SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		4 / 7 ASP A 239
TYR A 161
MET A 334
ASP A 332
 EDO  A 347 (-3.9A)
None
None
None
 1.48A 1t03A-3kydA:
undetectable		 1t03A-3kydA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		4 / 7 ASP A 239
TYR A 294
MET A 334
ASP A 332
 EDO  A 347 (-3.9A)
None
None
None
 1.32A 1t03A-3kydA:
undetectable		 1t03A-3kydA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		5 / 10 ARG B 122
ASP B  48
GLY B  29
GLY B  26
ILE B  96
 None
 0.78A 1x7pA-3kydB:
4.1
1x7pB-3kydB:
3.9		 1x7pA-3kydB:
19.61
1x7pB-3kydB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 8 VAL B  68
GLY B  69
THR B  51
ILE B 175
 None
 0.75A 2a1mB-3kydB:
undetectable		 2a1mB-3kydB:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 6 LEU B  81
ILE B  44
VAL B  37
ALA B  87
 None
 0.94A 2j5mA-3kydB:
undetectable		 2j5mA-3kydB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens;
Homo
sapiens) 		4 / 5 PRO B  85
PRO A  76
GLY A  77
TYR B  84
 None
 1.11A 2jkjD-3kydB:
undetectable		 2jkjD-3kydB:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens;
Homo
sapiens) 		4 / 5 PRO B  85
PRO A  76
GLY A  77
TYR B  84
 None
 1.10A 2jkjF-3kydB:
undetectable		 2jkjF-3kydB:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		5 / 12 GLY B  40
ASN B  88
GLY B  18
VAL B  22
ILE B  44
 None
 0.97A 2pymA-3kydB:
undetectable		 2pymA-3kydB:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		5 / 12 LEU A 318
ASP A 322
GLY A 308
THR B 389
LEU A  34
 None
 1.14A 2uvnA-3kydA:
undetectable		 2uvnA-3kydA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		4 / 8 LEU A 131
THR A 132
GLY A 307
ALA A 311
 None
 0.63A 3jusA-3kydA:
0.2		 3jusA-3kydA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		4 / 8 LEU A 131
THR A 132
GLY A 307
ALA A 311
 None
 0.63A 3jusA-3kydA:
0.2		 3jusA-3kydA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		4 / 6 ILE A 272
VAL A 276
LEU A 277
LEU A 287
 None
 0.86A 3kp6A-3kydA:
undetectable
3kp6B-3kydA:
undetectable		 3kp6A-3kydA:
19.83
3kp6B-3kydA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L7K_A_EDTA739_0
(TEICHOIC ACID
BIOSYNTHESIS PROTEIN
F)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		4 / 5 LEU A  28
LYS A  25
ARG A  33
LYS A  32
 None
 1.46A 3l7kA-3kydA:
4.8
3l7kB-3kydA:
5.0		 3l7kA-3kydA:
18.04
3l7kB-3kydA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 8 SER B  55
LEU B 258
TRP B 188
ASP B  53
 None
 1.17A 3n2oC-3kydB:
undetectable
3n2oD-3kydB:
undetectable		 3n2oC-3kydB:
20.24
3n2oD-3kydB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU B   7
SER A 297
SER A 259
TYR A 161
 None
 1.06A 3rodA-3kydB:
4.1		 3rodA-3kydB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		3 / 3 ASN B 118
GLU B 181
ARG B 176
 None
 1.07A 3wxoA-3kydB:
undetectable		 3wxoA-3kydB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		5 / 11 ILE B 416
ALA B 395
LEU B 397
VAL A 305
LEU B 418
 None
 1.06A 4g1bB-3kydB:
6.2		 4g1bB-3kydB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		3 / 3 ARG B 425
LYS B 426
LYS B 427
 None
 1.42A 4k50I-3kydB:
undetectable		 4k50I-3kydB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 6 SER B  79
GLY B  24
ASP B  48
GLY B  27
 None
 1.04A 4koeA-3kydB:
undetectable
4koeB-3kydB:
undetectable
4koeC-3kydB:
undetectable		 4koeA-3kydB:
22.26
4koeB-3kydB:
22.26
4koeC-3kydB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 6 LEU A  55
GLU A 313
VAL B 393
ALA B 392
 None
 1.16A 4nkvC-3kydA:
undetectable		 4nkvC-3kydA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		5 / 12 ILE B 326
ALA B 244
LEU B 192
THR B 256
LEU B 361
 None
 1.14A 4x5fA-3kydB:
undetectable		 4x5fA-3kydB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		3 / 3 MET A 299
ASP A 332
PHE A 330
 None
 1.07A 4xeyA-3kydA:
undetectable		 4xeyA-3kydA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		6 / 12 GLY B  24
GLY B  26
ASP B  48
ILE B  96
LEU B  32
LEU B 116
 None
 1.31A 5bw4A-3kydB:
5.5		 5bw4A-3kydB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 6 SER A 238
ARG B 414
GLY A 336
GLU B 401
 None
 1.08A 5cdqA-3kydA:
undetectable
5cdqC-3kydA:
undetectable
5cdqD-3kydA:
undetectable		 5cdqA-3kydA:
20.86
5cdqC-3kydA:
20.86
5cdqD-3kydA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		5 / 12 GLY B  24
ASP B  48
LEU B  49
SER B  95
ILE B  96
 None
 0.96A 5dpdB-3kydB:
6.7		 5dpdB-3kydB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 8 ILE B  44
ALA B  76
VAL B  80
VAL B  22
 None
 0.79A 5ecnD-3kydB:
undetectable		 5ecnD-3kydB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		4 / 4 LEU A  81
LEU A  44
GLY A  48
GLU A  50
 None
 1.17A 5hhjA-3kydA:
undetectable		 5hhjA-3kydA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		5 / 12 PHE A 328
TYR A 164
ALA A 219
ILE A 139
LEU A 310
 None
EDO  A 347 (-4.6A)
None
None
None
 1.22A 5ljbA-3kydA:
undetectable		 5ljbA-3kydA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		5 / 12 PHE A 328
TYR A 164
ALA A 219
ILE A 139
LEU A 310
 None
EDO  A 347 (-4.6A)
None
None
None
 1.26A 5ljcA-3kydA:
undetectable		 5ljcA-3kydA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		4 / 8 ASN A 168
GLU A 313
PHE A 154
TYR A 164
 None
None
None
EDO  A 347 (-4.6A)
 1.25A 5oh1C-3kydA:
undetectable		 5oh1C-3kydA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		5 / 12 ALA B  73
GLY B  29
ILE B 398
GLU B 138
LEU B 136
 None
 1.14A 5ul4A-3kydB:
4.1		 5ul4A-3kydB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 8 ARG B  59
ASN B  56
GLN B 195
ASP B  53
 None
 1.25A 5vunA-3kydB:
undetectable		 5vunA-3kydB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 8 ARG B  59
ASN B  56
GLN B 195
ASP B  53
 None
 1.17A 5vunB-3kydB:
undetectable		 5vunB-3kydB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 8 ARG B  59
ASN B  56
GLN B 195
ASP B  53
 None
 1.16A 5vuoB-3kydB:
undetectable		 5vuoB-3kydB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens) 		4 / 8 ARG B  59
ASN B  56
GLN B 195
ASP B  53
 None
 1.16A 6auuB-3kydB:
undetectable		 6auuB-3kydB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A  28
GLY A  27
SER A  37
ARG A 321
ASP A 322
 None
 1.29A 6bxlB-3kydA:
2.6		 6bxlB-3kydA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A  44
GLY A  43
VAL A 302
VAL A 158
ASP A 157
 None
 1.29A 6bxlB-3kydA:
2.6		 6bxlB-3kydA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		4 / 7 ALA A 219
GLY A 344
GLY A 170
ASN A 327
 None
 0.75A 6nm4A-3kydA:
undetectable		 6nm4A-3kydA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A  56
LEU A  63
ARG A  98
LEU A  44
 None
 0.96A 6nmfA-3kydA:
undetectable
6nmfJ-3kydA:
undetectable		 6nmfA-3kydA:
18.34
6nmfJ-3kydA:
9.83