL A 241
 AKG  A 702 ( 4.7A)
FE2  A 491 ( 2.6A)
None
None
 0.84A 4nkvA-3kv6A:
undetectable		 4nkvA-3kv6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 5 LEU A 271
ASP A 284
GLU A 229
VAL A 241
 AKG  A 702 ( 4.7A)
FE2  A 491 ( 2.6A)
None
None
 0.81A 4nkxB-3kv6A:
undetectable		 4nkxB-3kv6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		5 / 12 THR A 288
GLY A 367
PRO A 242
ALA A 245
PHE A 365
 None
OXY  A 492 ( 4.7A)
None
None
None
 1.01A 4rvgA-3kv6A:
undetectable		 4rvgA-3kv6A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 4 CYH A 403
LEU A 379
LEU A 435
ALA A 434
 None
 1.10A 5hpuA-3kv6A:
undetectable
5hpuB-3kv6A:
undetectable		 5hpuA-3kv6A:
4.37
5hpuB-3kv6A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		5 / 12 VAL A 294
HIS A 293
LEU A 172
VAL A 239
GLY A 367
 None
None
None
None
OXY  A 492 ( 4.7A)
 1.46A 5i8fA-3kv6A:
undetectable		 5i8fA-3kv6A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		4 / 6 GLU A 125
ARG A 129
PHE A 327
VAL A 326
 None
 1.41A 6fgdA-3kv6A:
undetectable		 6fgdA-3kv6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens) 		3 / 3 LYS A 204
VAL A 191
ASP A 193
 None
 0.37A 6fgdA-3kv6A:
undetectable		 6fgdA-3kv6A:
22.31