SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 10 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.22A 1a52A-3kyeA:
undetectable		 1a52A-3kyeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 10 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.22A 1a52B-3kyeA:
undetectable		 1a52B-3kyeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 11 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.27A 1g50C-3kyeA:
undetectable		 1g50C-3kyeA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 10 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.25A 1pcgA-3kyeA:
undetectable		 1pcgA-3kyeA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 10 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.24A 1pcgB-3kyeA:
undetectable		 1pcgB-3kyeA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 10 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.26A 1qkuA-3kyeA:
undetectable		 1qkuA-3kyeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 10 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.27A 1qkuB-3kyeA:
undetectable		 1qkuB-3kyeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 10 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.26A 1qkuC-3kyeA:
undetectable		 1qkuC-3kyeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 12 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.23A 2j7xA-3kyeA:
undetectable		 2j7xA-3kyeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 12 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.24A 3olsB-3kyeA:
undetectable		 3olsB-3kyeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 11 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.22A 3uudA-3kyeA:
undetectable		 3uudA-3kyeA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 10 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.21A 3uudB-3kyeA:
undetectable		 3uudB-3kyeA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		4 / 7 LEU A  89
ALA A 101
LEU A 103
SER A  29
 None
 0.74A 4d7bA-3kyeA:
undetectable		 4d7bA-3kyeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		4 / 7 LEU A 100
ALA A  30
LEU A  32
SER A  41
 None
 0.75A 4d7bA-3kyeA:
undetectable		 4d7bA-3kyeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		4 / 6 LEU A 100
ALA A  30
LEU A  32
SER A  41
 None
 0.76A 4ikiB-3kyeA:
undetectable		 4ikiB-3kyeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 12 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.22A 4j24C-3kyeA:
undetectable		 4j24C-3kyeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 12 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.19A 4j26A-3kyeA:
undetectable		 4j26A-3kyeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 12 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.19A 4j26B-3kyeA:
undetectable		 4j26B-3kyeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		4 / 6 ALA A  30
LEU A  32
SER A  41
VAL A  21
 None
 1.25A 5a6iA-3kyeA:
undetectable		 5a6iA-3kyeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 11 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.21A 5dxbB-3kyeA:
undetectable		 5dxbB-3kyeA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 10 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.21A 5dxeB-3kyeA:
undetectable		 5dxeB-3kyeA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 9 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.21A 5dxgA-3kyeA:
undetectable		 5dxgA-3kyeA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 11 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.20A 5dxgB-3kyeA:
undetectable		 5dxgB-3kyeA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 10 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.19A 5hyrA-3kyeA:
undetectable		 5hyrA-3kyeA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 11 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.22A 5hyrB-3kyeA:
undetectable		 5hyrB-3kyeA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 12 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.25A 5toaB-3kyeA:
undetectable		 5toaB-3kyeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGD_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 9 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.22A 5wgdA-3kyeA:
undetectable		 5wgdA-3kyeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		5 / 10 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.23A 5wgqB-3kyeA:
undetectable		 5wgqB-3kyeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		4 / 6 TYR A 127
LEU A 120
LYS A  10
LEU A  32
 None
 1.30A 5xooA-3kyeA:
undetectable		 5xooA-3kyeA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7
(Streptomyces
avermitilis) 		4 / 8 LEU A  16
MET A  17
ARG A  23
LEU A 128
 None
 1.14A 6cbzA-3kyeA:
undetectable		 6cbzA-3kyeA:
22.54