SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 244
LEU A 163
LEU A 160
ILE A 118
LEU A 209
 None
 1.48A 1a52A-3l0zA:
undetectable		 1a52A-3l0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 244
LEU A 163
LEU A 160
ILE A 118
LEU A 209
 None
 1.46A 1a52B-3l0zA:
undetectable		 1a52B-3l0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 263
LEU A  12
LYS A  16
SER A 293
ILE A 327
 None
 1.28A 1dreA-3l0zA:
undetectable		 1dreA-3l0zA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 244
LEU A 163
LEU A 160
ILE A 118
LEU A 209
 None
 1.48A 1ereA-3l0zA:
undetectable		 1ereA-3l0zA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 244
LEU A 163
LEU A 160
ILE A 118
LEU A 209
 None
 1.49A 1ereB-3l0zA:
undetectable		 1ereB-3l0zA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 244
LEU A 163
LEU A 160
ILE A 118
LEU A 209
 None
 1.48A 1ereC-3l0zA:
undetectable		 1ereC-3l0zA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 244
LEU A 163
LEU A 160
ILE A 118
LEU A 209
 None
 1.49A 1ereD-3l0zA:
undetectable		 1ereD-3l0zA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  48
ALA A  51
ASP A  52
GLU A  54
LEU A  55
 None
 0.49A 1errA-3l0zA:
undetectable		 1errA-3l0zA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 318
GLU A 315
GLY A 320
ILE A 235
LEU A 257
 None
 1.15A 1p91A-3l0zA:
undetectable		 1p91A-3l0zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 GLY A 239
GLN A 241
VAL A 174
SER A 243
 None
 1.38A 1zzqB-3l0zA:
undetectable		 1zzqB-3l0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  48
ALA A  51
GLU A  54
LEU A  55
PRO A  68
 None
 0.76A 2qxsA-3l0zA:
undetectable		 2qxsA-3l0zA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  48
ALA A  51
GLU A  54
LEU A  55
PRO A  68
 None
 0.77A 2qxsB-3l0zA:
undetectable		 2qxsB-3l0zA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 265
GLY A 238
SER A 243
VAL A 324
ILE A 235
 None
 1.05A 2wa2A-3l0zA:
undetectable		 2wa2A-3l0zA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A  78
GLY A 149
CYH A  24
HIS A  94
 None
 1.03A 2yldA-3l0zA:
undetectable		 2yldA-3l0zA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A  78
GLY A 149
CYH A  24
HIS A  94
 None
 1.07A 2ylgA-3l0zA:
undetectable		 2ylgA-3l0zA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 304
ILE A 302
PRO A  75
PRO A  68
THR A  76
 None
 1.35A 3bjwE-3l0zA:
undetectable		 3bjwE-3l0zA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 265
GLY A 320
GLY A 316
PHE A  11
ILE A 235
 None
 0.84A 3elwA-3l0zA:
undetectable		 3elwA-3l0zA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 263
LEU A  12
LYS A  16
SER A 293
ILE A 327
 None
 1.43A 3ia4A-3l0zA:
undetectable		 3ia4A-3l0zA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A  78
GLY A 149
CYH A  24
HIS A  94
 None
 1.03A 3zwiA-3l0zA:
undetectable		 3zwiA-3l0zA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CIP_A_ASCA130_0
(CYTOCHROME C')		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ALA A  78
GLY A 149
CYH A  24
HIS A  94
 None
 1.04A 4cipA-3l0zA:
0.0		 4cipA-3l0zA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 263
LEU A  12
LYS A  16
SER A 293
ILE A 327
 None
 1.20A 4gh8B-3l0zA:
undetectable		 4gh8B-3l0zA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  64
LYS A  65
THR A  66
 None
 0.55A 4lj0A-3l0zA:
undetectable		 4lj0A-3l0zA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A 328
ILE A  15
ILE A 235
ALA A 263
 None
 0.81A 4lv9A-3l0zA:
2.5		 4lv9A-3l0zA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		4 / 8 PRO A 153
SER A  38
VAL A 317
GLY A 316
 PO4  A 351 (-4.7A)
PO4  A 351 (-2.9A)
None
None
 0.98A 4mk4A-3l0zA:
2.4		 4mk4A-3l0zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 111
ASN A 125
SER A  28
 None
 0.87A 4obwA-3l0zA:
undetectable		 4obwA-3l0zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A 148
ILE A 249
ALA A 228
ILE A 252
 None
 0.81A 4uxqA-3l0zA:
undetectable		 4uxqA-3l0zA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  48
ALA A  51
ASP A  52
GLU A  54
LEU A  55
 None
 0.53A 4xi3A-3l0zA:
undetectable		 4xi3A-3l0zA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  48
ALA A  51
ASP A  52
LEU A  55
PRO A  68
 None
 0.83A 4xi3B-3l0zA:
undetectable		 4xi3B-3l0zA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 238
GLY A 239
THR A 240
ILE A 264
PHE A 295
 None
 1.23A 4zvmA-3l0zA:
2.2
4zvmB-3l0zA:
2.6		 4zvmA-3l0zA:
21.15
4zvmB-3l0zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 323
GLY A 265
GLY A 320
GLY A 318
LEU A 291
 None
 1.05A 5c0oH-3l0zA:
undetectable		 5c0oH-3l0zA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 246
ALA A 247
LEU A 163
GLY A 213
LEU A 209
 None
 1.32A 5dx3A-3l0zA:
undetectable		 5dx3A-3l0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A 246
ALA A 247
LEU A 163
MET A 216
GLY A 213
LEU A 209
 None
 1.44A 5gtrA-3l0zA:
undetectable		 5gtrA-3l0zA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 246
ALA A 247
LEU A 163
MET A 216
LEU A 209
 None
 1.44A 5hyrB-3l0zA:
undetectable		 5hyrB-3l0zA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A  78
GLY A 149
CYH A  24
HIS A  94
 None
 1.05A 5jliA-3l0zA:
undetectable		 5jliA-3l0zA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSL_A_ASCA202_0
(CYTOCHROME C')		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ALA A  78
GLY A 149
CYH A  24
HIS A  94
 None
 1.04A 5jslA-3l0zA:
0.0		 5jslA-3l0zA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A  78
GLY A 149
CYH A  24
HIS A  94
 None
 1.06A 5jt4A-3l0zA:
undetectable		 5jt4A-3l0zA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  39
GLY A 172
THR A 158
GLY A 155
GLY A 154
 PO4  A 351 (-4.4A)
None
None
PO4  A 351 (-4.2A)
PO4  A 351 (-3.0A)
 0.94A 5koxA-3l0zA:
undetectable		 5koxA-3l0zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 247
LEU A 163
MET A 216
GLY A 213
LEU A 209
 None
 1.28A 5wgqA-3l0zA:
undetectable		 5wgqA-3l0zA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		6 / 12 ILE A   6
PRO A 289
THR A 240
GLY A 239
THR A 266
GLY A 265
 None
 1.46A 6b6fA-3l0zA:
undetectable		 6b6fA-3l0zA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 265
GLY A 321
ILE A 264
ALA A 237
GLY A 239
 None
 1.04A 6e5zA-3l0zA:
3.9		 6e5zA-3l0zA:
21.88