SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 ILE A 455
THR A 335
VAL A 334
LEU A 444
ILE A 383
 None
 1.29A 1kqwA-3kxwA:
undetectable		 1kqwA-3kxwA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 5 ARG A 560
ILE A 471
PRO A 468
GLU A 472
 None
 1.10A 1oniG-3kxwA:
undetectable
1oniH-3kxwA:
undetectable		 1oniG-3kxwA:
13.60
1oniH-3kxwA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 5 CYH A 559
PRO A 569
THR A 537
THR A 501
 None
 1.30A 1ymxB-3kxwA:
undetectable		 1ymxB-3kxwA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 LEU A 248
ASN A 246
LEU A 244
MET A 238
SER A 239
 None
 1.44A 2aa5B-3kxwA:
undetectable		 2aa5B-3kxwA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 5 VAL A 451
THR A 452
VAL A 397
GLY A 398
 1ZZ  A 589 (-4.4A)
None
None
None
 1.06A 2p2fA-3kxwA:
32.6		 2p2fA-3kxwA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 LEU A 221
LEU A 226
SER A  27
LEU A  44
VAL A  15
 None
 1.14A 2po7A-3kxwA:
3.9		 2po7A-3kxwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 LEU A 221
LEU A 226
SER A  27
LEU A  44
VAL A  15
 None
 1.14A 2po7B-3kxwA:
undetectable		 2po7B-3kxwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 5 GLN A 171
PHE A 169
PHE A  80
GLY A 220
 None
 1.23A 2qmzA-3kxwA:
3.3
2qmzB-3kxwA:
3.7		 2qmzA-3kxwA:
16.95
2qmzB-3kxwA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 5 GLN A 171
PHE A 169
PHE A  80
GLY A 223
 None
None
None
1ZZ  A 589 (-3.8A)
 1.12A 2qmzA-3kxwA:
3.3
2qmzB-3kxwA:
3.7		 2qmzA-3kxwA:
16.95
2qmzB-3kxwA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 ASP A 440
VAL A 451
THR A 335
VAL A 334
ASP A 218
 1ZZ  A 589 (-2.8A)
1ZZ  A 589 (-4.4A)
None
None
1ZZ  A 589 (-2.5A)
 0.97A 2x0yA-3kxwA:
undetectable		 2x0yA-3kxwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 LEU A 191
ILE A 233
GLY A 231
ILE A 229
VAL A  14
 None
 1.02A 3bwcB-3kxwA:
undetectable		 3bwcB-3kxwA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 9 TYR A 269
PHE A 321
PRO A 323
GLY A 263
ILE A 254
 None
 1.30A 3csjB-3kxwA:
undetectable		 3csjB-3kxwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 6 LEU A 519
PHE A 520
ILE A 538
PHE A 267
 None
 0.99A 3ko0B-3kxwA:
undetectable		 3ko0B-3kxwA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 6 ILE A 538
LEU A 540
GLU A 522
ALA A 515
 None
 0.85A 3r9sA-3kxwA:
undetectable		 3r9sA-3kxwA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 5 ALA A 268
GLU A 534
GLU A 297
MET A 219
 None
None
None
1ZZ  A 589 ( 3.9A)
 1.09A 3r9tC-3kxwA:
undetectable		 3r9tC-3kxwA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		3 / 3 THR A 438
VAL A 402
GLU A 329
 None
None
1ZZ  A 589 ( 4.9A)
 0.69A 3v4tA-3kxwA:
0.0
3v4tD-3kxwA:
undetectable		 3v4tA-3kxwA:
21.30
3v4tD-3kxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 TYR A  41
LEU A 332
LEU A  84
LEU A  11
ALA A  90
 None
1ZZ  A 589 (-4.6A)
None
None
None
 1.17A 3vw7A-3kxwA:
undetectable		 3vw7A-3kxwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 LEU A 332
LEU A 333
ASN A 193
MET A 203
THR A 227
 1ZZ  A 589 (-4.6A)
1ZZ  A 589 ( 4.2A)
None
None
None
 1.41A 3zqtA-3kxwA:
undetectable		 3zqtA-3kxwA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 5 TYR A 462
LEU A 458
TYR A 498
ARG A 560
 None
 1.47A 4em2A-3kxwA:
undetectable		 4em2A-3kxwA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 ALA A  50
ALA A  53
ALA A  52
VAL A  66
LEU A 118
 None
 1.14A 4j6dB-3kxwA:
undetectable		 4j6dB-3kxwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 9 ALA A  53
THR A  54
ALA A  57
GLY A  82
ALA A  86
 None
 1.20A 4qvnK-3kxwA:
undetectable
4qvnL-3kxwA:
undetectable		 4qvnK-3kxwA:
14.48
4qvnL-3kxwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		3 / 3 MET A 178
GLN A 532
TYR A  94
 None
 0.88A 4udcA-3kxwA:
undetectable		 4udcA-3kxwA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 HIS A 187
LEU A  11
PHE A  80
LEU A  81
ARG A  65
 None
 0.97A 5hnxB-3kxwA:
undetectable		 5hnxB-3kxwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 VAL A 185
LEU A  11
PHE A  80
LEU A  81
ARG A  65
 None
 1.37A 5hnxB-3kxwA:
undetectable		 5hnxB-3kxwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 8 ILE A 149
ALA A  50
ALA A  57
GLU A  58
 None
 0.71A 5mvmA-3kxwA:
undetectable
5mvmB-3kxwA:
undetectable		 5mvmA-3kxwA:
10.36
5mvmB-3kxwA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		5 / 12 ASP A 166
ILE A 162
ILE A  89
GLY A  63
LEU A  84
 None
 1.04A 5twjC-3kxwA:
undetectable		 5twjC-3kxwA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		3 / 3 GLU A 534
HIS A 536
ARG A 300
 None
 0.99A 5uunA-3kxwA:
1.2		 5uunA-3kxwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 5 VAL A 491
PRO A 468
GLY A 463
TYR A 467
 None
 1.16A 5x80A-3kxwA:
undetectable
5x80B-3kxwA:
undetectable		 5x80A-3kxwA:
14.09
5x80B-3kxwA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 5 PRO A 468
GLY A 463
TYR A 467
VAL A 491
 None
 1.19A 5x80C-3kxwA:
undetectable
5x80D-3kxwA:
undetectable		 5x80C-3kxwA:
14.09
5x80D-3kxwA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 5 ASN A 447
VAL A 358
LEU A 348
SER A 373
 None
 1.23A 6a7pA-3kxwA:
undetectable		 6a7pA-3kxwA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		3 / 3 TYR A 322
HIS A 202
MET A 203
 None
 1.21A 6af6A-3kxwA:
undetectable		 6af6A-3kxwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3kxw SAFRAMYCIN MX1
SYNTHETASE B
(Legionella
pneumophila) 		4 / 7 ASP A  45
ARG A  16
TYR A  85
ASP A  13
 None
 1.07A 6mn5E-3kxwA:
undetectable		 6mn5E-3kxwA:
9.03