SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3l19'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		5 / 9 ILE A 466
LEU A 471
MET A 488
VAL A 500
MET A 508
 None
 0.70A 1ctrA-3l19A:
9.1		 1ctrA-3l19A:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		5 / 11 PHE A 458
ILE A 466
LEU A 471
MET A 488
MET A 508
 None
 0.79A 1dtlA-3l19A:
7.5		 1dtlA-3l19A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		3 / 3 TYR A 429
ASP A 423
ASP A 416
 None
CA  A   1 (-3.0A)
None
 0.77A 3ou7B-3l19A:
undetectable		 3ou7B-3l19A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		5 / 12 MET A 488
PHE A 475
ALA A 351
ALA A 353
ALA A 354
 None
 1.11A 4j6dA-3l19A:
undetectable		 4j6dA-3l19A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		5 / 12 MET A 488
PHE A 475
ALA A 351
ALA A 353
ALA A 354
 None
 1.12A 4j6dB-3l19A:
undetectable		 4j6dB-3l19A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		4 / 8 ILE A 466
LEU A 471
VAL A 500
MET A 508
 None
 0.51A 4rjdA-3l19A:
8.1		 4rjdA-3l19A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		5 / 8 PHE A 458
ILE A 466
LEU A 471
MET A 488
VAL A 500
 None
 0.80A 4rjdA-3l19A:
8.1		 4rjdA-3l19A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		5 / 9 ALA A 353
LEU A 480
LEU A 350
ASN A 346
LEU A 471
 None
 1.44A 4x30A-3l19A:
undetectable		 4x30A-3l19A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		4 / 6 TYR A 432
THR A 372
ARG A 376
ASP A 379
 GOL  A 521 ( 3.8A)
GOL  A 521 ( 4.1A)
GOL  A 521 (-3.0A)
CA  A   8 (-3.0A)
 0.78A 5mraA-3l19A:
undetectable
5mraB-3l19A:
undetectable		 5mraA-3l19A:
23.74
5mraB-3l19A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		4 / 6 TYR A 432
THR A 372
ASP A 379
GLY A 384
 GOL  A 521 ( 3.8A)
GOL  A 521 ( 4.1A)
CA  A   8 (-3.0A)
GOL  A 521 (-3.4A)
 0.72A 5mraA-3l19A:
undetectable
5mraB-3l19A:
undetectable		 5mraA-3l19A:
23.74
5mraB-3l19A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		4 / 7 LEU A 419
ASP A 423
ASP A 425
GLN A 385
 None
CA  A   1 (-3.0A)
CA  A   1 (-2.9A)
None
 1.35A 6g31D-3l19A:
undetectable		 6g31D-3l19A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS
(Cryptosporidium
parvum) 		4 / 6 LEU A 419
ASP A 423
ASP A 425
GLN A 385
 None
CA  A   1 (-3.0A)
CA  A   1 (-2.9A)
None
 1.25A 6g31J-3l19A:
undetectable		 6g31J-3l19A:
18.01