SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l0o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		5 / 12 GLU A  12
ILE A   8
ARG A 208
ILE A 207
THR A 250
 None
 1.32A 1d1gA-3l0oA:
undetectable		 1d1gA-3l0oA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		5 / 12 PHE A 304
VAL A  61
ILE A 103
TYR A 128
LEU A 211
 None
 1.13A 1fm4A-3l0oA:
undetectable		 1fm4A-3l0oA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		3 / 3 THR A 144
THR A 311
PRO A 145
 None
 0.87A 1i3wG-3l0oA:
undetectable		 1i3wG-3l0oA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		3 / 3 GLU A 248
LYS A 242
VAL A 244
 None
SO4  A 432 (-3.2A)
None
 0.87A 1l2iA-3l0oA:
undetectable		 1l2iA-3l0oA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		3 / 3 THR A 311
PRO A 145
THR A 144
 None
 0.82A 1mnvD-3l0oA:
undetectable		 1mnvD-3l0oA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		3 / 3 THR A 311
PRO A 145
THR A 144
 None
 0.88A 1ovfB-3l0oA:
undetectable		 1ovfB-3l0oA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		3 / 3 THR A 311
PRO A 145
THR A 144
 None
 0.87A 1unjR-3l0oA:
undetectable		 1unjR-3l0oA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		5 / 12 THR A 318
GLY A 175
GLY A 315
THR A 311
ILE A 319
 None
 1.35A 2akeA-3l0oA:
undetectable		 2akeA-3l0oA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		5 / 12 THR A 318
GLY A 175
GLY A 315
THR A 311
ILE A 319
 None
 1.34A 2azxA-3l0oA:
undetectable		 2azxA-3l0oA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		5 / 12 LEU A 249
ILE A 230
ILE A   8
ILE A 103
TYR A 128
 None
 1.24A 2efjA-3l0oA:
3.8		 2efjA-3l0oA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		4 / 7 ARG A  74
ILE A 108
PHE A  57
GLN A  49
 IUM  A 428 ( 4.2A)
None
None
None
 1.07A 2jc9A-3l0oA:
undetectable		 2jc9A-3l0oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		3 / 3 MET A 120
GLU A  23
ASN A  17
 None
 1.11A 3a27A-3l0oA:
undetectable		 3a27A-3l0oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		4 / 4 LEU A  46
MET A 120
ILE A 230
ASP A  77
 None
None
None
IUM  A 428 (-2.6A)
 1.31A 3hecA-3l0oA:
undetectable		 3hecA-3l0oA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		5 / 9 THR A 250
GLU A 252
LEU A 211
LEU A 268
ILE A 213
 None
 1.34A 3nbqA-3l0oA:
undetectable		 3nbqA-3l0oA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		3 / 3 ASN A 228
ALA A 200
ARG A 208
 None
 0.91A 3tj7C-3l0oA:
undetectable
3tj7D-3l0oA:
undetectable		 3tj7C-3l0oA:
20.42
3tj7D-3l0oA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		5 / 12 ARG A 208
ILE A 172
THR A 227
ALA A 308
ALA A 254
 None
 1.21A 3ua1A-3l0oA:
undetectable		 3ua1A-3l0oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		3 / 3 THR A 311
PRO A 145
THR A 144
 None
 0.87A 4hivD-3l0oA:
undetectable		 4hivD-3l0oA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		3 / 5 GLY A  70
GLY A  68
GLU A  67
 None
 0.41A 4z2eA-3l0oA:
undetectable
4z2eD-3l0oA:
undetectable		 4z2eA-3l0oA:
22.28
4z2eD-3l0oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		4 / 6 LYS A 300
PRO A 301
LEU A 251
GLU A 248
 None
 1.39A 4z4cA-3l0oA:
undetectable		 4z4cA-3l0oA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		5 / 12 PHE A  57
GLY A  58
GLY A 106
ILE A 104
LEU A 257
 None
 1.12A 5ul4A-3l0oA:
undetectable		 5ul4A-3l0oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		4 / 9 ILE A 207
ILE A 199
ILE A 195
LEU A 192
 None
 0.72A 5vkqB-3l0oA:
undetectable
5vkqC-3l0oA:
undetectable		 5vkqB-3l0oA:
13.53
5vkqC-3l0oA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		5 / 12 VAL A 264
ASP A 263
LEU A 251
ALA A 254
GLY A 314
 None
 1.08A 6b0iB-3l0oA:
2.7		 6b0iB-3l0oA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO
(Thermotoga
maritima) 		3 / 3 GLU A 372
LEU A 375
ARG A 151
 None
 0.71A 6d8fA-3l0oA:
undetectable		 6d8fA-3l0oA:
20.53