SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 432
ASN A 431
LEU A 502
ILE A 497
 None
 1.02A 1z95A-3kyhA:
undetectable		 1z95A-3kyhA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.94A 2f81A-3kyhA:
undetectable		 2f81A-3kyhA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.94A 2f81B-3kyhA:
undetectable		 2f81B-3kyhA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.94A 2f8gA-3kyhA:
undetectable		 2f8gA-3kyhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.94A 2o4sA-3kyhA:
undetectable		 2o4sA-3kyhA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 1.03A 2qhcA-3kyhA:
undetectable		 2qhcA-3kyhA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 SER C 291
PHE C 317
ILE C 261
PRO C 265
 None
 0.96A 2y7kA-3kyhC:
undetectable		 2y7kA-3kyhC:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.96A 3cywB-3kyhA:
undetectable		 3cywB-3kyhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.96A 3d1zB-3kyhA:
undetectable		 3d1zB-3kyhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 1.00A 3ektD-3kyhA:
undetectable		 3ektD-3kyhA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.87A 3ekxA-3kyhA:
undetectable		 3ekxA-3kyhA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.95A 3lzsA-3kyhA:
undetectable		 3lzsA-3kyhA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.96A 3lzsB-3kyhA:
undetectable		 3lzsB-3kyhA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.97A 3lzuA-3kyhA:
undetectable		 3lzuA-3kyhA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.91A 3ndtD-3kyhA:
undetectable		 3ndtD-3kyhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.90A 3oxcA-3kyhA:
undetectable		 3oxcA-3kyhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.94A 3pwmB-3kyhA:
undetectable		 3pwmB-3kyhA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 4 SER C 387
GLY C 226
GLU C 132
 None
 0.69A 3raeA-3kyhC:
undetectable
3raeC-3kyhC:
undetectable		 3raeA-3kyhC:
23.43
3raeC-3kyhC:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 307
LYS A 409
ARG A 458
GLU A 494
 None
 1.31A 3tj7C-3kyhA:
8.9		 3tj7C-3kyhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.96A 3tkwA-3kyhA:
undetectable		 3tkwA-3kyhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 THR A 522
ASN A 525
GLY A 527
ILE A 470
 None
 1.04A 3w9tF-3kyhA:
undetectable		 3w9tF-3kyhA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 THR A 522
ASN A 526
GLY A 527
ILE A 428
 None
 0.89A 3w9tF-3kyhA:
undetectable		 3w9tF-3kyhA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 THR A 292
HIS A 338
LEU A 416
 None
 0.56A 5axdA-3kyhA:
undetectable		 5axdA-3kyhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 GLY C  73
PRO C 221
THR C  71
GLN C 136
 None
 1.06A 5h5fA-3kyhC:
undetectable		 5h5fA-3kyhC:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 337
ASP A 336
ASP A 315
VAL A 322
ILE A 313
 None
 0.96A 5t2zA-3kyhA:
undetectable		 5t2zA-3kyhA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 321
VAL A 426
ASP A 425
TYR A 418
 None
 1.02A 5vlmA-3kyhA:
undetectable		 5vlmA-3kyhA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 3kyh MRNA-CAPPING ENZYME
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 MET A 308
ASN A 342
VAL A 493
LEU A 495
 None
 1.21A 5xdhA-3kyhA:
undetectable
5xdhC-3kyhA:
undetectable		 5xdhA-3kyhA:
12.50
5xdhC-3kyhA:
12.50