SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 CYH A 121
LEU A 142
ILE A 207
ILE A 182
VAL A 183
 None
 1.23A 1pkvA-3kxdA:
undetectable
1pkvB-3kxdA:
undetectable		 1pkvA-3kxdA:
14.16
1pkvB-3kxdA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 ILE A 321
GLY A 290
THR A 289
GLU A 326
GLY A 322
 None
CD  A 604 (-4.5A)
None
CD  A 604 (-2.5A)
CD  A 604 ( 4.3A)
 1.27A 2fn1B-3kxdA:
undetectable		 2fn1B-3kxdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 185
GLU A 190
LEU A 170
LEU A 142
GLY A 162
 None
 1.36A 3g1uA-3kxdA:
7.9		 3g1uA-3kxdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 185
GLU A 190
LEU A 170
LEU A 142
GLY A 162
 None
 1.42A 3g1uC-3kxdA:
5.3		 3g1uC-3kxdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLY A 122
TRP A 123
VAL A 148
 None
 0.76A 3n62B-3kxdA:
undetectable		 3n62B-3kxdA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLY A 122
TRP A 123
VAL A 148
 None
 0.77A 3n65B-3kxdA:
undetectable		 3n65B-3kxdA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLY A 122
TRP A 123
VAL A 148
 None
 0.76A 3n66B-3kxdA:
undetectable		 3n66B-3kxdA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 LEU A 185
THR A 127
GLY A 162
PRO A 164
 None
 0.72A 3ny4A-3kxdA:
undetectable		 3ny4A-3kxdA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLY A 122
TRP A 123
VAL A 148
 None
 0.74A 5vuoB-3kxdA:
undetectable		 5vuoB-3kxdA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 GLY A 246
ASP A 245
ARG A 241
MET A 264
 None
 1.47A 5zrfB-3kxdA:
undetectable		 5zrfB-3kxdA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 144
ARG A 166
THR A 165
PRO A 164
 CD  A 603 (-3.7A)
None
None
None
 1.46A 6a4iB-3kxdA:
undetectable		 6a4iB-3kxdA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 122
ASP A 145
VAL A 148
ASP A 163
LEU A 185
 None
 1.08A 6bq4B-3kxdA:
5.8		 6bq4B-3kxdA:
18.31