SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN
(Legionella
pneumophila) 		5 / 9 ASP A  46
GLY A 208
ILE A  88
VAL A  83
ILE A  84
 None
 1.06A 2q5kA-3kzgA:
undetectable		 2q5kA-3kzgA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN
(Legionella
pneumophila) 		5 / 9 ASP A  46
GLY A 208
ILE A  88
VAL A  83
ILE A  84
 None
 0.91A 2r5qA-3kzgA:
undetectable		 2r5qA-3kzgA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN
(Legionella
pneumophila) 		5 / 9 ASP A  46
GLY A 208
ILE A  88
VAL A  83
ILE A  84
 None
 0.91A 2r5qC-3kzgA:
undetectable		 2r5qC-3kzgA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN
(Legionella
pneumophila) 		4 / 7 MET A  50
ILE A 211
ILE A 221
GLN A 217
 None
 0.97A 3hgxA-3kzgA:
undetectable		 3hgxA-3kzgA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN
(Legionella
pneumophila) 		5 / 12 ALA A 213
LEU A 220
ILE A  53
LEU A  57
LEU A  21
 None
 0.99A 3k2hA-3kzgA:
undetectable		 3k2hA-3kzgA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN
(Legionella
pneumophila) 		5 / 9 ASP A  46
ILE A 211
GLY A 208
ILE A  88
ILE A  84
 None
 0.98A 3nu4A-3kzgA:
undetectable		 3nu4A-3kzgA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN
(Legionella
pneumophila) 		5 / 9 ASP A  46
ILE A 211
GLY A 208
ILE A  88
VAL A  83
 None
 1.09A 3nu4A-3kzgA:
undetectable		 3nu4A-3kzgA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN
(Legionella
pneumophila) 		5 / 9 ASP A  46
GLY A 208
ILE A  88
VAL A  83
ILE A  84
 None
 0.99A 3nuoA-3kzgA:
undetectable		 3nuoA-3kzgA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A 241
ILE A 211
LEU A 228
GLU A 232
PHE A  45
 None
 1.38A 4b9zA-3kzgA:
undetectable		 4b9zA-3kzgA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN
(Legionella
pneumophila) 		4 / 5 LEU A  49
ASP A  46
TYR A 237
LEU A 240
 None
 1.06A 4wozF-3kzgA:
undetectable
4wozH-3kzgA:
undetectable		 4wozF-3kzgA:
23.23
4wozH-3kzgA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN
(Legionella
pneumophila) 		5 / 10 ASP A  46
GLY A 208
ILE A  88
VAL A  83
ILE A  84
 None
 0.95A 6dj2A-3kzgA:
undetectable		 6dj2A-3kzgA:
15.84