SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA181_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		4 / 4 THR A 190
ARG A 202
HIS A 192
HIS A 191
 None
 1.11A 1gtnA-3kyoA:
0.5		 1gtnA-3kyoA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		3 / 3 GLU A 128
GLU A 161
LEU A 103
 None
 0.70A 1v8bA-3kyoA:
undetectable		 1v8bA-3kyoA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		3 / 3 TRP A 167
GLU A  63
TYR A  59
 None
 1.09A 2a3aA-3kyoA:
undetectable		 2a3aA-3kyoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		5 / 10 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
 None
 1.37A 2wuzA-3kyoA:
undetectable		 2wuzA-3kyoA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		5 / 10 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
 None
 1.34A 2wuzB-3kyoA:
undetectable		 2wuzB-3kyoA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		4 / 8 TYR A   7
ARG A  35
VAL A  28
TYR A 171
 None
 1.33A 2y05A-3kyoA:
undetectable
2y05B-3kyoA:
undetectable		 2y05A-3kyoA:
21.52
2y05B-3kyoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.94A 2zm8A-3kyoA:
undetectable		 2zm8A-3kyoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.99A 2zmaA-3kyoA:
undetectable		 2zmaA-3kyoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		4 / 7 ARG A 202
ALA A 246
VAL A 194
VAL A 248
 None
 0.73A 3o14A-3kyoA:
undetectable		 3o14A-3kyoA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		3 / 3 TYR A 171
TYR A   7
GLU A 166
 None
 0.75A 3pfgA-3kyoA:
undetectable		 3pfgA-3kyoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		5 / 12 ALA A 140
ASP A  74
GLU A 114
LEU A  95
THR A  73
 None
 1.42A 4zjoA-3kyoA:
undetectable		 4zjoA-3kyoA:
12.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		3 / 3 PRO A  47
ARG A  48
GLU A  53
 None
 0.68A 5j6hA-3kyoA:
33.3		 5j6hA-3kyoA:
72.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		4 / 4 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
 1.50A 5m5kA-3kyoA:
undetectable		 5m5kA-3kyoA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		4 / 7 PHE A  36
ALA A  71
GLN A  72
GLN A  32
 None
 1.30A 6b89A-3kyoA:
undetectable		 6b89A-3kyoA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		4 / 4 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
 1.46A 6f3mB-3kyoA:
undetectable		 6f3mB-3kyoA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3kyo MHC CLASS I ANTIGEN
(Homo
sapiens) 		4 / 5 ALA A 135
TYR A 123
GLN A 141
ILE A 142
 None
 1.32A 6f6sA-3kyoA:
undetectable
6f6sB-3kyoA:
undetectable		 6f6sA-3kyoA:
16.67
6f6sB-3kyoA:
13.92