SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kwu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 3kwu MUNC13-1
(Rattus
norvegicus) 		4 / 4 LYS A 704
LEU A 778
ALA A 703
LEU A 701
 CL  A 911 ( 3.2A)
None
None
None
 1.41A 1f86B-3kwuA:
2.7		 1f86B-3kwuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3kwu MUNC13-1
(Rattus
norvegicus) 		4 / 8 THR A 781
LEU A 788
VAL A 716
VAL A 753
 None
 0.87A 1t86A-3kwuA:
undetectable		 1t86A-3kwuA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 3kwu MUNC13-1
(Rattus
norvegicus) 		4 / 4 LYS A 704
LEU A 778
ALA A 703
LEU A 701
 CL  A 911 ( 3.2A)
None
None
None
 1.47A 2roxA-3kwuA:
2.5		 2roxA-3kwuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3kwu MUNC13-1
(Rattus
norvegicus) 		4 / 7 GLY A 779
VAL A 807
ILE A 811
VAL A 753
 None
 0.90A 3fi0E-3kwuA:
undetectable		 3fi0E-3kwuA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3kwu MUNC13-1
(Rattus
norvegicus) 		5 / 9 GLN A 780
ARG A 801
GLY A 779
VAL A 807
SER A 805
 None
None
None
None
CL  A 911 (-4.4A)
 1.23A 4a3uA-3kwuA:
undetectable		 4a3uA-3kwuA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3kwu MUNC13-1
(Rattus
norvegicus) 		5 / 7 GLN A 780
ARG A 801
GLY A 779
VAL A 807
SER A 805
 None
None
None
None
CL  A 911 (-4.4A)
 1.23A 4a3uB-3kwuA:
undetectable		 4a3uB-3kwuA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3kwu MUNC13-1
(Rattus
norvegicus) 		4 / 7 THR A 781
LEU A 788
VAL A 716
VAL A 753
 None
 0.93A 4cp4A-3kwuA:
undetectable		 4cp4A-3kwuA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3kwu MUNC13-1
(Rattus
norvegicus) 		4 / 8 THR A 781
LEU A 798
VAL A 755
VAL A 753
 None
 0.77A 4em2A-3kwuA:
undetectable		 4em2A-3kwuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3kwu MUNC13-1
(Rattus
norvegicus) 		4 / 6 ALA A 689
VAL A 817
VAL A 718
HIS A 745
 None
 0.95A 5eckA-3kwuA:
undetectable		 5eckA-3kwuA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3kwu MUNC13-1
(Rattus
norvegicus) 		4 / 6 ALA A 689
VAL A 817
VAL A 718
HIS A 745
 None
 0.91A 5eckD-3kwuA:
undetectable		 5eckD-3kwuA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3kwu MUNC13-1
(Rattus
norvegicus) 		4 / 6 ALA A 689
VAL A 817
VAL A 718
HIS A 745
 None
 0.96A 5eclA-3kwuA:
undetectable		 5eclA-3kwuA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3kwu MUNC13-1
(Rattus
norvegicus) 		3 / 3 ILE A 728
THR A 727
PRO A 734
 None
 0.62A 6ncsA-3kwuA:
undetectable		 6ncsA-3kwuA:
20.07