SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kz1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		4 / 6 LYS A 797
CYH A 793
LEU A 750
ARG A 754
 None
 1.42A 1oafA-3kz1A:
undetectable		 1oafA-3kz1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		5 / 10 MET A 796
LEU A 812
GLU A 902
LEU A 906
LEU A 742
 None
 1.41A 1pcgB-3kz1A:
undetectable		 1pcgB-3kz1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		5 / 12 SER A 877
LEU A 785
VAL A 828
ALA A 923
ALA A 830
 None
 1.34A 1q23A-3kz1A:
undetectable
1q23B-3kz1A:
undetectable		 1q23A-3kz1A:
19.84
1q23B-3kz1A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		5 / 12 LEU A 775
LEU A 842
ALA A 839
MET A 764
MET A 857
 None
 1.01A 1ya3A-3kz1A:
undetectable		 1ya3A-3kz1A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		4 / 8 LEU A 825
HIS A 749
GLU A 878
ALA A 829
 None
 0.82A 2bnnA-3kz1A:
undetectable
2bnnB-3kz1A:
undetectable		 2bnnA-3kz1A:
20.21
2bnnB-3kz1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		4 / 5 ILE A 786
PRO A 783
PHE A 832
PHE A 779
 None
 0.98A 2hjhA-3kz1A:
undetectable		 2hjhA-3kz1A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		4 / 7 GLU A 824
ALA A 830
ASN A 781
ALA A 829
 None
 1.14A 2zgwA-3kz1A:
1.6		 2zgwA-3kz1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		4 / 6 GLU A 824
ALA A 830
ASN A 781
ALA A 829
 None
 1.14A 2zgwB-3kz1A:
undetectable		 2zgwB-3kz1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		3 / 3 ASP A 818
ASP A 911
ASP A 811
 None
 0.75A 3douA-3kz1A:
undetectable		 3douA-3kz1A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		6 / 12 MET A 796
LEU A 812
GLU A 902
LEU A 889
LEU A 906
LEU A 742
 None
 1.35A 3erdA-3kz1A:
undetectable		 3erdA-3kz1A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		5 / 10 MET A 796
GLU A 902
LEU A 889
LEU A 906
LEU A 742
 None
 1.23A 3erdB-3kz1A:
undetectable		 3erdB-3kz1A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		4 / 6 MET A 879
LEU A 882
PRO A 886
TYR A 885
 None
 1.21A 3vkxA-3kz1A:
undetectable		 3vkxA-3kz1A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		5 / 10 LEU A 995
LEU A 940
LEU A 961
LEU A 987
LEU A1026
 None
 1.06A 4odoA-3kz1A:
undetectable		 4odoA-3kz1A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		5 / 10 LEU A 995
LEU A 940
LEU A 961
LEU A 987
LEU A1026
 None
 1.10A 4odoB-3kz1A:
undetectable		 4odoB-3kz1A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		4 / 5 ARG A 975
THR A 981
THR A 973
ASP A 983
 None
 1.49A 4oltB-3kz1A:
0.0		 4oltB-3kz1A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		4 / 5 ARG A 975
THR A 981
THR A 973
ASP A 983
 None
 1.49A 4qwpB-3kz1A:
1.2		 4qwpB-3kz1A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		5 / 12 ARG A 822
ALA A 821
ARG A 816
ALA A 830
TYR A 919
 None
 1.03A 4r29C-3kz1A:
2.0		 4r29C-3kz1A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		3 / 3 GLU A 928
ILE A 876
ALA A 839
 None
 0.49A 4wnwB-3kz1A:
undetectable		 4wnwB-3kz1A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		5 / 12 MET A 796
LEU A 812
GLU A 902
LEU A 889
LEU A 906
 None
 1.17A 4zn7A-3kz1A:
undetectable		 4zn7A-3kz1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		6 / 11 MET A 796
LEU A 812
GLU A 902
LEU A 889
LEU A 906
LEU A 742
 None
 1.37A 4zn7B-3kz1A:
undetectable		 4zn7B-3kz1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		5 / 9 MET A 796
LEU A 812
GLU A 902
LEU A 906
LEU A 742
 None
 1.50A 5dxgA-3kz1A:
undetectable		 5dxgA-3kz1A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens) 		3 / 3 LYS A 998
LEU A1003
ARG A 939
 None
 0.78A 5yw0A-3kz1A:
undetectable		 5yw0A-3kz1A:
25.81