SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 128
ASP A  74
GLY A  17
VAL A  85
ILE A  81
 None
NAP  A 501 (-3.5A)
NAP  A 501 (-3.3A)
None
None
 0.95A 1fb7A-3kvoA:
undetectable		 1fb7A-3kvoA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 GLY A 128
ASP A  74
GLY A  17
VAL A  85
ILE A  81
 None
NAP  A 501 (-3.5A)
NAP  A 501 (-3.3A)
None
None
 1.03A 1hxwA-3kvoA:
undetectable		 1hxwA-3kvoA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 ILE A 231
PHE A 232
VAL A  13
SER A 143
 None
 1.11A 1kb9A-3kvoA:
undetectable
1kb9C-3kvoA:
undetectable
1kb9D-3kvoA:
undetectable
1kb9E-3kvoA:
undetectable		 1kb9A-3kvoA:
23.06
1kb9C-3kvoA:
21.81
1kb9D-3kvoA:
22.38
1kb9E-3kvoA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A  23
VAL A  99
ALA A 225
ALA A 228
ILE A 224
 None
 1.09A 1likA-3kvoA:
7.2		 1likA-3kvoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 10 VAL A  13
VAL A  99
ALA A 225
ALA A 228
ILE A 224
 None
 1.00A 1likA-3kvoA:
7.2		 1likA-3kvoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 128
ASP A  74
GLY A  17
VAL A  85
ILE A  81
 None
NAP  A 501 (-3.5A)
NAP  A 501 (-3.3A)
None
None
 0.95A 2o4sA-3kvoA:
undetectable		 2o4sA-3kvoA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A  26
ALA A  25
GLY A  21
ILE A 224
GLY A  17
 None
None
NAP  A 501 (-3.5A)
None
NAP  A 501 (-3.3A)
 0.87A 2qe6A-3kvoA:
6.2		 2qe6A-3kvoA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A  26
ALA A  25
GLY A  21
ILE A 224
GLY A  17
 None
None
NAP  A 501 (-3.5A)
None
NAP  A 501 (-3.3A)
 0.87A 2qe6B-3kvoA:
6.2		 2qe6B-3kvoA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 PHE A  14
SER A 133
THR A 129
GLY A  17
ALA A  40
 None
None
None
NAP  A 501 (-3.3A)
None
 1.05A 2x2iA-3kvoA:
2.4		 2x2iA-3kvoA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 ALA A 191
GLY A 188
ILE A 137
LEU A 140
ALA A 146
 None
 0.84A 2z0yA-3kvoA:
2.7		 2z0yA-3kvoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 ALA A 191
GLY A 188
ILE A 137
LEU A 140
ALA A 146
 None
 0.82A 2z0yB-3kvoA:
2.6		 2z0yB-3kvoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A  17
ALA A  25
ASP A  74
VAL A  75
VAL A 124
 NAP  A 501 (-3.3A)
None
NAP  A 501 (-3.5A)
NAP  A 501 (-3.6A)
NAP  A 501 (-4.1A)
 0.95A 3dmfA-3kvoA:
7.6		 3dmfA-3kvoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A  19
LEU A  50
ALA A 205
ALA A 204
 NAP  A 501 (-2.7A)
None
NAP  A 501 (-3.3A)
None
 0.94A 3ns1L-3kvoA:
undetectable		 3ns1L-3kvoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		6 / 12 GLY A 128
ASP A  74
VAL A  73
VAL A  99
VAL A  85
ILE A  81
 None
NAP  A 501 (-3.5A)
None
None
None
None
 1.43A 3nu5A-3kvoA:
undetectable		 3nu5A-3kvoA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A  22
LEU A 249
SER A 230
LEU A 149
ILE A  26
 NAP  A 501 (-4.2A)
None
None
None
None
 1.04A 3tq9A-3kvoA:
2.6		 3tq9A-3kvoA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 4 LEU A  69
ALA A  58
ILE A  54
LYS A  87
 None
 1.47A 4eixA-3kvoA:
undetectable		 4eixA-3kvoA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 9 SER A 103
ASN A 101
ILE A  22
GLY A  21
THR A 203
 NAP  A 501 (-3.4A)
NAP  A 501 (-3.6A)
NAP  A 501 (-4.2A)
NAP  A 501 (-3.5A)
NAP  A 501 (-2.7A)
 1.29A 4fxsA-3kvoA:
undetectable		 4fxsA-3kvoA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		3 / 3 LYS A  87
LEU A  69
ALA A  84
 None
 0.72A 4iizA-3kvoA:
undetectable		 4iizA-3kvoA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		4 / 7 ALA A 104
SER A 103
VAL A  75
ARG A  76
 NAP  A 502 ( 3.7A)
NAP  A 501 (-3.4A)
NAP  A 501 (-3.6A)
NAP  A 502 (-3.0A)
 1.12A 4ijiH-3kvoA:
undetectable		 4ijiH-3kvoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 THR A 203
ALA A  18
GLY A  23
ALA A  25
ASP A 222
 NAP  A 501 (-2.7A)
None
None
None
None
 1.32A 5l5zH-3kvoA:
undetectable
5l5zI-3kvoA:
undetectable		 5l5zH-3kvoA:
20.73
5l5zI-3kvoA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 THR A 203
ALA A  18
GLY A  23
ALA A  25
ASP A 222
 NAP  A 501 (-2.7A)
None
None
None
None
 1.33A 5l5zV-3kvoA:
undetectable
5l5zW-3kvoA:
undetectable		 5l5zV-3kvoA:
20.73
5l5zW-3kvoA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 128
ASP A  74
GLY A  17
VAL A  85
ILE A  81
 None
NAP  A 501 (-3.5A)
NAP  A 501 (-3.3A)
None
None
 0.89A 6dj1A-3kvoA:
undetectable		 6dj1A-3kvoA:
13.17