SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l01'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 7 ILE A 366
GLY A 362
PHE A 216
ASN A 217
 None
 0.91A 1oniG-3l01A:
undetectable
1oniI-3l01A:
undetectable		 1oniG-3l01A:
15.50
1oniI-3l01A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		3 / 3 VAL A 101
ALA A 100
HIS A 130
 None
None
GOL  A6502 ( 3.8A)
 0.72A 1q23C-3l01A:
undetectable		 1q23C-3l01A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		3 / 3 VAL A 101
ALA A 100
HIS A 130
 None
None
GOL  A6502 ( 3.8A)
 0.67A 1q23H-3l01A:
undetectable		 1q23H-3l01A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 PHE A 286
LEU A 303
PHE A 281
VAL A 310
ALA A 271
 None
 1.19A 1q23H-3l01A:
undetectable
1q23I-3l01A:
undetectable		 1q23H-3l01A:
18.25
1q23I-3l01A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		3 / 3 VAL A 101
ALA A 100
HIS A 130
 None
None
GOL  A6502 ( 3.8A)
 0.78A 1q23L-3l01A:
undetectable		 1q23L-3l01A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		3 / 3 VAL A 101
ALA A 100
HIS A 130
 None
None
GOL  A6502 ( 3.8A)
 0.69A 1q23J-3l01A:
undetectable		 1q23J-3l01A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 8 LEU A 374
ALA A 345
ILE A 334
GLY A 362
PHE A 412
 None
 1.39A 1sv9A-3l01A:
undetectable		 1sv9A-3l01A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 7 ILE A 287
PHE A 321
LEU A 317
LYS A 311
 None
 0.82A 1yc2E-3l01A:
5.4		 1yc2E-3l01A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 10 LEU A 374
ALA A 345
ILE A 334
GLY A 362
PHE A 412
 None
 1.38A 2b17A-3l01A:
undetectable		 2b17A-3l01A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 9 VAL A  56
VAL A  63
GLY A  80
GLY A  81
ALA A 106
 None
 0.96A 2z0yA-3l01A:
4.1		 2z0yA-3l01A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 9 VAL A  56
VAL A  63
GLY A  80
GLY A  81
ALA A 106
 None
 0.92A 2z0yB-3l01A:
3.9		 2z0yB-3l01A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 342
ALA A 345
PHE A 412
SER A 411
GLU A  20
 K  A5600 (-4.4A)
None
None
None
None
 1.31A 3s8pA-3l01A:
undetectable		 3s8pA-3l01A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 342
ALA A 345
PHE A 412
SER A 411
GLU A  20
 K  A5600 (-4.4A)
None
None
None
None
 1.32A 3s8pB-3l01A:
undetectable		 3s8pB-3l01A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 5 LEU A 171
ALA A 166
THR A 182
PHE A 133
 MTT  A5360 (-4.0A)
None
MTT  A5360 (-2.9A)
None
 1.22A 3vasB-3l01A:
3.0		 3vasB-3l01A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 275
LEU A 268
ILE A 387
PHE A 254
TYR A 337
 None
 1.44A 4a79A-3l01A:
undetectable		 4a79A-3l01A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 275
LEU A 268
ILE A 387
PHE A 254
TYR A 337
 None
 1.38A 4a79B-3l01A:
undetectable		 4a79B-3l01A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 11 LEU A 275
LEU A 268
ILE A 387
PHE A 254
TYR A 337
 None
 1.44A 4a7aA-3l01A:
undetectable		 4a7aA-3l01A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 342
ALA A 345
PHE A 412
SER A 411
GLU A  20
 K  A5600 (-4.4A)
None
None
None
None
 1.36A 4bupB-3l01A:
undetectable		 4bupB-3l01A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 ALA A 134
ILE A  78
PHE A  39
LEU A 114
THR A 131
 None
 1.24A 4cd2A-3l01A:
undetectable		 4cd2A-3l01A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 8 LEU A  29
VAL A 123
TYR A 421
LEU A   5
 None
 0.92A 4q0bA-3l01A:
undetectable		 4q0bA-3l01A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 8 LEU A   6
THR A  40
PRO A  41
LEU A  22
 None
 1.09A 4qknA-3l01A:
undetectable		 4qknA-3l01A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		6 / 12 ILE A 138
GLY A 135
PHE A 142
HIS A 125
VAL A 124
ILE A 144
 None
 1.20A 4rvdA-3l01A:
undetectable		 4rvdA-3l01A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 ILE A 138
GLY A 135
PHE A 142
VAL A 124
ILE A 144
 None
 1.02A 4rvgA-3l01A:
3.2		 4rvgA-3l01A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 7 THR A 102
GLY A 104
ALA A 106
ILE A  78
 None
 0.84A 4txnA-3l01A:
2.4		 4txnA-3l01A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 7 THR A 102
GLY A 104
ALA A 106
ILE A  78
 None
 0.82A 4txnB-3l01A:
2.1		 4txnB-3l01A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 7 THR A 102
GLY A 104
ALA A 106
ILE A  78
 None
 0.84A 4txnC-3l01A:
2.0		 4txnC-3l01A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 7 THR A 102
GLY A 104
ALA A 106
ILE A  78
 None
 0.81A 4txnD-3l01A:
2.1		 4txnD-3l01A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 4 GLY A 256
VAL A 265
PHE A 252
ILE A 333
 None
 1.14A 4xv2B-3l01A:
undetectable		 4xv2B-3l01A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		3 / 3 GLY A   7
LEU A  22
HIS A 127
 None
 0.70A 5u63A-3l01A:
3.4		 5u63A-3l01A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		3 / 3 GLY A   7
LEU A  22
HIS A 127
 None
 0.68A 5u63B-3l01A:
undetectable		 5u63B-3l01A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		6 / 10 HIS A 151
VAL A 193
ASN A 217
GLU A 339
PRO A 340
GLY A 342
 None
None
None
K  A5600 (-4.0A)
K  A5600 ( 4.8A)
K  A5600 (-4.4A)
 0.77A 5vncC-3l01A:
23.7		 5vncC-3l01A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		6 / 10 VAL A 193
ASN A 217
LYS A 263
GLU A 339
PRO A 340
GLY A 342
 None
None
None
K  A5600 (-4.0A)
K  A5600 ( 4.8A)
K  A5600 (-4.4A)
 0.88A 5vncC-3l01A:
23.7		 5vncC-3l01A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 10 PRO A 340
ALA A 357
GLY A 372
THR A 371
ALA A 345
 K  A5600 ( 4.8A)
None
None
None
None
 1.30A 5vyhA-3l01A:
undetectable		 5vyhA-3l01A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 10 PRO A 380
ALA A 357
GLY A 372
ILE A 367
ALA A 359
 None
 1.33A 5vyhA-3l01A:
undetectable		 5vyhA-3l01A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 342
ALA A 345
PHE A 412
SER A 411
GLU A  20
 K  A5600 (-4.4A)
None
None
None
None
 1.31A 5wbvA-3l01A:
undetectable		 5wbvA-3l01A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A 342
ALA A 345
PHE A 412
SER A 411
GLU A  20
 K  A5600 (-4.4A)
None
None
None
None
 1.32A 5wbvB-3l01A:
0.0		 5wbvB-3l01A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 THR A 149
ILE A 150
LEU A 346
PHE A 205
LEU A 363
 None
 1.34A 6a93A-3l01A:
undetectable		 6a93A-3l01A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		3 / 3 ARG A 285
GLY A 249
GLU A 248
 None
 0.53A 6fgdA-3l01A:
2.5		 6fgdA-3l01A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A  16
ASP A 128
VAL A 193
ASN A 217
PRO A 340
 CL  A5703 ( 3.9A)
GOL  A6500 (-3.2A)
None
None
K  A5600 ( 4.8A)
 0.78A 6gneA-3l01A:
35.2		 6gneA-3l01A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A  16
GLY A  17
ASP A 128
ASN A 217
PRO A 340
 CL  A5703 ( 3.9A)
CL  A5703 (-4.7A)
GOL  A6500 (-3.2A)
None
K  A5600 ( 4.8A)
 0.88A 6gneA-3l01A:
35.2		 6gneA-3l01A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A  17
ASP A 128
VAL A 193
ASN A 217
PRO A 340
 CL  A5703 (-4.7A)
GOL  A6500 (-3.2A)
None
None
K  A5600 ( 4.8A)
 0.59A 6gneA-3l01A:
35.2		 6gneA-3l01A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A  17
VAL A 193
ASN A 217
PRO A 340
GLY A 342
 CL  A5703 (-4.7A)
None
None
K  A5600 ( 4.8A)
K  A5600 (-4.4A)
 1.03A 6gneA-3l01A:
35.2		 6gneA-3l01A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 6 TYR A  89
TRP A 129
HIS A 151
GLU A 339
 GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
K  A5600 (-4.0A)
 0.53A 6gneA-3l01A:
35.2		 6gneA-3l01A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		6 / 12 GLU A   9
GLY A  16
ASP A 128
VAL A 193
ASN A 217
PRO A 340
 None
CL  A5703 ( 3.9A)
GOL  A6500 (-3.2A)
None
None
K  A5600 ( 4.8A)
 0.78A 6gneB-3l01A:
35.0		 6gneB-3l01A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		6 / 12 GLU A   9
GLY A  16
GLY A  17
ASP A 128
ASN A 217
PRO A 340
 None
CL  A5703 ( 3.9A)
CL  A5703 (-4.7A)
GOL  A6500 (-3.2A)
None
K  A5600 ( 4.8A)
 0.90A 6gneB-3l01A:
35.0		 6gneB-3l01A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		6 / 12 GLU A   9
GLY A  17
ASP A 128
VAL A 193
ASN A 217
PRO A 340
 None
CL  A5703 (-4.7A)
GOL  A6500 (-3.2A)
None
None
K  A5600 ( 4.8A)
 0.72A 6gneB-3l01A:
35.0		 6gneB-3l01A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A  17
VAL A 193
ASN A 217
PRO A 340
GLY A 342
 CL  A5703 (-4.7A)
None
None
K  A5600 ( 4.8A)
K  A5600 (-4.4A)
 1.02A 6gneB-3l01A:
35.0		 6gneB-3l01A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 8 TYR A  89
TRP A 129
HIS A 151
GLU A 339
 GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
K  A5600 (-4.0A)
 0.52A 6gneB-3l01A:
34.9		 6gneB-3l01A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		4 / 8 VAL A  15
TYR A  89
TRP A 129
HIS A 151
 None
GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
 0.57A 6gneB-3l01A:
34.9		 6gneB-3l01A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 ASP A 128
HIS A 130
ASN A 217
GLU A 339
PRO A 340
 GOL  A6500 (-3.2A)
GOL  A6502 ( 3.8A)
None
K  A5600 (-4.0A)
K  A5600 ( 4.8A)
 0.73A 6gnfA-3l01A:
33.9		 6gnfA-3l01A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 9 GLY A  16
GLY A  17
TYR A  89
TRP A 129
HIS A 151
 CL  A5703 ( 3.9A)
CL  A5703 (-4.7A)
GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
 0.88A 6gnfA-3l01A:
33.9		 6gnfA-3l01A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 9 GLY A  16
TYR A  89
TRP A 129
HIS A 151
VAL A 193
 CL  A5703 ( 3.9A)
GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
None
 0.79A 6gnfA-3l01A:
33.9		 6gnfA-3l01A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 9 GLY A  17
TYR A  89
TRP A 129
HIS A 151
VAL A 193
 CL  A5703 (-4.7A)
GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
None
 0.70A 6gnfA-3l01A:
33.9		 6gnfA-3l01A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 10 GLY A  17
LEU A  18
TYR A  89
TRP A 129
HIS A 151
 CL  A5703 (-4.7A)
GOL  A6500 ( 4.3A)
GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
 0.85A 6gnfC-3l01A:
34.5		 6gnfC-3l01A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 10 LEU A  18
TYR A  89
TRP A 129
HIS A 151
VAL A 193
 GOL  A6500 ( 4.3A)
GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
None
 0.56A 6gnfC-3l01A:
34.5		 6gnfC-3l01A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 ASP A 128
ASN A 217
GLU A 339
PRO A 340
GLY A 342
 GOL  A6500 (-3.2A)
None
K  A5600 (-4.0A)
K  A5600 ( 4.8A)
K  A5600 (-4.4A)
 0.99A 6gnfC-3l01A:
34.5		 6gnfC-3l01A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 ASP A 128
HIS A 130
ASN A 217
GLU A 339
PRO A 340
 GOL  A6500 (-3.2A)
GOL  A6502 ( 3.8A)
None
K  A5600 (-4.0A)
K  A5600 ( 4.8A)
 0.73A 6gnfC-3l01A:
34.5		 6gnfC-3l01A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A  16
LEU A  18
ASP A 128
HIS A 130
ASN A 217
 CL  A5703 ( 3.9A)
GOL  A6500 ( 4.3A)
GOL  A6500 (-3.2A)
GOL  A6502 ( 3.8A)
None
 0.99A 6gngA-3l01A:
34.6		 6gngA-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLY A  17
LEU A  18
ASP A 128
HIS A 130
ASN A 217
 CL  A5703 (-4.7A)
GOL  A6500 ( 4.3A)
GOL  A6500 (-3.2A)
GOL  A6502 ( 3.8A)
None
 0.93A 6gngA-3l01A:
34.6		 6gngA-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		6 / 12 GLU A   9
GLY A  17
TYR A  89
TRP A 129
HIS A 151
PRO A 340
 None
CL  A5703 (-4.7A)
GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
K  A5600 ( 4.8A)
 0.85A 6gngA-3l01A:
34.6		 6gngA-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		7 / 12 GLU A   9
TYR A  89
TRP A 129
HIS A 151
VAL A 193
GLU A 339
PRO A 340
 None
GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
None
K  A5600 (-4.0A)
K  A5600 ( 4.8A)
 0.74A 6gngA-3l01A:
34.6		 6gngA-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		7 / 12 TYR A  89
TRP A 129
HIS A 151
VAL A 193
GLU A 339
PRO A 340
GLY A 342
 GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
None
K  A5600 (-4.0A)
K  A5600 ( 4.8A)
K  A5600 (-4.4A)
 0.93A 6gngA-3l01A:
34.6		 6gngA-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		6 / 12 TYR A  89
TRP A 129
HIS A 151
VAL A 193
GLU A 339
GLY A 342
 GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
None
K  A5600 (-4.0A)
K  A5600 (-4.4A)
 0.83A 6gngB-3l01A:
34.6		 6gngB-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		6 / 12 GLU A   9
GLY A  16
GLY A  17
LEU A  18
HIS A 130
PRO A 340
 None
CL  A5703 ( 3.9A)
CL  A5703 (-4.7A)
GOL  A6500 ( 4.3A)
GOL  A6502 ( 3.8A)
K  A5600 ( 4.8A)
 0.84A 6gngB-3l01A:
34.5		 6gngB-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 3l01 GLGA GLYCOGEN
SYNTHASE
(Pyrococcus
abyssi) 		5 / 12 GLU A   9
GLY A  17
LEU A  18
HIS A 130
PRO A 340
 None
CL  A5703 (-4.7A)
GOL  A6500 ( 4.3A)
GOL  A6502 ( 3.8A)
K  A5600 ( 4.8A)
 0.85A 6gngB-3l01A:
34.5		 6gngB-3l01A:
26.28