SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		5 / 10 GLY A   9
VAL A  34
ARG A  36
ILE A  59
GLY A  87
 GOL  A 255 (-3.3A)
None
None
None
GOL  A 255 ( 4.7A)
 1.35A 1fohA-3kzvA:
3.0		 1fohA-3kzvA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		5 / 10 GLY A   9
VAL A  34
ARG A  36
ILE A  59
GLY A  87
 GOL  A 255 (-3.3A)
None
None
None
GOL  A 255 ( 4.7A)
 1.36A 1fohB-3kzvA:
undetectable		 1fohB-3kzvA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		5 / 10 GLY A   9
VAL A  34
ARG A  36
ILE A  59
GLY A  87
 GOL  A 255 (-3.3A)
None
None
None
GOL  A 255 ( 4.7A)
 1.35A 1fohC-3kzvA:
undetectable		 1fohC-3kzvA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		5 / 10 GLY A   9
VAL A  34
ARG A  36
ILE A  59
GLY A  87
 GOL  A 255 (-3.3A)
None
None
None
GOL  A 255 ( 4.7A)
 1.35A 1fohD-3kzvA:
undetectable		 1fohD-3kzvA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		5 / 10 GLY A   9
VAL A  34
ARG A  36
ILE A  59
GLY A  87
 GOL  A 255 (-3.3A)
None
None
None
GOL  A 255 ( 4.7A)
 1.37A 1pn0A-3kzvA:
undetectable		 1pn0A-3kzvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		5 / 10 GLY A   9
VAL A  34
ARG A  36
ILE A  59
GLY A  87
 GOL  A 255 (-3.3A)
None
None
None
GOL  A 255 ( 4.7A)
 1.37A 1pn0B-3kzvA:
undetectable		 1pn0B-3kzvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  35
GLY A  33
PHE A  52
LEU A  65
GLN A  67
 GOL  A 255 (-3.5A)
None
None
None
None
 1.17A 1qabF-3kzvA:
undetectable		 1qabF-3kzvA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		5 / 12 SER A 113
THR A  60
VAL A  34
LEU A 157
ALA A  86
 None
 1.26A 3d91B-3kzvA:
undetectable		 3d91B-3kzvA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		4 / 8 GLY A   9
ILE A  14
VAL A 135
VAL A  83
 GOL  A 255 (-3.3A)
None
None
None
 0.74A 3fi0B-3kzvA:
undetectable		 3fi0B-3kzvA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		4 / 8 GLY A   9
ILE A  14
VAL A 135
VAL A  83
 GOL  A 255 (-3.3A)
None
None
None
 0.73A 3fi0I-3kzvA:
undetectable		 3fi0I-3kzvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		5 / 12 GLY A   9
SER A  37
ASP A  58
ILE A  59
THR A  60
 GOL  A 255 (-3.3A)
GOL  A 255 (-4.6A)
None
None
None
 1.05A 3iv6A-3kzvA:
3.5		 3iv6A-3kzvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 178
GLY A  87
ASP A  58
ILE A  59
THR A  60
 None
GOL  A 255 ( 4.7A)
None
None
None
 1.28A 3iv6A-3kzvA:
3.5		 3iv6A-3kzvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  79
ALA A  84
THR A   8
VAL A  69
 None
 0.84A 3me6B-3kzvA:
undetectable		 3me6B-3kzvA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 244
ASP A 138
ASP A 182
 None
 0.71A 3ou7B-3kzvA:
5.7		 3ou7B-3kzvA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		4 / 4 SER A 243
TYR A 241
GLY A 179
PRO A 221
 None
 1.27A 4e3aA-3kzvA:
6.6		 4e3aA-3kzvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 160
PHE A 134
ALA A 165
LEU A 122
 None
 0.97A 4ejgD-3kzvA:
undetectable		 4ejgD-3kzvA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 117
LEU A 125
LEU A   6
ALA A  72
LYS A  78
 None
 1.11A 4x1iD-3kzvA:
5.8		 4x1iD-3kzvA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		4 / 6 LYS A  47
SER A  11
VAL A  10
ASP A  20
 None
GOL  A 255 (-2.8A)
None
None
 1.25A 5hesA-3kzvA:
undetectable		 5hesA-3kzvA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C
(Saccharomyces
cerevisiae) 		4 / 8 THR A 128
GLN A 170
VAL A 118
GLY A 119
 None
GOL  A 256 (-3.8A)
None
None
 1.04A 5nzyA-3kzvA:
2.2		 5nzyA-3kzvA:
20.34