SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ky9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 6 LEU A 145
ILE A  75
ARG A  76
VAL A 108
 None
 1.10A 1db1A-3ky9A:
undetectable		 1db1A-3ky9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 8 GLU A 207
LEU A 258
ALA A 257
LEU A 266
 None
 0.92A 1hwiB-3ky9A:
undetectable		 1hwiB-3ky9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 8 GLU A 207
LEU A 258
ALA A 257
LEU A 266
 None
 0.94A 1hwiD-3ky9A:
undetectable		 1hwiD-3ky9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 8 GLU A 207
LEU A 258
ALA A 257
LEU A 266
 None
 0.93A 1hwiC-3ky9A:
undetectable		 1hwiC-3ky9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 12 THR A 111
ARG A   5
VAL A 108
LEU A  33
LEU A  46
 None
 1.27A 1kqwA-3ky9A:
undetectable		 1kqwA-3ky9A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 8 ILE A 433
LEU A 431
MET A 496
LYS A 492
 None
 1.01A 1os6A-3ky9A:
undetectable		 1os6A-3ky9A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 8 VAL A 447
ARG A 417
GLU A 415
ASP A 445
 None
 1.24A 1s3zA-3ky9A:
undetectable
1s3zB-3ky9A:
undetectable		 1s3zA-3ky9A:
14.02
1s3zB-3ky9A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 12 LEU A 334
LYS A 335
GLY A 170
ASP A 171
ALA A 168
 None
 1.14A 2br4E-3ky9A:
undetectable		 2br4E-3ky9A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 12 TYR A 541
HIS A 554
CYH A 529
LYS A 530
LEU A 536
 None
ZN  A 901 (-3.3A)
ZN  A 901 (-2.5A)
None
None
 1.41A 2r3aA-3ky9A:
undetectable		 2r3aA-3ky9A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		3 / 3 ARG A 381
GLU A 372
SER A 289
 None
 0.73A 2xkkA-3ky9A:
undetectable
2xkkC-3ky9A:
undetectable		 2xkkA-3ky9A:
21.34
2xkkC-3ky9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		3 / 3 PHE A  78
CYH A  82
PHE A  86
 None
 1.06A 3cr5X-3ky9A:
1.1		 3cr5X-3ky9A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 12 LEU A  33
ALA A  36
LEU A  43
LEU A  42
LEU A  99
 None
 1.20A 3erdA-3ky9A:
undetectable		 3erdA-3ky9A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 12 TYR A 541
HIS A 554
CYH A 529
LYS A 530
LEU A 536
 None
ZN  A 901 (-3.3A)
ZN  A 901 (-2.5A)
None
None
 1.31A 3ooiA-3ky9A:
undetectable		 3ooiA-3ky9A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		3 / 3 GLN A   6
GLU A   2
LYS A   2
 None
 1.13A 3su9A-3ky9A:
undetectable		 3su9A-3ky9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 6 ASP A 376
THR A 384
ILE A 383
THR A 539
 None
 1.07A 4acbC-3ky9A:
undetectable		 4acbC-3ky9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 7 ARG A  63
PRO A  18
SER A  20
VAL A 163
 None
 1.19A 4klrA-3ky9A:
undetectable		 4klrA-3ky9A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 6 ASP A 171
GLU A 166
VAL A 370
ALA A 367
 None
 1.07A 4nkvC-3ky9A:
undetectable		 4nkvC-3ky9A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 7 ASN A 448
LEU A 427
ILE A 503
ILE A 506
 None
 0.76A 4ojbA-3ky9A:
undetectable		 4ojbA-3ky9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 11 LEU A  33
ALA A  36
LEU A  43
LEU A  42
LEU A  99
 None
 1.23A 4zn7B-3ky9A:
undetectable		 4zn7B-3ky9A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 7 LEU A 472
VAL A 454
GLU A 500
ILE A 433
 None
 0.86A 5jh7C-3ky9A:
undetectable		 5jh7C-3ky9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 12 LEU A  70
PRO A  64
SER A  67
PHE A  69
ILE A  75
 None
 1.23A 5ljcA-3ky9A:
undetectable		 5ljcA-3ky9A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 5 ARG A 537
PHE A 277
LEU A 278
LEU A 334
 None
 1.29A 5veuH-3ky9A:
undetectable		 5veuH-3ky9A:
22.45