SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3kzz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3kzz SNAP-TAG
(Homo
sapiens) 		4 / 5 LEU A 142
PRO A 138
VAL A 139
ILE A 143
 None
 0.80A 2aoiB-3kzzA:
undetectable		 2aoiB-3kzzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3kzz SNAP-TAG
(Homo
sapiens) 		5 / 12 LEU A 168
GLU A 159
ALA A 145
VAL A 148
GLY A 156
 None
OBG  A 181 (-3.7A)
OBG  A 181 (-3.4A)
OBG  A 181 (-4.3A)
None
 1.14A 4hfpD-3kzzA:
undetectable		 4hfpD-3kzzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3kzz SNAP-TAG
(Homo
sapiens) 		5 / 12 TYR A  69
ASN A 137
LEU A 102
LEU A 168
PHE A  33
 None
 1.44A 4rtbA-3kzzA:
undetectable		 4rtbA-3kzzA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3kzz SNAP-TAG
(Homo
sapiens) 		5 / 12 GLY A 177
LEU A 168
VAL A 164
ALA A 163
LEU A 162
 None
 0.95A 5kpcA-3kzzA:
undetectable		 5kpcA-3kzzA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3kzz SNAP-TAG
(Homo
sapiens) 		5 / 10 ILE A  32
GLY A  17
GLY A  35
LEU A  21
SER A  22
 None
 1.12A 5twjB-3kzzA:
undetectable		 5twjB-3kzzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3kzz SNAP-TAG
(Homo
sapiens) 		4 / 7 LEU A 117
ALA A 121
GLN A  97
GLN A 150
 None
 1.01A 6b89A-3kzzA:
undetectable		 6b89A-3kzzA:
16.67