SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		4 / 6 PRO A  75
ASP A  83
ASN A  82
ASP A  86
 None
 1.17A 1hpkA-3kxpA:
undetectable		 1hpkA-3kxpA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		5 / 11 ARG A  16
LEU A  24
HIS A  39
LEU A 107
TYR A  79
 None
None
None
CL  A 279 (-4.4A)
None
 1.28A 2bxmA-3kxpA:
2.6		 2bxmA-3kxpA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		5 / 12 VAL A  26
ILE A  62
VAL A  64
LEU A  95
THR A  94
 None
 0.72A 3fw3A-3kxpA:
undetectable		 3fw3A-3kxpA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		5 / 12 VAL A  26
ILE A  62
VAL A  64
LEU A  95
THR A  94
 None
 0.72A 3fw3B-3kxpA:
undetectable		 3fw3B-3kxpA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		5 / 12 LEU A  24
ASP A  65
VAL A  64
GLY A  70
TYR A  84
 None
 1.32A 3hgiA-3kxpA:
undetectable		 3hgiA-3kxpA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		5 / 12 THR A 203
LEU A 107
GLY A  40
THR A  42
VAL A 147
 None
CL  A 279 (-4.4A)
CL  A 279 ( 4.1A)
None
None
 1.06A 4c9lB-3kxpA:
undetectable		 4c9lB-3kxpA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		4 / 7 THR A  94
LEU A  95
LEU A  91
THR A  23
 None
 0.93A 4z90A-3kxpA:
undetectable
4z90B-3kxpA:
undetectable
4z90C-3kxpA:
undetectable
4z90D-3kxpA:
undetectable
4z90E-3kxpA:
undetectable		 4z90A-3kxpA:
21.61
4z90B-3kxpA:
21.61
4z90C-3kxpA:
21.61
4z90D-3kxpA:
21.61
4z90E-3kxpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		4 / 5 ALA A 162
TYR A 163
HIS A 105
PRO A 169
 None
 1.36A 4ze2A-3kxpA:
undetectable		 4ze2A-3kxpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		4 / 6 VAL A 225
LEU A  51
ILE A 272
ALA A 271
 None
 0.49A 4zf8A-3kxpA:
undetectable		 4zf8A-3kxpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		4 / 6 SER A 106
HIS A 258
LEU A 143
LEU A 140
 CL  A 279 (-2.8A)
None
None
None
 1.33A 5dzke-3kxpA:
2.2
5dzks-3kxpA:
undetectable		 5dzke-3kxpA:
20.81
5dzks-3kxpA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		3 / 3 SER A 106
ALA A 128
VAL A 127
 CL  A 279 (-2.8A)
None
None
 0.59A 5eypA-3kxpA:
4.1		 5eypA-3kxpA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		4 / 7 HIS A  69
HIS A 105
ILE A  41
TYR A  84
 None
None
CL  A 279 (-3.7A)
None
 1.23A 5kkzC-3kxpA:
undetectable
5kkzE-3kxpA:
undetectable		 5kkzC-3kxpA:
22.29
5kkzE-3kxpA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		4 / 7 HIS A 105
ILE A  41
TYR A  84
HIS A  69
 None
CL  A 279 (-3.7A)
None
None
 1.23A 5kkzK-3kxpA:
undetectable
5kkzQ-3kxpA:
undetectable		 5kkzK-3kxpA:
23.06
5kkzQ-3kxpA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		4 / 7 HIS A  69
HIS A 105
ILE A  41
TYR A  84
 None
None
CL  A 279 (-3.7A)
None
 1.23A 5kkzM-3kxpA:
undetectable
5kkzO-3kxpA:
undetectable		 5kkzM-3kxpA:
22.29
5kkzO-3kxpA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A220_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		5 / 9 LEU A 211
VAL A 212
LEU A 248
TYR A 134
VAL A 233
 None
 1.28A 5mxbA-3kxpA:
undetectable		 5mxbA-3kxpA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		4 / 7 VAL A 222
ILE A 224
PRO A 133
ALA A 128
 None
 0.73A 5ospA-3kxpA:
undetectable		 5ospA-3kxpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		4 / 8 GLY A 104
SER A  45
ALA A  63
PHE A  37
 None
 0.83A 5xu8A-3kxpA:
undetectable		 5xu8A-3kxpA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		4 / 5 ALA A 198
SER A 196
GLY A  68
TYR A  79
 None
 0.83A 5yodB-3kxpA:
undetectable		 5yodB-3kxpA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE
(Mesorhizobium
loti) 		3 / 3 ASP A 277
PHE A  59
ARG A 124
 None
 0.96A 5yw0A-3kxpA:
undetectable		 5yw0A-3kxpA:
22.06