SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		3 / 3 VAL A  19
VAL A  17
TRP A 311
 None
 0.92A 1av2A-3l12A:
undetectable
1av2B-3l12A:
undetectable		 1av2A-3l12A:
5.05
1av2B-3l12A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		3 / 3 TRP A 311
ALA A  42
VAL A  45
 None
 0.95A 1c4dA-3l12A:
undetectable
1c4dB-3l12A:
undetectable		 1c4dA-3l12A:
5.05
1c4dB-3l12A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		3 / 3 TRP A 311
ALA A  42
VAL A  45
 None
 0.88A 1c4dC-3l12A:
undetectable
1c4dD-3l12A:
undetectable		 1c4dC-3l12A:
5.05
1c4dD-3l12A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		4 / 7 THR A 274
GLY A  21
HIS A  22
THR A 300
 None
None
UNL  A 317 ( 3.8A)
None
 0.81A 1gtnF-3l12A:
undetectable
1gtnG-3l12A:
undetectable		 1gtnF-3l12A:
13.55
1gtnG-3l12A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		4 / 7 THR A 274
GLY A  21
HIS A  22
THR A 300
 None
None
UNL  A 317 ( 3.8A)
None
 0.91A 1gtnJ-3l12A:
undetectable
1gtnK-3l12A:
undetectable		 1gtnJ-3l12A:
13.55
1gtnK-3l12A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		3 / 3 ALA A  42
VAL A  45
TRP A 311
 None
 0.94A 1tkqB-3l12A:
undetectable		 1tkqB-3l12A:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		3 / 3 VAL A  19
VAL A  17
TRP A 311
 None
 0.96A 1w5uA-3l12A:
undetectable
1w5uB-3l12A:
undetectable		 1w5uA-3l12A:
5.05
1w5uB-3l12A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		4 / 6 TRP A 273
LEU A 247
LEU A 146
VAL A 293
 UNL  A 317 ( 4.1A)
None
None
None
 1.02A 2dqyC-3l12A:
undetectable		 2dqyC-3l12A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		5 / 12 GLY A  44
ALA A  43
GLY A  24
GLY A  21
ILE A  20
 None
 0.84A 2fxeA-3l12A:
undetectable		 2fxeA-3l12A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		3 / 3 VAL A  17
TRP A 311
VAL A  19
 None
 0.88A 2izqC-3l12A:
undetectable
2izqD-3l12A:
undetectable		 2izqC-3l12A:
5.05
2izqD-3l12A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		3 / 3 GLU A 148
HIS A  22
GLU A  49
 MG  A 313 (-2.9A)
UNL  A 317 ( 3.8A)
MG  A 313 (-2.6A)
 0.84A 2x45B-3l12A:
undetectable		 2x45B-3l12A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		3 / 3 GLU A 148
HIS A  22
GLU A  49
 MG  A 313 (-2.9A)
UNL  A 317 ( 3.8A)
MG  A 313 (-2.6A)
 0.85A 2x45C-3l12A:
undetectable		 2x45C-3l12A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		5 / 12 ASN A 276
ILE A 292
THR A 294
VAL A  17
ILE A 303
 None
 1.21A 3kpbA-3l12A:
undetectable		 3kpbA-3l12A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		5 / 12 ARG A  26
ASP A 295
GLU A  49
TRP A 273
GLU A  31
 CL  A 315 (-3.0A)
None
MG  A 313 (-2.6A)
UNL  A 317 ( 4.1A)
None
 1.40A 3lmyB-3l12A:
5.2		 3lmyB-3l12A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		4 / 7 ASP A  51
ASP A 295
ASN A  32
GLU A 148
 MG  A 313 (-2.6A)
None
None
MG  A 313 (-2.9A)
 1.23A 4fewB-3l12A:
undetectable		 4fewB-3l12A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		4 / 6 ASP A  51
ASP A 295
ASN A  32
GLU A 148
 MG  A 313 (-2.6A)
None
None
MG  A 313 (-2.9A)
 1.23A 4gkhJ-3l12A:
undetectable		 4gkhJ-3l12A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		5 / 12 GLY A  27
ASP A 295
HIS A  22
PHE A  37
GLN A 117
 None
None
UNL  A 317 ( 3.8A)
None
None
 1.37A 4wh5A-3l12A:
undetectable		 4wh5A-3l12A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		5 / 12 HIS A  66
VAL A  53
LEU A  68
VAL A 125
PRO A 126
 None
 1.08A 4xiwB-3l12A:
undetectable
4xiwE-3l12A:
undetectable		 4xiwB-3l12A:
20.95
4xiwE-3l12A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		4 / 6 ALA A 239
GLN A 238
LEU A 236
LEU A 268
 None
 1.18A 4xoyA-3l12A:
undetectable		 4xoyA-3l12A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		4 / 6 ALA A 239
GLN A 238
LEU A 236
LEU A 268
 None
 1.26A 4xp3A-3l12A:
undetectable		 4xp3A-3l12A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		5 / 11 LEU A 202
VAL A 183
PHE A  50
LEU A 128
LEU A 149
 None
 1.30A 4zbqA-3l12A:
undetectable		 4zbqA-3l12A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		5 / 12 GLY A 291
LEU A 309
ILE A 269
LEU A 247
GLY A   9
 None
None
None
None
CL  A 316 ( 4.2A)
 0.98A 5d4uC-3l12A:
undetectable		 5d4uC-3l12A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		5 / 7 VAL A 169
LEU A 128
ALA A 168
LEU A 149
LEU A 191
 None
 1.31A 5jq7A-3l12A:
undetectable		 5jq7A-3l12A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		4 / 8 HIS A  66
VAL A  53
LEU A  68
ALA A  69
 None
 0.95A 5tt3H-3l12A:
undetectable		 5tt3H-3l12A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		4 / 5 LEU A 207
LEU A 146
THR A 272
PRO A 297
 UNL  A 317 ( 4.5A)
None
None
None
 1.05A 6ew0F-3l12A:
undetectable		 6ew0F-3l12A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		4 / 6 LEU A 207
LEU A 146
THR A 272
PRO A 297
 UNL  A 317 ( 4.5A)
None
None
None
 1.05A 6ew0G-3l12A:
undetectable		 6ew0G-3l12A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Ruegeria
pomeroyi) 		4 / 6 LEU A 192
THR A 204
GLY A 245
ARG A 196
 None
 1.25A 6gtqB-3l12A:
undetectable
6gtqD-3l12A:
undetectable		 6gtqB-3l12A:
19.94
6gtqD-3l12A:
8.79