SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		3 / 3 ARG A  29
GLN A  11
PRO A 232
 None
 1.00A 2qhfA-3kzpA:
undetectable		 2qhfA-3kzpA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		4 / 5 PHE A 112
PHE A  59
PHE A  37
ILE A 103
 None
 1.25A 2v0mD-3kzpA:
undetectable		 2v0mD-3kzpA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		5 / 11 PHE A 171
LEU A 181
ILE A 179
PHE A 176
VAL A 221
 None
None
CL  A 239 (-4.8A)
None
CL  A 236 ( 4.8A)
 1.25A 3a9eB-3kzpA:
undetectable		 3a9eB-3kzpA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		3 / 3 ASP A 147
ASN A  78
SER A 172
 CA  A 240 (-2.9A)
CA  A 240 ( 2.8A)
None
 0.60A 3lslA-3kzpA:
undetectable
3lslD-3kzpA:
undetectable		 3lslA-3kzpA:
21.27
3lslD-3kzpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		3 / 3 SER A 172
ASP A 147
ASN A  78
 None
CA  A 240 (-2.9A)
CA  A 240 ( 2.8A)
 0.72A 3lslA-3kzpA:
undetectable
3lslD-3kzpA:
undetectable		 3lslA-3kzpA:
21.27
3lslD-3kzpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		4 / 8 ARG A 158
VAL A 159
TYR A 165
ILE A 166
 None
 0.97A 3remA-3kzpA:
undetectable		 3remA-3kzpA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		4 / 8 ARG A 158
VAL A 159
TYR A 165
ILE A 166
 None
 0.98A 3remB-3kzpA:
undetectable		 3remB-3kzpA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		4 / 8 ASN A  78
ASP A 148
SER A 172
HIS A 175
 CA  A 240 ( 2.8A)
None
None
None
 0.89A 3sg9B-3kzpA:
1.3		 3sg9B-3kzpA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		4 / 8 ASP A 148
SER A 172
HIS A 175
GLU A  23
 None
 1.04A 3sg9B-3kzpA:
1.3		 3sg9B-3kzpA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		3 / 3 TYR A 165
LEU A  96
LYS A  97
 None
 0.73A 3sueD-3kzpA:
undetectable		 3sueD-3kzpA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		4 / 8 PHE A  59
PHE A  55
ALA A  80
THR A 108
 None
 0.89A 3t3sD-3kzpA:
undetectable		 3t3sD-3kzpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		5 / 10 THR A 108
VAL A 105
GLU A 106
GLU A  25
ILE A 137
 None
None
CA  A 240 (-3.3A)
CA  A 240 (-2.9A)
None
 1.36A 3uayA-3kzpA:
undetectable		 3uayA-3kzpA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		4 / 6 HIS A 143
GLU A  23
ASP A  15
ASP A 201
 None
 1.34A 4blvA-3kzpA:
undetectable		 4blvA-3kzpA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		4 / 7 PHE A  55
ALA A  80
THR A 108
LEU A  28
 None
None
None
CL  A 237 (-4.4A)
 0.83A 4ejgA-3kzpA:
undetectable		 4ejgA-3kzpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		4 / 6 ASN A 198
ILE A 146
ILE A 169
VAL A 149
 None
 1.00A 4olmA-3kzpA:
undetectable		 4olmA-3kzpA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		5 / 11 LEU A  96
ILE A 137
PHE A  63
ILE A  77
ILE A 103
 None
 1.08A 6ebzA-3kzpA:
undetectable		 6ebzA-3kzpA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		5 / 11 LEU A  96
ILE A 137
PHE A  63
ILE A  77
ILE A 103
 None
 1.07A 6ebzB-3kzpA:
undetectable		 6ebzB-3kzpA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		5 / 11 LEU A  96
ILE A 137
PHE A  63
ILE A  77
ILE A 103
 None
 1.02A 6ebzD-3kzpA:
undetectable		 6ebzD-3kzpA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		5 / 11 LEU A  96
ILE A 137
PHE A  63
ILE A  77
ILE A 103
 None
 0.92A 6gp2A-3kzpA:
undetectable		 6gp2A-3kzpA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE
(Listeria
monocytogenes) 		5 / 11 LEU A  96
ILE A 137
PHE A  63
ILE A  77
ILE A 103
 None
 0.89A 6gp2B-3kzpA:
undetectable		 6gp2B-3kzpA:
15.46