SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kwp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 5 LEU A 167
SER A 133
LEU A 130
GLY A 232
None
1.05A 1a4lC-3kwpA:
undetectable
1a4lC-3kwpA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 GLY A  23
ALA A 123
THR A 200
ILE A  22
None
0.79A 1gtnA-3kwpA:
undetectable
1gtnK-3kwpA:
undetectable
1gtnA-3kwpA:
15.00
1gtnK-3kwpA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 8 GLY A  23
ALA A 123
THR A 200
ILE A  22
None
0.83A 1gtnE-3kwpA:
undetectable
1gtnF-3kwpA:
undetectable
1gtnE-3kwpA:
15.00
1gtnF-3kwpA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 8 GLY A  23
ALA A 123
THR A 200
ILE A  22
None
0.83A 1gtnP-3kwpA:
undetectable
1gtnQ-3kwpA:
undetectable
1gtnP-3kwpA:
15.00
1gtnQ-3kwpA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 6 THR A 179
PHE A 169
PHE A 187
GLU A 156
None
1.15A 1icuC-3kwpA:
undetectable
1icuD-3kwpA:
undetectable
1icuC-3kwpA:
23.13
1icuD-3kwpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 8 GLY A  23
ALA A 123
THR A 200
ILE A  22
None
0.79A 1utdI-3kwpA:
undetectable
1utdJ-3kwpA:
undetectable
1utdI-3kwpA:
15.00
1utdJ-3kwpA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 8 GLY A  23
ALA A 123
THR A 200
ILE A  22
None
0.81A 1utdJ-3kwpA:
undetectable
1utdK-3kwpA:
undetectable
1utdJ-3kwpA:
15.00
1utdK-3kwpA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 8 LYS A 177
LEU A 180
GLN A 181
LEU A 195
None
0.90A 1v54P-3kwpA:
undetectable
1v54W-3kwpA:
undetectable
1v54P-3kwpA:
20.92
1v54W-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 LYS A 177
LEU A 180
GLN A 181
LEU A 195
None
0.96A 1v55P-3kwpA:
undetectable
1v55W-3kwpA:
undetectable
1v55P-3kwpA:
20.92
1v55W-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
3 / 3 MET A  28
ASN A  49
GLN A  63
None
1.04A 1xoqB-3kwpA:
undetectable
1xoqB-3kwpA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 8 LYS A 177
LEU A 180
GLN A 181
LEU A 195
None
0.90A 2dyrP-3kwpA:
undetectable
2dyrW-3kwpA:
undetectable
2dyrP-3kwpA:
20.92
2dyrW-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 LEU A 180
GLN A 181
LEU A 195
PHE A 227
None
1.02A 2dysC-3kwpA:
undetectable
2dysJ-3kwpA:
undetectable
2dysC-3kwpA:
20.92
2dysJ-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 LYS A 177
LEU A 180
GLN A 181
LEU A 195
None
0.95A 2dysC-3kwpA:
undetectable
2dysJ-3kwpA:
undetectable
2dysC-3kwpA:
20.92
2dysJ-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 LYS A 177
LEU A 180
GLN A 181
LEU A 195
None
0.86A 2dysP-3kwpA:
undetectable
2dysW-3kwpA:
undetectable
2dysP-3kwpA:
20.92
2dysW-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 LYS A 177
LEU A 180
GLN A 181
LEU A 195
None
0.93A 2eijC-3kwpA:
undetectable
2eijJ-3kwpA:
undetectable
2eijC-3kwpA:
20.92
2eijJ-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 LYS A 177
LEU A 180
GLN A 181
LEU A 195
None
0.91A 2eijP-3kwpA:
undetectable
2eijW-3kwpA:
undetectable
2eijP-3kwpA:
20.92
2eijW-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 8 LYS A 177
LEU A 180
GLN A 181
LEU A 195
None
0.92A 2eikP-3kwpA:
undetectable
2eikW-3kwpA:
undetectable
2eikP-3kwpA:
20.92
2eikW-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 LYS A 177
LEU A 180
GLN A 181
LEU A 195
None
0.86A 2eimC-3kwpA:
undetectable
2eimJ-3kwpA:
undetectable
2eimC-3kwpA:
20.92
2eimJ-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 LEU A 180
GLN A 181
LEU A 195
PHE A 227
None
0.94A 2zxwC-3kwpA:
undetectable
2zxwJ-3kwpA:
undetectable
2zxwC-3kwpA:
20.92
2zxwJ-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 LYS A 177
LEU A 180
GLN A 181
LEU A 195
None
0.90A 2zxwC-3kwpA:
undetectable
2zxwJ-3kwpA:
undetectable
2zxwC-3kwpA:
20.92
2zxwJ-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 6 LEU A 180
GLN A 181
LEU A 195
PHE A 227
None
0.97A 3ag1C-3kwpA:
undetectable
3ag1J-3kwpA:
undetectable
3ag1C-3kwpA:
20.92
3ag1J-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
5 / 12 ILE A 111
ALA A 113
LEU A  82
LEU A 106
LEU A  17
None
1.16A 3ix9B-3kwpA:
5.5
3ix9B-3kwpA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 6 LEU A 160
LEU A 167
GLU A 165
TYR A 141
None
0.99A 4f3tA-3kwpA:
undetectable
4f3tA-3kwpA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
3 / 3 GLN A  51
THR A  50
THR A  47
None
0.82A 4fu9A-3kwpA:
undetectable
4fu9A-3kwpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
3 / 3 GLN A  51
THR A  50
THR A  47
None
0.80A 4fufA-3kwpA:
undetectable
4fufA-3kwpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 GLU A 205
LEU A 195
LEU A 176
LEU A 180
None
0.77A 4wg0B-3kwpA:
undetectable
4wg0C-3kwpA:
undetectable
4wg0B-3kwpA:
6.41
4wg0C-3kwpA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
4 / 7 LEU A 176
LEU A 180
GLU A 205
LEU A 195
None
0.79A 4wg0L-3kwpA:
undetectable
4wg0M-3kwpA:
undetectable
4wg0L-3kwpA:
6.41
4wg0M-3kwpA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
3 / 3 LYS A 178
ARG A 175
HIS A 174
None
0.80A 4zbrA-3kwpA:
undetectable
4zbrA-3kwpA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
5 / 12 ILE A  22
GLY A  95
ALA A 125
LEU A 199
GLU A 226
None
0.83A 5hw4A-3kwpA:
28.8
5hw4A-3kwpA:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
8 / 12 ILE A  22
GLY A  95
ALA A 125
PHE A 145
TYR A 170
LEU A 199
LYS A 201
VAL A 228
None
0.54A 5hw4A-3kwpA:
28.8
5hw4A-3kwpA:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
5 / 11 ILE A  22
GLY A  95
ALA A 125
LEU A 199
GLU A 226
None
0.86A 5hw4B-3kwpA:
28.9
5hw4B-3kwpA:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
8 / 11 ILE A  22
GLY A  95
ALA A 125
PHE A 145
TYR A 170
LEU A 199
LYS A 201
VAL A 228
None
0.53A 5hw4B-3kwpA:
28.9
5hw4B-3kwpA:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
5 / 12 ILE A  22
GLY A  95
ALA A 125
LEU A 199
GLU A 226
None
0.86A 5hw4C-3kwpA:
29.0
5hw4C-3kwpA:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis)
8 / 12 ILE A  22
GLY A  95
ALA A 125
PHE A 145
TYR A 170
LEU A 199
LYS A 201
VAL A 228
None
0.55A 5hw4C-3kwpA:
29.0
5hw4C-3kwpA:
42.42