SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 12 GLY A 411
ALA A 412
GLY A 463
ILE A 405
ILE A 471
 None
 0.88A 1hxbA-3l0iA:
undetectable		 1hxbA-3l0iA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 3l0i DRRA
(Legionella
pneumophila) 		4 / 6 SER A 358
ASN A 355
LEU A 352
TRP A 353
 None
 1.17A 1mxdA-3l0iA:
undetectable		 1mxdA-3l0iA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 3l0i DRRA
(Legionella
pneumophila) 		4 / 8 SER A 358
ASN A 355
LEU A 352
TRP A 353
 None
 1.21A 1mxgA-3l0iA:
undetectable		 1mxgA-3l0iA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 12 LEU A 255
LEU A 252
ILE A 248
LEU A 335
LEU A 278
 None
 0.98A 1xdkF-3l0iA:
undetectable		 1xdkF-3l0iA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 12 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.12A 4eckB-3l0iA:
undetectable		 4eckB-3l0iA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 11 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.18A 4eilA-3l0iA:
undetectable		 4eilA-3l0iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 10 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.12A 4eilB-3l0iA:
undetectable		 4eilB-3l0iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 11 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.20A 4eilC-3l0iA:
undetectable		 4eilC-3l0iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 11 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.19A 4eilE-3l0iA:
undetectable		 4eilE-3l0iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 11 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.17A 4kyaA-3l0iA:
undetectable		 4kyaA-3l0iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 12 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.12A 4kyaB-3l0iA:
undetectable		 4kyaB-3l0iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 10 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.22A 4kyaC-3l0iA:
undetectable		 4kyaC-3l0iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 12 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.11A 4kyaD-3l0iA:
undetectable		 4kyaD-3l0iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 11 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.20A 4kyaE-3l0iA:
undetectable		 4kyaE-3l0iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 12 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.10A 4kyaF-3l0iA:
undetectable		 4kyaF-3l0iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3l0i DRRA
(Legionella
pneumophila) 		5 / 11 ALA A 419
ASP A 415
SER A 465
LEU A 504
VAL A 518
 None
 1.21A 4kyaG-3l0iA:
undetectable		 4kyaG-3l0iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3l0i DRRA
(Legionella
pneumophila) 		4 / 6 ILE A 471
GLY A 363
ASN A 364
ILE A 467
 None
 0.86A 5j4nB-3l0iA:
undetectable		 5j4nB-3l0iA:
22.17