SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l07'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		5 / 12 ILE A 231
GLY A 260
VAL A 257
ASP A 228
SER A  10
 IMD  A 503 ( 4.6A)
None
None
None
None
 1.20A 1nbhC-3l07A:
undetectable		 1nbhC-3l07A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		3 / 3 THR A 265
PRO A 263
THR A 267
 None
IMD  A 503 (-4.3A)
None
 0.79A 209dC-3l07A:
undetectable		 209dC-3l07A:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		4 / 6 TYR A 271
THR A 147
GLU A 268
GLU A 151
 EDO  A 506 (-3.5A)
EDO  A 506 ( 3.5A)
EDO  A 506 (-2.8A)
None
 1.35A 2dttB-3l07A:
undetectable
2dttC-3l07A:
undetectable		 2dttB-3l07A:
18.79
2dttC-3l07A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		4 / 5 PRO A 258
VAL A 257
THR A 147
GLY A 144
 IMD  A 503 (-4.4A)
None
EDO  A 506 ( 3.5A)
None
 1.16A 3elzB-3l07A:
undetectable		 3elzB-3l07A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		4 / 8 LEU A   3
GLY A 262
PRO A 263
MET A 264
 None
IMD  A 503 ( 3.8A)
IMD  A 503 (-4.3A)
None
 1.06A 3hcrA-3l07A:
2.3		 3hcrA-3l07A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		4 / 6 PRO A  32
LEU A  34
LEU A  17
LEU A 270
 None
 1.11A 3q1eA-3l07A:
undetectable
3q1eC-3l07A:
undetectable		 3q1eA-3l07A:
17.87
3q1eC-3l07A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		5 / 9 ASP A 228
ILE A 227
VAL A 261
GLY A   6
ILE A 154
 None
 0.82A 3s43A-3l07A:
undetectable		 3s43A-3l07A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		4 / 6 CYH A 140
THR A 141
GLY A 120
ASP A 119
 None
None
None
EDO  A 507 (-3.9A)
 1.25A 3w9tE-3l07A:
undetectable		 3w9tE-3l07A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		5 / 12 LEU A  77
LEU A  80
LEU A  84
ILE A 112
ILE A  37
 None
 1.03A 4a7aB-3l07A:
undetectable		 4a7aB-3l07A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		4 / 4 LYS A 116
LEU A 280
ALA A  92
VAL A  35
 None
 1.11A 4ik6A-3l07A:
undetectable		 4ik6A-3l07A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		4 / 5 ASN A 232
PRO A 212
GLY A 210
ASP A 228
 None
 1.12A 4n48B-3l07A:
4.4		 4n48B-3l07A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		4 / 5 SER A 167
ALA A 166
GLN A 176
THR A 187
 None
PO4  A 501 (-3.7A)
None
None
 1.33A 5n0tA-3l07A:
2.3		 5n0tA-3l07A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		4 / 4 SER A 167
ALA A 166
GLN A 176
THR A 187
 None
PO4  A 501 (-3.7A)
None
None
 1.27A 5n0xA-3l07A:
undetectable		 5n0xA-3l07A:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		7 / 12 GLN A  96
LEU A  97
PRO A  98
ASP A 119
THR A 141
VAL A 170
THR A 265
 None
EDO  A 507 ( 4.7A)
None
EDO  A 507 (-3.9A)
None
None
None
 0.63A 6debB-3l07A:
42.2		 6debB-3l07A:
50.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		6 / 12 GLN A  96
LEU A  97
PRO A  98
LYS A 105
ASP A 119
THR A 265
 None
EDO  A 507 ( 4.7A)
None
None
EDO  A 507 (-3.9A)
None
 0.50A 6debB-3l07A:
42.2		 6debB-3l07A:
50.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		5 / 12 GLN A  96
PRO A  98
LYS A 105
PHE A 121
THR A 265
 None
None
None
EDO  A 507 (-4.9A)
None
 0.99A 6debB-3l07A:
42.2		 6debB-3l07A:
50.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		6 / 12 GLN A  96
PRO A  98
PHE A 121
THR A 141
VAL A 170
THR A 265
 None
None
EDO  A 507 (-4.9A)
None
None
None
 0.82A 6debB-3l07A:
42.2		 6debB-3l07A:
50.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		7 / 12 LEU A  94
GLN A  96
LEU A  97
PRO A  98
ASP A 119
THR A 141
THR A 265
 EDO  A 507 (-4.6A)
None
EDO  A 507 ( 4.7A)
None
EDO  A 507 (-3.9A)
None
None
 0.54A 6debB-3l07A:
42.2		 6debB-3l07A:
50.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		6 / 12 LEU A  94
GLN A  96
LEU A  97
PRO A  98
ASP A 119
THR A 265
 EDO  A 507 (-4.6A)
None
EDO  A 507 ( 4.7A)
None
EDO  A 507 (-3.9A)
None
 0.85A 6debB-3l07A:
42.2		 6debB-3l07A:
50.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		5 / 12 LEU A  97
PRO A  98
LYS A 105
ASP A 119
THR A 141
 EDO  A 507 ( 4.7A)
None
None
EDO  A 507 (-3.9A)
None
 1.00A 6debB-3l07A:
42.2		 6debB-3l07A:
50.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		6 / 12 PRO A  98
PHE A 121
THR A 141
SER A 167
VAL A 170
THR A 265
 None
EDO  A 507 (-4.9A)
None
None
None
None
 0.86A 6debB-3l07A:
42.2		 6debB-3l07A:
50.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		5 / 5 TYR A  48
LYS A  52
GLN A  96
GLY A 210
ILE A 231
 None
None
None
None
IMD  A 503 ( 4.6A)
 0.75A 6debB-3l07A:
42.2		 6debB-3l07A:
50.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		5 / 10 SER A  45
LEU A  77
ASP A 119
ILE A 103
PRO A 100
 None
None
EDO  A 507 (-3.9A)
None
None
 1.50A 6dlzB-3l07A:
3.7
6dlzC-3l07A:
3.6		 6dlzB-3l07A:
14.75
6dlzC-3l07A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3l07 BIFUNCTIONAL PROTEIN
FOLD
(Francisella
tularensis) 		5 / 10 SER A  45
LEU A  77
ASP A 119
ILE A 103
PRO A 100
 None
None
EDO  A 507 (-3.9A)
None
None
 1.50A 6dm1B-3l07A:
2.9
6dm1C-3l07A:
3.6		 6dm1B-3l07A:
14.75
6dm1C-3l07A:
14.75