SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 4 THR A 204
LEU A 208
VAL A 211
LEU A 215
 None
 0.49A 1fbmB-3kx6A:
undetectable		 1fbmB-3kx6A:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 4 THR A 204
LEU A 208
VAL A 211
LEU A 215
 None
 0.63A 1fbmD-3kx6A:
undetectable		 1fbmD-3kx6A:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 5 THR A 204
LEU A 208
VAL A 211
LEU A 215
 None
 0.51A 1fbmE-3kx6A:
undetectable		 1fbmE-3kx6A:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 4 THR A 204
LEU A 208
VAL A 211
LEU A 215
 None
 0.67A 1mz9D-3kx6A:
undetectable		 1mz9D-3kx6A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 7 PHE A  61
ALA A  30
ILE A  37
GLU A  32
 None
 0.83A 1oniA-3kx6A:
undetectable
1oniB-3kx6A:
undetectable		 1oniA-3kx6A:
20.11
1oniB-3kx6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 7 PHE A  61
ALA A  30
ILE A  37
GLU A  32
 None
 0.79A 1oniD-3kx6A:
1.5
1oniF-3kx6A:
undetectable		 1oniD-3kx6A:
20.11
1oniF-3kx6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 7 ILE A  37
GLU A  32
PHE A  61
ALA A  30
 None
 1.00A 1oniD-3kx6A:
undetectable
1oniE-3kx6A:
undetectable		 1oniD-3kx6A:
20.11
1oniE-3kx6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 7 ILE A  37
GLU A  32
PHE A  61
ALA A  30
 None
 0.92A 1oniG-3kx6A:
undetectable
1oniI-3kx6A:
undetectable		 1oniG-3kx6A:
20.11
1oniI-3kx6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 5 TRP A 293
PRO A 260
LEU A 222
GLY A 224
 None
 1.44A 1ya4C-3kx6A:
undetectable		 1ya4C-3kx6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		5 / 8 VAL A 105
ASP A  31
THR A 122
TYR A 172
LEU A 127
 None
 1.29A 1z2bB-3kx6A:
undetectable		 1z2bB-3kx6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		5 / 12 GLY A 224
GLN A 177
VAL A 182
LEU A 215
ILE A  20
 None
 1.27A 3h52B-3kx6A:
undetectable		 3h52B-3kx6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		5 / 10 ILE A  70
SER A 296
LYS A  25
GLY A  26
LEU A  66
 None
 1.42A 3ik6B-3kx6A:
undetectable
3ik6E-3kx6A:
undetectable		 3ik6B-3kx6A:
23.70
3ik6E-3kx6A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 4 GLY A  67
GLY A  65
THR A  63
LEU A 325
 None
 0.87A 3si7C-3kx6A:
undetectable
3si7D-3kx6A:
undetectable		 3si7C-3kx6A:
21.17
3si7D-3kx6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 6 ARG A 257
TYR A 356
PHE A 249
LEU A 250
 None
 1.34A 3tgvB-3kx6A:
undetectable		 3tgvB-3kx6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 5 ARG A 257
TYR A 356
PHE A 249
LEU A 250
 None
 1.35A 3tgvC-3kx6A:
undetectable		 3tgvC-3kx6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 8 THR A 168
LEU A 127
LEU A 124
GLY A 123
 None
 0.70A 4c9nA-3kx6A:
undetectable		 4c9nA-3kx6A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		5 / 12 LEU A 221
GLU A  15
ALA A  17
VAL A 182
GLY A 180
 PEG  A 401 ( 4.6A)
None
None
None
None
 1.05A 4hfpD-3kx6A:
undetectable		 4hfpD-3kx6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		5 / 12 PHE A  61
VAL A  91
PRO A 101
SER A 298
GLY A  26
 None
None
None
CIT  A 400 (-4.9A)
None
 1.41A 4hvcA-3kx6A:
undetectable		 4hvcA-3kx6A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 7 THR A 258
LEU A 148
ASN A 230
LEU A 269
 None
None
None
CIT  A 400 (-4.0A)
 1.06A 4ib4A-3kx6A:
undetectable		 4ib4A-3kx6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		5 / 12 PHE A  61
VAL A  91
PRO A 101
SER A 298
GLY A  26
 None
None
None
CIT  A 400 (-4.9A)
None
 1.50A 4olfA-3kx6A:
undetectable		 4olfA-3kx6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 6 LEU A 282
LEU A 269
THR A 233
VAL A 247
 None
CIT  A 400 (-4.0A)
None
None
 1.08A 4udaA-3kx6A:
undetectable		 4udaA-3kx6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 8 ASN A 230
PRO A 229
PHE A 268
SER A 270
 None
None
None
CIT  A 400 (-3.4A)
 1.37A 5amiB-3kx6A:
undetectable		 5amiB-3kx6A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		5 / 12 LEU A  80
VAL A  91
PRO A 101
SER A 298
GLY A  26
 None
None
None
CIT  A 400 (-4.9A)
None
 1.35A 5f9zB-3kx6A:
undetectable		 5f9zB-3kx6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		5 / 12 PHE A 212
VAL A 211
PRO A 187
PHE A 268
GLY A 271
 None
None
None
None
CIT  A 400 (-3.4A)
 1.33A 5f9zB-3kx6A:
undetectable		 5f9zB-3kx6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		4 / 4 LEU A   5
LEU A  13
GLY A 224
GLU A 223
 None
 1.16A 5hhjA-3kx6A:
undetectable		 5hhjA-3kx6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		5 / 12 GLY A 138
TYR A 135
SER A  18
ILE A  20
PHE A  19
 None
 1.26A 5igwA-3kx6A:
0.6		 5igwA-3kx6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		5 / 9 VAL A 105
ASP A  31
THR A 122
TYR A 172
LEU A 127
 None
 1.31A 5j2tB-3kx6A:
0.0		 5j2tB-3kx6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Babesia
bovis) 		5 / 12 VAL A 232
ARG A 301
ILE A  74
LEU A  28
GLY A  26
 None
CIT  A 400 (-3.5A)
None
None
None
 1.08A 6c2mA-3kx6A:
undetectable		 6c2mA-3kx6A:
12.13