SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l09'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		6 / 12 GLY A  55
LEU A  56
LEU A  23
VAL A  26
LEU A 208
PHE A  50
 None
 1.44A 1gseB-3l09A:
2.8		 1gseB-3l09A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		5 / 10 LEU A  11
ALA A  14
GLU A  18
LEU A  21
ARG A 215
 None
None
None
SO4  A 266 (-4.6A)
SO4  A 266 (-4.1A)
 1.39A 1pcgB-3l09A:
undetectable		 1pcgB-3l09A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		5 / 10 LEU A  11
ALA A  14
GLU A  18
LEU A  21
ARG A 215
 None
None
None
SO4  A 266 (-4.6A)
SO4  A 266 (-4.1A)
 1.47A 1qktA-3l09A:
undetectable		 1qktA-3l09A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		5 / 12 ARG A 101
ALA A 184
ALA A 233
ARG A 232
GLU A 225
 None
 1.18A 2j0dA-3l09A:
undetectable		 2j0dA-3l09A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		5 / 12 ALA A 107
GLY A 146
ILE A 137
ALA A 227
LEU A 165
 None
 1.09A 2plwA-3l09A:
undetectable		 2plwA-3l09A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		4 / 5 LEU A 128
PRO A 129
LEU A 132
ILE A 144
 None
 0.68A 2qd4A-3l09A:
undetectable		 2qd4A-3l09A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		5 / 12 GLY A 230
GLY A 229
PRO A 109
ALA A 110
ALA A 233
 None
 1.00A 3jb2A-3l09A:
undetectable		 3jb2A-3l09A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		4 / 7 LEU A  23
LEU A  47
HIS A 211
SER A  35
 None
None
SO4  A 266 (-3.5A)
None
 0.94A 3r9vA-3l09A:
undetectable
3r9vB-3l09A:
undetectable		 3r9vA-3l09A:
21.90
3r9vB-3l09A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		4 / 8 LEU A 143
ALA A 224
SER A 221
SER A 133
 None
 0.93A 3rodA-3l09A:
undetectable		 3rodA-3l09A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		3 / 3 ARG A 140
TRP A 155
GLY A 116
 None
 0.91A 4e7cA-3l09A:
undetectable		 4e7cA-3l09A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		4 / 4 LEU A 128
PRO A 129
LEU A 132
ILE A 144
 None
 0.79A 4f4dB-3l09A:
undetectable		 4f4dB-3l09A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		5 / 10 LEU A  11
ALA A  14
GLU A  18
LEU A  21
ARG A 215
 None
None
None
SO4  A 266 (-4.6A)
SO4  A 266 (-4.1A)
 1.40A 5dxeB-3l09A:
undetectable		 5dxeB-3l09A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		5 / 12 PHE A 203
LEU A  47
ILE A 102
SER A  35
LEU A 245
 None
 1.06A 5h8tA-3l09A:
undetectable		 5h8tA-3l09A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		5 / 12 PHE A 203
LEU A  47
ILE A 102
SER A  35
LEU A 245
 None
 1.10A 5hbsA-3l09A:
undetectable		 5hbsA-3l09A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		4 / 6 VAL A 172
SER A 221
ARG A 219
ILE A 217
 None
 0.98A 5jw1B-3l09A:
undetectable		 5jw1B-3l09A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Jannaschia
sp.
CCS1) 		4 / 7 THR A 204
PHE A 203
SER A  48
SER A  49
 None
 0.96A 6jnhA-3l09A:
undetectable		 6jnhA-3l09A:
22.05