SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 11 ILE A  20
PHE A  62
SER A 112
LEU A 109
ILE A  37
 None
 1.05A 1dg5A-3kzwA:
undetectable		 1dg5A-3kzwA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 LEU A  41
LEU A  44
SER A  40
HIS A  34
LEU A  16
 None
 1.34A 1fmlA-3kzwA:
undetectable		 1fmlA-3kzwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 THR A 135
PHE A  95
GLU A 132
GLY A 128
 None
 1.08A 1icrA-3kzwA:
undetectable
1icrB-3kzwA:
undetectable		 1icrA-3kzwA:
18.66
1icrB-3kzwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 GLU A 132
GLY A 128
THR A 135
PHE A  95
 None
 1.10A 1icrA-3kzwA:
undetectable
1icrB-3kzwA:
undetectable		 1icrA-3kzwA:
18.66
1icrB-3kzwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 THR A 135
PHE A  95
GLU A 132
GLY A 128
 None
 1.11A 1icuA-3kzwA:
undetectable
1icuB-3kzwA:
undetectable		 1icuA-3kzwA:
18.66
1icuB-3kzwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 GLU A 132
GLY A 128
THR A 135
PHE A  95
 None
 1.07A 1icuA-3kzwA:
undetectable
1icuB-3kzwA:
undetectable		 1icuA-3kzwA:
18.66
1icuB-3kzwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 THR A 135
PHE A  95
GLU A 132
GLY A 128
 None
 1.16A 1icuC-3kzwA:
undetectable
1icuD-3kzwA:
undetectable		 1icuC-3kzwA:
18.66
1icuD-3kzwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 THR A 135
PHE A  95
GLU A 132
GLY A 128
 None
 1.09A 1icvC-3kzwA:
undetectable
1icvD-3kzwA:
undetectable		 1icvC-3kzwA:
18.66
1icvD-3kzwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 GLU A 132
GLY A 128
THR A 135
PHE A  95
 None
 1.12A 1icvC-3kzwA:
undetectable
1icvD-3kzwA:
undetectable		 1icvC-3kzwA:
18.66
1icvD-3kzwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 THR A 135
PHE A  95
GLU A 132
GLY A 128
 None
 1.02A 1kqbA-3kzwA:
undetectable
1kqbB-3kzwA:
undetectable		 1kqbA-3kzwA:
17.97
1kqbB-3kzwA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 GLU A 132
GLY A 128
THR A 135
PHE A  95
 None
 1.06A 1kqbA-3kzwA:
undetectable
1kqbB-3kzwA:
undetectable		 1kqbA-3kzwA:
17.97
1kqbB-3kzwA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 THR A 135
PHE A  95
GLU A 132
GLY A 128
 None
 1.04A 1kqbC-3kzwA:
undetectable
1kqbD-3kzwA:
undetectable		 1kqbC-3kzwA:
17.97
1kqbD-3kzwA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 GLU A 132
GLY A 128
THR A 135
PHE A  95
 None
 1.08A 1kqbC-3kzwA:
undetectable
1kqbD-3kzwA:
undetectable		 1kqbC-3kzwA:
17.97
1kqbD-3kzwA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 PHE A 113
LEU A 108
MET A   1
 None
 0.83A 1mx1D-3kzwA:
2.7		 1mx1D-3kzwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 PHE A 444
ALA A 441
LEU A 348
LEU A 225
PHE A 448
 None
 1.24A 1og5A-3kzwA:
undetectable		 1og5A-3kzwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 SER A 297
VAL A 485
ILE A 481
ILE A 176
ILE A 129
 None
 1.01A 1qhsA-3kzwA:
undetectable		 1qhsA-3kzwA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 SER A 297
VAL A 485
ILE A 481
ILE A 176
ILE A 129
 None
 1.05A 1qhyA-3kzwA:
undetectable		 1qhyA-3kzwA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		6 / 12 LEU A 488
ILE A 484
ILE A 481
ARG A 133
LEU A 256
LEU A 301
 None
 1.45A 1xdkF-3kzwA:
undetectable		 1xdkF-3kzwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 GLY A 128
CYH A 127
LEU A 155
MET A 110
LEU A  88
 None
 1.18A 1zgyA-3kzwA:
undetectable		 1zgyA-3kzwA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 PHE A   3
ALA A 126
MET A 110
LEU A 155
LEU A   5
 None
 0.94A 2hw2A-3kzwA:
undetectable		 2hw2A-3kzwA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 11 THR A 446
VAL A 362
LEU A 256
ILE A 484
ALA A 384
 None
 1.23A 2zbzA-3kzwA:
undetectable		 2zbzA-3kzwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 ALA A 295
ALA A 463
GLY A 478
THR A 477
LEU A 178
 None
 1.21A 2zifB-3kzwA:
undetectable		 2zifB-3kzwA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 TYR A 358
GLU A 221
ASP A 216
 CL  A 496 ( 4.3A)
None
None
 0.78A 3bxoA-3kzwA:
undetectable		 3bxoA-3kzwA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 TYR A 358
GLU A 221
ASP A 216
 CL  A 496 ( 4.3A)
None
None
 0.79A 3bxoB-3kzwA:
undetectable		 3bxoB-3kzwA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 MET A 283
MET A 480
PHE A 182
 None
 1.34A 3gn8A-3kzwA:
undetectable		 3gn8A-3kzwA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 9 GLY A 285
ALA A 286
GLY A 291
ILE A 292
LEU A 309
 None
 0.92A 3ogpA-3kzwA:
undetectable		 3ogpA-3kzwA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 ILE A  20
PHE A  62
SER A 112
LEU A 109
ILE A  37
 None
 1.13A 3qfxA-3kzwA:
undetectable		 3qfxA-3kzwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 ILE A  20
PHE A  62
SER A 112
LEU A 109
ILE A  37
 None
 1.14A 3qfxB-3kzwA:
undetectable		 3qfxB-3kzwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 GLY A 285
ALA A 286
ILE A 199
GLY A 291
ILE A 292
 None
 1.02A 3ucbA-3kzwA:
undetectable		 3ucbA-3kzwA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 TYR A 354
ASP A 211
ASP A 214
 None
 0.79A 4a6eA-3kzwA:
undetectable		 4a6eA-3kzwA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 GLN A 486
ASP A 122
GLN A 119
 None
 0.93A 4aztA-3kzwA:
undetectable		 4aztA-3kzwA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 11 SER A 159
PHE A  32
ILE A 156
ASN A   6
HIS A  34
 None
 1.47A 4bb2A-3kzwA:
undetectable
4bb2B-3kzwA:
undetectable		 4bb2A-3kzwA:
22.29
4bb2B-3kzwA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 11 LEU A  71
LEU A  16
ILE A  72
LEU A  24
ILE A  37
 None
 1.20A 4dm8A-3kzwA:
undetectable		 4dm8A-3kzwA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 PHE A  95
GLY A 173
LEU A 178
ALA A 295
ILE A 481
 None
 1.06A 4krhB-3kzwA:
undetectable		 4krhB-3kzwA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 MET A 480
ASN A 288
GLY A 291
LEU A 488
ILE A 459
 None
 1.47A 4p6xA-3kzwA:
undetectable		 4p6xA-3kzwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 ALA A 287
GLY A 258
GLY A 291
VAL A 240
ILE A 242
 None
 0.96A 4q5mA-3kzwA:
undetectable		 4q5mA-3kzwA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 LEU A  88
ASP A 404
TYR A  84
 None
 0.66A 4qc6B-3kzwA:
1.5		 4qc6B-3kzwA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 7 HIS A 431
LYS A 437
GLY A 434
ASN A 433
 None
 1.34A 5a5zC-3kzwA:
undetectable		 5a5zC-3kzwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 TYR A  58
THR A  60
THR A  73
 None
 0.66A 5aoxB-3kzwA:
undetectable		 5aoxB-3kzwA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 TYR A  58
THR A  60
THR A  73
 None
 0.73A 5aoxE-3kzwA:
undetectable		 5aoxE-3kzwA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 9 GLN A 130
GLY A 173
SER A 171
ILE A 481
ALA A 179
 None
 1.31A 5entC-3kzwA:
undetectable		 5entC-3kzwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 ALA A 287
VAL A 289
PHE A 195
ILE A 242
 None
 1.00A 5of1A-3kzwA:
undetectable		 5of1A-3kzwA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 9 VAL A 210
ALA A 196
PHE A 195
VAL A 290
ILE A 242
 None
 1.12A 5om2A-3kzwA:
undetectable
5om2B-3kzwA:
undetectable		 5om2A-3kzwA:
10.98
5om2B-3kzwA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 ILE A 129
ILE A  17
LEU A 153
PHE A   3
 None
 1.03A 5vkqB-3kzwA:
undetectable
5vkqC-3kzwA:
undetectable		 5vkqB-3kzwA:
15.19
5vkqC-3kzwA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 6 ILE A 129
ILE A  17
LEU A 153
PHE A   3
 None
 1.02A 5vkqC-3kzwA:
undetectable
5vkqD-3kzwA:
undetectable		 5vkqC-3kzwA:
15.19
5vkqD-3kzwA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 GLN A  85
SER A  83
ILE A  90
TYR A  58
ASP A 118
 None
 1.49A 5vlmA-3kzwA:
1.4		 5vlmA-3kzwA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		4 / 8 ILE A 374
PRO A 476
THR A 464
PRO A 462
 None
None
NA  A 498 (-3.9A)
None
 1.12A 5x23A-3kzwA:
undetectable		 5x23A-3kzwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3kzw CYTOSOL
AMINOPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 TYR A 107
ASN A  33
LEU A   9
 None
 0.83A 6b58A-3kzwA:
undetectable		 6b58A-3kzwA:
22.17