SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3kys TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-1
(Homo
sapiens) 		4 / 8 GLY A 400
ILE A 351
VAL A 293
SER A 395
 None
 0.89A 2yoeB-3kysA:
undetectable
2yoeC-3kysA:
undetectable		 2yoeB-3kysA:
21.43
2yoeC-3kysA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3kys TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-1
(Homo
sapiens) 		5 / 12 VAL A 293
SER A 295
ILE A 372
VAL A 376
LEU A 386
 None
None
BME  A 700 ( 4.9A)
None
None
 1.23A 3w67D-3kysA:
undetectable		 3w67D-3kysA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3kys TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-1
(Homo
sapiens) 		4 / 5 ILE A 372
LEU A 203
HIS A 226
VAL A 225
 BME  A 700 ( 4.9A)
None
None
None
 1.24A 5jmnB-3kysA:
undetectable		 5jmnB-3kysA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3kys TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-1
(Homo
sapiens) 		4 / 6 LEU A 258
TYR A 248
PHE A 270
GLY A 263
 None
 0.98A 6hd4B-3kysA:
undetectable		 6hd4B-3kysA:
22.51