SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		5 / 6 LEU A  84
ASP A  85
LEU A  66
ILE A 118
GLU A  82
 None
 1.49A 1mt1A-3kxiA:
undetectable
1mt1F-3kxiA:
undetectable		 1mt1A-3kxiA:
9.88
1mt1F-3kxiA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		5 / 12 LEU A  78
HIS A  70
ILE A  62
PHE A   7
ILE A  51
 None
 1.32A 1ot7B-3kxiA:
undetectable		 1ot7B-3kxiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		4 / 7 LYS A 321
ILE A 262
ILE A 333
ASP A 329
 None
None
SCN  A 366 (-3.5A)
None
 0.81A 1uwjA-3kxiA:
undetectable		 1uwjA-3kxiA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		5 / 9 PHE A 249
PHE A 236
VAL A 185
LEU A 261
LEU A 285
 None
 1.37A 1wrkA-3kxiA:
undetectable
1wrkB-3kxiA:
undetectable		 1wrkA-3kxiA:
14.50
1wrkB-3kxiA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		4 / 7 GLN A 243
TYR A 114
TYR A  42
ILE A  62
 None
 1.35A 2ph9A-3kxiA:
undetectable
2ph9B-3kxiA:
undetectable		 2ph9A-3kxiA:
19.10
2ph9B-3kxiA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		5 / 12 LEU A  89
ILE A  93
LEU A  90
VAL A   8
THR A 188
 None
None
None
None
GDP  A 500 (-4.7A)
 1.07A 2qo6A-3kxiA:
undetectable		 2qo6A-3kxiA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		5 / 12 ALA A 335
GLY A 191
LEU A 336
PHE A 196
SER A 198
 GDP  A 500 (-3.8A)
GDP  A 500 (-3.2A)
GDP  A 500 (-3.9A)
None
SCN  A 366 ( 4.0A)
 1.21A 3pfgA-3kxiA:
2.5		 3pfgA-3kxiA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		3 / 3 LYS A   2
ARG A 111
LEU A  84
 None
 1.25A 3v4tE-3kxiA:
undetectable		 3v4tE-3kxiA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		5 / 10 ILE A  17
PHE A  63
VAL A  27
GLU A  92
ILE A  61
 None
 1.09A 5lg3H-3kxiA:
undetectable		 5lg3H-3kxiA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		4 / 7 LEU A 274
SER A 320
ILE A 331
ASN A 300
 None
None
None
GDP  A 500 (-3.0A)
 0.98A 5n5dA-3kxiA:
2.6		 5n5dA-3kxiA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3kxi GTP-BINDING PROTEIN
(HFLX)
(Sulfolobus
solfataricus) 		5 / 10 LEU A 252
THR A 251
ILE A  93
ILE A 237
ILE A 240
 None
 1.12A 6ebpD-3kxiA:
undetectable		 6ebpD-3kxiA:
12.36