SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kvy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 ARG A 137
THR A 140
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.28A 1jdvA-3kvyA:
24.8
1jdvD-3kvyA:
24.8		 1jdvA-3kvyA:
24.68
1jdvD-3kvyA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 ARG A 137
THR A 140
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.29A 1jdvB-3kvyA:
24.8
1jdvC-3kvyA:
25.4		 1jdvB-3kvyA:
24.68
1jdvC-3kvyA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 ARG A 137
THR A 140
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.29A 1jdvA-3kvyA:
24.8
1jdvD-3kvyA:
24.8		 1jdvA-3kvyA:
24.68
1jdvD-3kvyA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 12 ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.33A 1jdvE-3kvyA:
24.7
1jdvF-3kvyA:
25.4		 1jdvE-3kvyA:
24.68
1jdvF-3kvyA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.36A 1odiA-3kvyA:
16.1		 1odiA-3kvyA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 1odiB-3kvyA:
25.2		 1odiB-3kvyA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.38A 1odiC-3kvyA:
25.2		 1odiC-3kvyA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.33A 1odiD-3kvyA:
25.1		 1odiD-3kvyA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.32A 1odiE-3kvyA:
25.1		 1odiE-3kvyA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.35A 1odiF-3kvyA:
25.0		 1odiF-3kvyA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 9 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.31A 1pk7A-3kvyA:
25.3		 1pk7A-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.26A 1pk7B-3kvyA:
25.5		 1pk7B-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 10 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.29A 1pk7C-3kvyA:
13.1		 1pk7C-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 10 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.31A 1pk9A-3kvyA:
25.3		 1pk9A-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 9 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.30A 1pk9B-3kvyA:
25.4		 1pk9B-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.21A 1pk9C-3kvyA:
24.8		 1pk9C-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 10 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.29A 1pw7A-3kvyA:
25.4		 1pw7A-3kvyA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 9 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.32A 1pw7B-3kvyA:
25.4		 1pw7B-3kvyA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 ARG A 137
TYR A 213
ASP A 220
GLU A 247
 SO4  A 311 ( 3.0A)
None
None
R2B  A 313 ( 4.4A)
 1.09A 1rjdA-3kvyA:
undetectable		 1rjdA-3kvyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 ARG A 137
TYR A 213
ASP A 220
GLU A 247
 SO4  A 311 ( 3.0A)
None
None
R2B  A 313 ( 4.4A)
 1.10A 1rjdB-3kvyA:
undetectable		 1rjdB-3kvyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 ARG A 137
TYR A 213
ASP A 220
GLU A 247
 SO4  A 311 ( 3.0A)
None
None
R2B  A 313 ( 4.4A)
 1.11A 1rjdC-3kvyA:
undetectable		 1rjdC-3kvyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.26A 1rxcB-3kvyA:
27.1		 1rxcB-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 7 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.41A 1rxcC-3kvyA:
25.9		 1rxcC-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 7 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.29A 1rxcD-3kvyA:
26.9		 1rxcD-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.30A 1rxcE-3kvyA:
27.2		 1rxcE-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 7 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.26A 1rxcF-3kvyA:
27.3		 1rxcF-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.26A 1rxcI-3kvyA:
27.3		 1rxcI-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.30A 1rxcK-3kvyA:
25.6		 1rxcK-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 7 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.23A 1rxcL-3kvyA:
27.2		 1rxcL-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.37A 1vhwA-3kvyA:
25.4
1vhwD-3kvyA:
25.5		 1vhwA-3kvyA:
26.75
1vhwD-3kvyA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 9 MET A 109
ARG A 137
GLY A 142
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.35A 1vhwB-3kvyA:
25.3
1vhwF-3kvyA:
24.9		 1vhwB-3kvyA:
26.75
1vhwF-3kvyA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.37A 1vhwC-3kvyA:
25.5
1vhwE-3kvyA:
25.3		 1vhwC-3kvyA:
26.75
1vhwE-3kvyA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.37A 1vhwA-3kvyA:
25.4
1vhwD-3kvyA:
25.5		 1vhwA-3kvyA:
26.75
1vhwD-3kvyA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.38A 1vhwC-3kvyA:
25.5
1vhwE-3kvyA:
25.3		 1vhwC-3kvyA:
26.75
1vhwE-3kvyA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 10 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.38A 1vhwB-3kvyA:
25.3
1vhwF-3kvyA:
24.9		 1vhwB-3kvyA:
26.75
1vhwF-3kvyA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		8 / 10 MET A 109
ARG A 137
THR A 140
GLY A 142
THR A 209
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
None
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.59A 1z35A-3kvyA:
23.9		 1z35A-3kvyA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 9 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.49A 1z37A-3kvyA:
23.8		 1z37A-3kvyA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.35A 2ac7A-3kvyA:
23.5
2ac7B-3kvyA:
23.6		 2ac7A-3kvyA:
25.24
2ac7B-3kvyA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 2ac7A-3kvyA:
23.5
2ac7B-3kvyA:
23.6		 2ac7A-3kvyA:
25.24
2ac7B-3kvyA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 12 PHE A 301
VAL A 133
VAL A  57
LEU A 118
LEU A 124
 None
 1.39A 2hc4A-3kvyA:
undetectable		 2hc4A-3kvyA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		10 / 10 THR A 140
GLY A 142
PHE A 212
GLN A 216
ARG A 218
GLU A 247
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-4.5A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
None
None
None
 0.18A 3kvrA-3kvyA:
49.5		 3kvrA-3kvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		10 / 10 THR A 140
GLY A 142
PHE A 212
GLN A 216
ARG A 218
GLU A 247
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-4.5A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
None
None
None
 0.26A 3kvrB-3kvyA:
8.3		 3kvrB-3kvyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.25A 3kvvA-3kvyA:
26.0		 3kvvA-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.26A 3kvvB-3kvyA:
25.8		 3kvvB-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.27A 3kvvC-3kvyA:
25.4		 3kvvC-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.32A 3kvvD-3kvyA:
25.2		 3kvvD-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.28A 3kvvE-3kvyA:
26.3		 3kvvE-3kvyA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.29A 3kvvF-3kvyA:
25.1		 3kvvF-3kvyA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		9 / 9 THR A 140
GLY A 142
GLN A 216
ARG A 218
GLU A 247
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
None
None
None
 0.15A 3nbqA-3kvyA:
46.7		 3nbqA-3kvyA:
75.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		8 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
None
None
 0.21A 3nbqB-3kvyA:
46.4		 3nbqB-3kvyA:
75.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		8 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
None
None
 0.16A 3nbqC-3kvyA:
46.5		 3nbqC-3kvyA:
75.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		9 / 9 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
LEU A 271
LEU A 272
ARG A 274
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
None
None
None
 0.23A 3nbqD-3kvyA:
46.5		 3nbqD-3kvyA:
75.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 9 ASP A 278
GLY A 277
ILE A 280
GLY A 143
ILE A 144
 None
 0.96A 3ogpA-3kvyA:
undetectable		 3ogpA-3kvyA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 LEU A 196
GLU A 198
SER A 193
THR A 201
 None
 1.49A 3ropA-3kvyA:
2.2		 3ropA-3kvyA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_A_ADNA251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 9 MET A 109
ARG A 137
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.46A 3u40A-3kvyA:
24.3
3u40F-3kvyA:
23.3		 3u40A-3kvyA:
27.36
3u40F-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 MET A 109
ARG A 137
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.44A 3u40B-3kvyA:
24.4
3u40C-3kvyA:
24.0		 3u40B-3kvyA:
27.36
3u40C-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 12 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 3u40B-3kvyA:
24.5
3u40C-3kvyA:
24.0		 3u40B-3kvyA:
27.36
3u40C-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.33A 3u40D-3kvyA:
24.6
3u40E-3kvyA:
23.7		 3u40D-3kvyA:
27.36
3u40E-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 12 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.37A 3u40D-3kvyA:
24.6
3u40E-3kvyA:
23.7		 3u40D-3kvyA:
27.36
3u40E-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 MET A 109
ARG A 137
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.39A 3u40A-3kvyA:
24.3
3u40F-3kvyA:
23.3		 3u40A-3kvyA:
27.36
3u40F-3kvyA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 11 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.36A 3uawA-3kvyA:
24.4		 3uawA-3kvyA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		7 / 10 MET A 109
ARG A 137
THR A 140
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 3uayA-3kvyA:
24.9		 3uayA-3kvyA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.32A 4d9hA-3kvyA:
25.0		 4d9hA-3kvyA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 10 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.35A 4da7A-3kvyA:
25.0		 4da7A-3kvyA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 11 MET A 109
ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.30A 4danA-3kvyA:
24.6		 4danA-3kvyA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 12 ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.32A 4danA-3kvyA:
24.6
4danB-3kvyA:
24.5		 4danA-3kvyA:
25.08
4danB-3kvyA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.28A 4e1vA-3kvyA:
25.9		 4e1vA-3kvyA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 7 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.33A 4e1vB-3kvyA:
25.7		 4e1vB-3kvyA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.29A 4e1vC-3kvyA:
25.4		 4e1vC-3kvyA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.30A 4e1vD-3kvyA:
25.7		 4e1vD-3kvyA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.30A 4e1vE-3kvyA:
26.2		 4e1vE-3kvyA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 6 GLY A 142
GLN A 216
ARG A 218
MET A 248
 URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.29A 4e1vF-3kvyA:
25.7		 4e1vF-3kvyA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.49A 4e1vG-3kvyA:
25.4		 4e1vG-3kvyA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
 0.30A 4e1vH-3kvyA:
25.7		 4e1vH-3kvyA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 7 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
 0.33A 4txnA-3kvyA:
41.6		 4txnA-3kvyA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 7 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
 0.36A 4txnB-3kvyA:
41.8		 4txnB-3kvyA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 7 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
 0.32A 4txnC-3kvyA:
41.8		 4txnC-3kvyA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		6 / 7 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
 0.36A 4txnD-3kvyA:
41.7		 4txnD-3kvyA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 9 MET A 109
ARG A 137
GLY A 142
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 5i3cA-3kvyA:
25.1		 5i3cA-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 MET A 109
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 5i3cB-3kvyA:
14.4		 5i3cB-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 11 MET A 109
GLY A 142
GLU A 247
MET A 248
GLU A 249
 R2B  A 313 (-3.9A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.34A 5i3cC-3kvyA:
25.3		 5i3cC-3kvyA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		5 / 10 LEU A 118
ALA A 250
GLY A 139
ILE A 138
ILE A 114
 None
None
SO4  A 311 (-3.5A)
None
None
 1.03A 5kr1A-3kvyA:
undetectable		 5kr1A-3kvyA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		3 / 3 ALA A 250
GLN A 156
THR A 154
 None
 0.76A 5n0oA-3kvyA:
undetectable		 5n0oA-3kvyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 3kvy URIDINE
PHOSPHORYLASE
(Bos
taurus) 		4 / 5 THR A 140
THR A 209
GLN A 216
ASP A 159
 SO4  A 311 ( 3.1A)
None
URA  A 312 (-3.3A)
None
 1.38A 6ectA-3kvyA:
undetectable		 6ectA-3kvyA:
22.64