SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l0g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		5 / 12 ILE A  94
LEU A  13
ALA A  12
VAL A  63
LEU A 271
 None
 1.07A 1xdkA-3l0gA:
undetectable		 1xdkA-3l0gA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		6 / 12 LEU A  13
ILE A   8
GLY A  48
ILE A 102
ALA A  12
ILE A   9
 None
 1.23A 2rkfB-3l0gA:
undetectable		 2rkfB-3l0gA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		5 / 12 PHE A  56
VAL A  82
VAL A  63
VAL A  46
ILE A 269
 None
 1.23A 3dl9A-3l0gA:
undetectable		 3dl9A-3l0gA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 7 LEU A 211
ASP A 164
SER A 236
THR A 129
 None
None
EDO  A 300 ( 4.6A)
EDO  A 300 (-4.2A)
 1.39A 3dzgB-3l0gA:
2.2		 3dzgB-3l0gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		5 / 12 ILE A  94
LEU A  13
ALA A  12
VAL A  63
LEU A 271
 None
 1.05A 3dzyA-3l0gA:
undetectable		 3dzyA-3l0gA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		3 / 3 LYS A 163
ILE A 260
PHE A 264
 FMT  A 301 (-3.3A)
None
None
 0.75A 3j7zS-3l0gA:
undetectable
3j7za-3l0gA:
undetectable		 3j7zS-3l0gA:
16.50
3j7za-3l0gA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 6 LEU A 211
GLU A 192
SER A 236
THR A 129
 None
None
EDO  A 300 ( 4.6A)
EDO  A 300 (-4.2A)
 1.49A 3ropA-3l0gA:
undetectable		 3ropA-3l0gA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		5 / 10 ALA A  86
GLY A  84
LEU A  52
ASN A  35
ILE A  38
 None
 0.96A 3wdmB-3l0gA:
undetectable		 3wdmB-3l0gA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		5 / 10 ALA A  86
GLY A  84
LEU A  52
ASN A  35
ILE A  38
 None
 1.04A 3wdmD-3l0gA:
undetectable		 3wdmD-3l0gA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		5 / 12 ASN A 266
PHE A 264
ILE A  38
GLY A  48
SER A 143
 None
 1.48A 4djfA-3l0gA:
6.5		 4djfA-3l0gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 7 VAL A 119
ILE A 126
ARG A 127
ILE A 257
 None
None
EDO  A 300 ( 4.5A)
None
 0.86A 4lv9A-3l0gA:
16.0		 4lv9A-3l0gA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 7 VAL A 119
ILE A 126
ARG A 127
ILE A 257
 None
None
EDO  A 300 ( 4.5A)
None
 0.90A 4lv9B-3l0gA:
16.3		 4lv9B-3l0gA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		5 / 11 ILE A  94
LEU A  13
ALA A  12
VAL A  63
LEU A 271
 None
 1.08A 4nqaA-3l0gA:
undetectable		 4nqaA-3l0gA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 4 ILE A 217
ASN A 243
ILE A 255
VAL A 235
 None
 1.23A 4uy87-3l0gA:
undetectable		 4uy87-3l0gA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 6 CYH A  47
ILE A 102
ILE A 108
ASP A 140
 None
 1.17A 4w5qA-3l0gA:
2.9		 4w5qA-3l0gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 6 CYH A  47
ILE A 102
ILE A 108
ASP A 140
 None
 1.21A 4w5tA-3l0gA:
2.3		 4w5tA-3l0gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 6 CYH A  47
ILE A 102
ILE A 108
ASP A 140
 None
 1.15A 4z4cA-3l0gA:
2.3		 4z4cA-3l0gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 6 CYH A  47
ILE A 102
ILE A 108
ASP A 140
 None
 1.16A 4z4dA-3l0gA:
3.1		 4z4dA-3l0gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 4 VAL A  82
ILE A  98
ASN A  57
VAL A  63
 None
 0.89A 5ajqA-3l0gA:
undetectable		 5ajqA-3l0gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		5 / 11 ILE A  94
LEU A  13
ALA A  12
VAL A  63
LEU A 271
 None
 1.01A 5ji0A-3l0gA:
undetectable		 5ji0A-3l0gA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 9 ILE A 111
VAL A 144
ASP A 117
ILE A 126
 None
 1.04A 5lg3I-3l0gA:
undetectable		 5lg3I-3l0gA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		5 / 12 ILE A  94
LEU A  13
ALA A  12
VAL A  63
LEU A 271
 None
 1.04A 5z12C-3l0gA:
undetectable		 5z12C-3l0gA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		4 / 6 CYH A  47
ILE A 102
ILE A 108
ASP A 140
 None
 1.15A 6cbdA-3l0gA:
2.9		 6cbdA-3l0gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Ehrlichia
chaffeensis) 		5 / 11 THR A 129
VAL A 144
PHE A 115
ILE A 247
VAL A 239
 EDO  A 300 (-4.2A)
None
None
None
None
 1.41A 6hcoA-3l0gA:
undetectable
6hcoB-3l0gA:
undetectable		 6hcoA-3l0gA:
19.30
6hcoB-3l0gA:
19.30