SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 7 SER A 382
ASP A 383
GLU A 375
GLU A 309
 None
 1.04A 1knyA-3kwlA:
undetectable
1knyB-3kwlA:
undetectable		 1knyA-3kwlA:
18.08
1knyB-3kwlA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 9 SER A 290
ALA A 318
HIS A 317
VAL A 332
VAL A 321
 None
 1.25A 1td2B-3kwlA:
undetectable		 1td2B-3kwlA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 9 SER A 290
ALA A 318
THR A 283
VAL A 332
VAL A 321
 None
 1.39A 1td2B-3kwlA:
undetectable		 1td2B-3kwlA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		3 / 3 ASP A 141
ASP A 190
ASN A 174
 None
 0.65A 2bm9D-3kwlA:
undetectable		 2bm9D-3kwlA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 6 LEU A 245
ALA A 404
ASP A 273
TYR A 272
 None
 1.15A 2dpzA-3kwlA:
undetectable		 2dpzA-3kwlA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		3 / 3 LEU A 268
PRO A 269
LEU A 296
 None
 0.49A 2qd5B-3kwlA:
2.4		 2qd5B-3kwlA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QPU_B_QPSB3000_1
(ALPHA-AMYLASE TYPE A
ISOZYME)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 9 TYR A 442
ASP A 246
VAL A 247
ASP A 310
ALA A 242
 None
 1.32A 2qpuB-3kwlA:
1.0		 2qpuB-3kwlA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 6 PHE A 211
ILE A 281
GLY A 275
GLY A 274
 None
 0.82A 2qx6A-3kwlA:
undetectable
2qx6B-3kwlA:
undetectable		 2qx6A-3kwlA:
19.10
2qx6B-3kwlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_A_FOLA270_0
(PTERIDINE REDUCTASE)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 11 PHE A 143
PHE A 106
TYR A 103
VAL A 172
MET A 151
 None
 1.39A 3bmcA-3kwlA:
2.1		 3bmcA-3kwlA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_D_FOLD270_0
(PTERIDINE REDUCTASE)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 12 PHE A 143
PHE A 106
TYR A 103
VAL A 172
MET A 151
 None
 1.35A 3bmcD-3kwlA:
1.8		 3bmcD-3kwlA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 9 ILE A 113
LEU A 121
PHE A 124
LEU A 162
GLY A 142
 None
 1.47A 3nxuB-3kwlA:
undetectable		 3nxuB-3kwlA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 12 VAL A 172
TYR A 194
ILE A 205
ILE A 280
TYR A 277
 None
 1.30A 3q5pA-3kwlA:
undetectable		 3q5pA-3kwlA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 6 LEU A 483
SER A 253
ALA A 254
LEU A 485
 None
 1.05A 3ravA-3kwlA:
undetectable		 3ravA-3kwlA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 6 LEU A 483
SER A 253
ALA A 254
LEU A 485
 None
 1.04A 3rd0A-3kwlA:
undetectable		 3rd0A-3kwlA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 8 ALA A 404
PHE A 466
ASN A 402
THR A 464
 None
 0.91A 3t3sF-3kwlA:
undetectable		 3t3sF-3kwlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 6 PHE A 466
LEU A 465
PRO A 468
SER A 253
 None
 1.40A 3vlnA-3kwlA:
undetectable		 3vlnA-3kwlA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 6 TYR A 276
ARG A 378
ASP A 273
LEU A 313
 None
 1.41A 4ax8A-3kwlA:
undetectable		 4ax8A-3kwlA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		3 / 3 TYR A 423
HIS A 490
ARG A 422
 None
 1.00A 4htfA-3kwlA:
undetectable		 4htfA-3kwlA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 4 HIS A 384
GLU A 375
HIS A 436
LEU A 352
 None
 1.43A 4m2rA-3kwlA:
undetectable		 4m2rA-3kwlA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 7 LEU A 294
ILE A 328
ILE A 329
VAL A 332
 None
 0.84A 4ojbA-3kwlA:
undetectable		 4ojbA-3kwlA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 12 ALA A 311
TYR A 351
LEU A 250
GLU A 309
ASN A 402
 None
 1.26A 4pb1A-3kwlA:
undetectable		 4pb1A-3kwlA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 12 ALA A 311
TYR A 351
LEU A 250
GLU A 309
ASN A 402
 None
 1.25A 4pd9A-3kwlA:
undetectable		 4pd9A-3kwlA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 4 SER A 437
ALA A 435
GLN A 469
THR A 464
 None
 1.48A 5n0rA-3kwlA:
undetectable		 5n0rA-3kwlA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 4 SER A 437
ALA A 435
GLN A 469
THR A 464
 None
 1.46A 5n0sA-3kwlA:
undetectable		 5n0sA-3kwlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		4 / 4 SER A 437
ALA A 435
GLN A 469
THR A 464
 None
 1.47A 5n0wA-3kwlA:
undetectable		 5n0wA-3kwlA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		5 / 12 LEU A 139
GLY A 140
ASN A 102
GLU A 104
LEU A 100
 None
 1.24A 5nwvA-3kwlA:
undetectable		 5nwvA-3kwlA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3kwl UNCHARACTERIZED
PROTEIN
(Helicobacter
pylori) 		3 / 3 LYS A 478
LYS A 365
SER A 366
 None
 1.23A 5odiA-3kwlA:
undetectable		 5odiA-3kwlA:
21.98