SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		5 / 9 ASP A 310
LEU A 306
GLY A 314
HIS A 287
ILE A 216
 None
None
G  E   3 ( 4.6A)
None
None
 1.29A 1sq5A-3kylA:
0.0		 1sq5A-3kylA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		5 / 10 ASP A 310
LEU A 306
GLY A 314
HIS A 287
ILE A 216
 None
None
G  E   3 ( 4.6A)
None
None
 1.32A 1sq5B-3kylA:
undetectable		 1sq5B-3kylA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		5 / 9 ASP A 310
LEU A 306
GLY A 314
HIS A 287
ILE A 216
 None
None
G  E   3 ( 4.6A)
None
None
 1.30A 1sq5C-3kylA:
0.0		 1sq5C-3kylA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		5 / 10 ASP A 310
LEU A 306
GLY A 314
HIS A 287
ILE A 216
 None
None
G  E   3 ( 4.6A)
None
None
 1.29A 1sq5D-3kylA:
undetectable		 1sq5D-3kylA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		5 / 12 ILE A  55
ILE A  56
ALA A  30
LEU A 123
PHE A  61
 None
 1.11A 1xzxX-3kylA:
undetectable		 1xzxX-3kylA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		3 / 3 LYS A 584
TYR A 577
PRO A 582
 None
 1.23A 2j9cC-3kylA:
2.9		 2j9cC-3kylA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		5 / 11 VAL A 588
LEU A 581
VAL A 543
ILE A 472
ALA A 480
 None
 1.14A 2zbzA-3kylA:
undetectable		 2zbzA-3kylA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		5 / 12 CYH A 315
SER A 313
HIS A 287
ILE A 288
LEU A 264
 None
 1.25A 3cs8A-3kylA:
undetectable		 3cs8A-3kylA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		5 / 8 GLY A 391
CYH A 348
CYH A 233
PHE A 451
PHE A 457
 None
 1.41A 3ko0D-3kylA:
undetectable
3ko0E-3kylA:
undetectable		 3ko0D-3kylA:
10.70
3ko0E-3kylA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		4 / 7 ASP A 325
VAL A 250
ILE A 248
TYR A 345
 None
 0.96A 3pglA-3kylA:
undetectable		 3pglA-3kylA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		5 / 12 ILE A  48
LEU A 123
LEU A  78
ILE A  77
ILE A  55
 None
 0.99A 3vrmA-3kylA:
undetectable		 3vrmA-3kylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		4 / 7 ILE A 288
GLN A 291
GLY A 305
VAL A 259
 None
 0.89A 4a3uB-3kylA:
undetectable		 4a3uB-3kylA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		5 / 11 HIS A  87
VAL A 491
ILE A 426
LEU A 419
ALA A 432
 None
 1.38A 4m83A-3kylA:
undetectable		 4m83A-3kylA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		3 / 3 LYS A 406
ARG A 402
VAL A 401
 None
 0.88A 4x3uA-3kylA:
undetectable
4x3uB-3kylA:
undetectable		 4x3uA-3kylA:
6.90
4x3uB-3kylA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		4 / 6 LEU A 404
ASP A 469
GLU A 452
ILE A 387
 None
 1.08A 4xi3C-3kylA:
undetectable		 4xi3C-3kylA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		4 / 8 ASP A 343
ASP A 344
ASP A 251
ILE A 387
 MG  A 597 (-3.1A)
MG  A 597 (-2.6A)
MG  A 597 (-2.9A)
None
 1.06A 4xjeA-3kylA:
1.5		 4xjeA-3kylA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		3 / 3 CYH A  37
LYS A  38
HIS A  40
 None
 1.04A 5js5A-3kylA:
undetectable		 5js5A-3kylA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		3 / 3 CYH A  37
LYS A  39
HIS A  40
 None
 0.98A 5js5A-3kylA:
undetectable		 5js5A-3kylA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		3 / 3 LYS A 260
PRO A 262
LYS A 266
 None
 1.11A 5y9yA-3kylA:
undetectable		 5y9yA-3kylA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3kyl TELOMERASE REVERSE
TRANSCRIPTASE
(Tribolium
castaneum) 		3 / 3 LEU A 114
ASN A  20
LEU A  27
 None
 0.71A 6exiD-3kylA:
undetectable		 6exiD-3kylA:
8.72