SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 12 PRO A 155
ILE A 180
ALA A 175
PRO A   4
ALA A   6
 None
 1.11A 1sg9C-3kzxA:
2.6		 1sg9C-3kzxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		3 / 3 GLY A  86
GLU A  89
ASN A 196
 None
 0.68A 1zq9A-3kzxA:
undetectable		 1zq9A-3kzxA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		4 / 4 ILE A 103
ASP A  79
LEU A  83
ARG A 113
 None
 1.33A 2a7qA-3kzxA:
undetectable		 2a7qA-3kzxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 8 ILE A 180
LEU A 192
PHE A 194
ARG A 201
LEU A 207
 None
 1.36A 2einA-3kzxA:
undetectable
2einJ-3kzxA:
undetectable		 2einA-3kzxA:
17.44
2einJ-3kzxA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		4 / 5 THR A  14
SER A 165
ASP A 164
SER A 167
 None
 1.40A 2hdnA-3kzxA:
undetectable
2hdnB-3kzxA:
undetectable
2hdnD-3kzxA:
2.7		 2hdnA-3kzxA:
8.56
2hdnB-3kzxA:
21.53
2hdnD-3kzxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 12 PHE A 203
ILE A 204
LEU A  94
LEU A 192
PHE A   9
 None
 1.14A 2jn3A-3kzxA:
undetectable		 2jn3A-3kzxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		4 / 6 LEU A  94
LEU A  91
ILE A 204
ARG A 201
 None
 0.89A 2rlfA-3kzxA:
undetectable
2rlfB-3kzxA:
undetectable		 2rlfA-3kzxA:
23.96
2rlfB-3kzxA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		4 / 6 LEU A  94
LEU A  91
ILE A 204
ARG A 201
 None
 0.86A 2rlfC-3kzxA:
undetectable
2rlfD-3kzxA:
undetectable		 2rlfC-3kzxA:
23.96
2rlfD-3kzxA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 8 ILE A 180
LEU A 192
PHE A 194
ARG A 201
LEU A 207
 None
 1.34A 3abkA-3kzxA:
undetectable
3abkJ-3kzxA:
undetectable		 3abkA-3kzxA:
17.44
3abkJ-3kzxA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 8 ILE A 180
LEU A 192
PHE A 194
ARG A 201
LEU A 207
 None
 1.30A 3abmN-3kzxA:
undetectable
3abmW-3kzxA:
undetectable		 3abmN-3kzxA:
17.44
3abmW-3kzxA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 8 ILE A 180
LEU A 192
PHE A 194
ARG A 201
LEU A 207
 None
 1.32A 3asoN-3kzxA:
undetectable
3asoW-3kzxA:
undetectable		 3asoN-3kzxA:
17.44
3asoW-3kzxA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 12 VAL A   7
GLY A  86
ALA A  87
LEU A  91
LEU A  94
 None
 0.88A 3n8yB-3kzxA:
undetectable		 3n8yB-3kzxA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 10 GLY A 176
ALA A 175
ILE A 169
VAL A 104
VAL A 144
 None
 1.05A 3nu9B-3kzxA:
undetectable		 3nu9B-3kzxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 12 LEU A 121
LEU A  90
PHE A   9
TYR A 124
ASP A  10
 None
 1.47A 4j7xJ-3kzxA:
4.1		 4j7xJ-3kzxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 12 ALA A   6
LEU A 207
GLY A 163
LEU A 192
PHE A 194
 None
 1.25A 4kykA-3kzxA:
undetectable
4kykB-3kzxA:
undetectable		 4kykA-3kzxA:
24.48
4kykB-3kzxA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 11 TYR A  36
TYR A  28
TYR A  68
LEU A  57
LEU A  56
 None
 1.40A 4m7tA-3kzxA:
undetectable		 4m7tA-3kzxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		4 / 8 ASP A 168
ASP A 164
ASP A  10
TYR A  68
 None
 1.04A 5cfsA-3kzxA:
undetectable		 5cfsA-3kzxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 12 ILE A 162
LEU A  15
PHE A 197
ARG A 201
ASN A 202
 None
 1.05A 5k7uA-3kzxA:
undetectable		 5k7uA-3kzxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 8 ILE A 180
LEU A 192
PHE A 194
ARG A 201
LEU A 207
 None
 1.38A 5zcpN-3kzxA:
undetectable
5zcpW-3kzxA:
undetectable		 5zcpN-3kzxA:
17.44
5zcpW-3kzxA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1
(Ehrlichia
chaffeensis) 		5 / 9 LEU A  15
THR A  14
ILE A 162
PHE A 161
VAL A   7
 None
 1.27A 6ef6A-3kzxA:
undetectable		 6ef6A-3kzxA:
19.83