SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		3 / 3 TYR B 440
ARG B 427
GLN B 423
 None
 1.02A 1tw4A-3kx2B:
undetectable		 1tw4A-3kx2B:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 8 PHE B 480
ARG B 237
ALA B 200
LEU B 227
 None
 1.05A 1x8vA-3kx2B:
undetectable		 1x8vA-3kx2B:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 619
ALA B 616
LEU B 530
ILE B 542
PHE B 178
 None
 1.40A 1y0xX-3kx2B:
undetectable		 1y0xX-3kx2B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 197
ARG B 198
LEU B 472
HIS B 204
LEU B 469
 None
 1.31A 2bxeA-3kx2B:
2.1		 2bxeA-3kx2B:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 193
ASP B 225
ASP B 215
 None
None
MG  B 800 ( 4.0A)
 0.76A 2igtA-3kx2B:
4.8		 2igtA-3kx2B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 193
ASP B 225
ASP B 215
 None
None
MG  B 800 ( 4.0A)
 0.76A 2igtB-3kx2B:
4.8		 2igtB-3kx2B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 608
ALA B 568
ILE B 571
ASP B 605
LEU B 613
 None
 1.12A 2jn3A-3kx2B:
undetectable		 2jn3A-3kx2B:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		3 / 3 ARG B 620
SER B 621
TYR B 586
 None
 0.89A 2q2hA-3kx2B:
undetectable
2q2hB-3kx2B:
undetectable		 2q2hA-3kx2B:
11.62
2q2hB-3kx2B:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 214
LEU B 227
ILE B 212
PHE B 259
LEU B 241
 None
 1.20A 2qeiA-3kx2B:
undetectable		 2qeiA-3kx2B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		5 / 11 THR B 376
ILE B 316
GLY B 312
GLY B 346
PRO B 343
 None
 1.36A 2y7kA-3kx2B:
undetectable		 2y7kA-3kx2B:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		5 / 10 THR B 376
ILE B 316
GLY B 312
GLY B 346
PRO B 343
 None
 1.38A 2y7pA-3kx2B:
undetectable		 2y7pA-3kx2B:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 5 ARG B  55
PHE B 132
PHE B  50
LEU B 138
 None
 1.33A 3ag3C-3kx2B:
undetectable
3ag3J-3kx2B:
undetectable		 3ag3C-3kx2B:
15.22
3ag3J-3kx2B:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 5 ARG B 159
ILE B  86
TYR B  83
THR B  80
 ADP  B1000 (-3.6A)
None
None
None
 1.32A 3dgqA-3kx2B:
undetectable		 3dgqA-3kx2B:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		5 / 9 VAL B 713
ALA B 691
ILE B 681
PHE B 699
ILE B 695
 None
 1.16A 3hbbB-3kx2B:
undetectable		 3hbbB-3kx2B:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 310
ILE B 416
GLY B 395
PRO B 394
TYR B 286
 None
 1.38A 3hgiA-3kx2B:
undetectable		 3hgiA-3kx2B:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		3 / 3 PRO B 263
LEU B 264
GLN B 256
 None
 0.71A 3hznG-3kx2B:
undetectable
3hznH-3kx2B:
undetectable		 3hznG-3kx2B:
15.01
3hznH-3kx2B:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		3 / 3 ARG B 427
VAL B 156
THR B 123
 None
None
MG  B 800 ( 3.0A)
 0.81A 3ndtA-3kx2B:
undetectable		 3ndtA-3kx2B:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 5 ILE B  19
GLN B  22
ILE B  26
GLU B 633
 None
 1.01A 4a99D-3kx2B:
undetectable		 4a99D-3kx2B:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		3 / 3 PHE B 657
VAL B 546
ILE B 542
 None
 0.62A 4emaA-3kx2B:
undetectable		 4emaA-3kx2B:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 222
PHE B 480
LEU B 469
GLY B 229
LEU B 197
 None
 1.10A 4zbrA-3kx2B:
undetectable		 4zbrA-3kx2B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 8 MET B 201
LEU B 472
LEU B 477
LEU B 467
 None
 1.18A 5dxeA-3kx2B:
undetectable		 5dxeA-3kx2B:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		3 / 3 SER B 247
LEU B 105
MET B 112
 None
 0.83A 5ikrB-3kx2B:
undetectable		 5ikrB-3kx2B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 7 GLY B 269
GLY B 116
PHE B 114
LEU B 265
 None
 0.84A 5izfA-3kx2B:
undetectable		 5izfA-3kx2B:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 8 ALA B 157
VAL B 160
ILE B 213
VAL B 143
 None
 0.49A 5nujA-3kx2B:
undetectable		 5nujA-3kx2B:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 103
VAL B 130
LEU B 265
ILE B 244
 None
 0.89A 5v0vA-3kx2B:
undetectable		 5v0vA-3kx2B:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 5 ARG B  55
PHE B 132
PHE B  50
LEU B 138
 None
 1.34A 5wauC-3kx2B:
undetectable
5wauJ-3kx2B:
undetectable		 5wauC-3kx2B:
15.22
5wauJ-3kx2B:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		3 / 3 THR B 636
GLU B 541
HIS B 587
 None
 0.78A 5xioA-3kx2B:
undetectable		 5xioA-3kx2B:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		3 / 3 THR B 636
GLU B 541
HIS B 587
 None
 0.83A 5xiqB-3kx2B:
undetectable		 5xiqB-3kx2B:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		3 / 3 THR B 636
GLU B 541
HIS B 587
 None
 0.76A 5xiqD-3kx2B:
undetectable		 5xiqD-3kx2B:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 8 MET B 201
LEU B 472
LEU B 477
LEU B 467
 None
 1.19A 6cbzA-3kx2B:
undetectable		 6cbzA-3kx2B:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 7 ASP B 505
ALA B 502
GLU B  25
LEU B 510
 None
 1.07A 6ci6A-3kx2B:
undetectable		 6ci6A-3kx2B:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		5 / 10 SER B 518
LEU B 477
LEU B 498
ILE B 474
GLY B 473
 None
 1.11A 6dm0B-3kx2B:
2.3
6dm0C-3kx2B:
2.3		 6dm0B-3kx2B:
7.65
6dm0C-3kx2B:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43
(Saccharomyces
cerevisiae) 		4 / 5 ILE B 176
GLN B 147
THR B 192
LEU B 168
 None
MG  B 800 ( 4.8A)
None
None
 1.12A 6f3mD-3kx2B:
undetectable		 6f3mD-3kx2B:
21.99